8,043 research outputs found
Bayesian orthogonal component analysis for sparse representation
This paper addresses the problem of identifying a lower dimensional space
where observed data can be sparsely represented. This under-complete dictionary
learning task can be formulated as a blind separation problem of sparse sources
linearly mixed with an unknown orthogonal mixing matrix. This issue is
formulated in a Bayesian framework. First, the unknown sparse sources are
modeled as Bernoulli-Gaussian processes. To promote sparsity, a weighted
mixture of an atom at zero and a Gaussian distribution is proposed as prior
distribution for the unobserved sources. A non-informative prior distribution
defined on an appropriate Stiefel manifold is elected for the mixing matrix.
The Bayesian inference on the unknown parameters is conducted using a Markov
chain Monte Carlo (MCMC) method. A partially collapsed Gibbs sampler is
designed to generate samples asymptotically distributed according to the joint
posterior distribution of the unknown model parameters and hyperparameters.
These samples are then used to approximate the joint maximum a posteriori
estimator of the sources and mixing matrix. Simulations conducted on synthetic
data are reported to illustrate the performance of the method for recovering
sparse representations. An application to sparse coding on under-complete
dictionary is finally investigated.Comment: Revised version. Accepted to IEEE Trans. Signal Processin
A blind deconvolution approach to recover effective connectivity brain networks from resting state fMRI data
A great improvement to the insight on brain function that we can get from
fMRI data can come from effective connectivity analysis, in which the flow of
information between even remote brain regions is inferred by the parameters of
a predictive dynamical model. As opposed to biologically inspired models, some
techniques as Granger causality (GC) are purely data-driven and rely on
statistical prediction and temporal precedence. While powerful and widely
applicable, this approach could suffer from two main limitations when applied
to BOLD fMRI data: confounding effect of hemodynamic response function (HRF)
and conditioning to a large number of variables in presence of short time
series. For task-related fMRI, neural population dynamics can be captured by
modeling signal dynamics with explicit exogenous inputs; for resting-state fMRI
on the other hand, the absence of explicit inputs makes this task more
difficult, unless relying on some specific prior physiological hypothesis. In
order to overcome these issues and to allow a more general approach, here we
present a simple and novel blind-deconvolution technique for BOLD-fMRI signal.
Coming to the second limitation, a fully multivariate conditioning with short
and noisy data leads to computational problems due to overfitting. Furthermore,
conceptual issues arise in presence of redundancy. We thus apply partial
conditioning to a limited subset of variables in the framework of information
theory, as recently proposed. Mixing these two improvements we compare the
differences between BOLD and deconvolved BOLD level effective networks and draw
some conclusions
Nonparametric volatility density estimation for discrete time models
We consider discrete time models for asset prices with a stationary
volatility process. We aim at estimating the multivariate density of this
process at a set of consecutive time instants. A Fourier type deconvolution
kernel density estimator based on the logarithm of the squared process is
proposed to estimate the volatility density. Expansions of the bias and bounds
on the variance are derived
Disentangling causal webs in the brain using functional Magnetic Resonance Imaging: A review of current approaches
In the past two decades, functional Magnetic Resonance Imaging has been used
to relate neuronal network activity to cognitive processing and behaviour.
Recently this approach has been augmented by algorithms that allow us to infer
causal links between component populations of neuronal networks. Multiple
inference procedures have been proposed to approach this research question but
so far, each method has limitations when it comes to establishing whole-brain
connectivity patterns. In this work, we discuss eight ways to infer causality
in fMRI research: Bayesian Nets, Dynamical Causal Modelling, Granger Causality,
Likelihood Ratios, LiNGAM, Patel's Tau, Structural Equation Modelling, and
Transfer Entropy. We finish with formulating some recommendations for the
future directions in this area
Towards many colors in FISH on 3D-preserved interphase nuclei
The article reviews the existing methods of multicolor FISH on nuclear targets, first of all, interphase chromosomes. FISH proper and image acquisition are considered as two related components of a single process. We discuss (1) M-FISH (combinatorial labeling + deconvolution + widefield microscopy); (2) multicolor labeling + SIM (structured illumination microscopy); (3) the standard approach to multicolor FISH + CLSM (confocal laser scanning microscopy; one fluorochrome - one color channel); (4) combinatorial labeling + CLSM; (5) non-combinatorial labeling + CLSM + linear unmixing. Two related issues, deconvolution of images acquired with CLSM and correction of data for chromatic Z-shift, are also discussed. All methods are illustrated with practical examples. Finally, several rules of thumb helping to choose an optimal labeling + microscopy combination for the planned experiment are suggested. Copyright (c) 2006 S. Karger AG, Basel
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