Decoding Hand Kinematics from Local Field Potentials Using Long Short-Term Memory (LSTM) Network

Local field potential (LFP) has gained increasing interest as an alternative input signal for brain-machine interfaces (BMIs) due to its informative features, long-term stability, and low frequency content. However, despite these interesting properties, LFP-based BMIs have been reported to yield low decoding performances compared to spike-based BMIs. In this paper, we propose a new decoder based on long short-term memory (LSTM) network which aims to improve the decoding performance of LFP-based BMIs. We compare offline decoding performance of the proposed LSTM decoder to a commonly used Kalman filter (KF) decoder on hand kinematics prediction tasks from multichannel LFPs. We also benchmark the performance of LFP-driven LSTM decoder against KF decoder driven by two types of spike signals: single-unit activity (SUA) and multi-unit activity (MUA). Our results show that LFP-driven LSTM decoder achieves significantly better decoding performance than LFP-, SUA-, and MUA-driven KF decoders. This suggests that LFPs coupled with LSTM decoder could provide high decoding performance, robust, and low power BMIs

Improved spike-based brain-machine interface using bayesian adaptive kernel smoother and deep learning

Multiunit activity (MUA) has been proposed to mitigate the robustness issue faced by single-unit activity (SUA)-based brain-machine interfaces (BMIs). Most MUA-based BMIs still employ a binning method for estimating firing rates and linear decoder for decoding behavioural parameters. The limitations of binning and linear decoder lead to suboptimal performance of MUA-based BMIs. To address this issue, we propose a method which consists of Bayesian adaptive kernel smoother (BAKS) as the firing rate estimation algorithm and deep learning, particularly quasi-recurrent neural network (QRNN), as the decoding algorithm. We evaluated the proposed method for reconstructing (offline) hand kinematics from intracortical neural data chronically recorded from the primary motor cortex of two non-human primates. Extensive empirical results across recording sessions and subjects showed that the proposed method consistently outperforms other combinations of firing rate estimation algorithm and decoding algorithm. Overall results suggest the effectiveness of the proposed method for improving the decoding performance of MUA-based BMIs

Cortical encoding and decoding models of speech production

To speak is to dynamically orchestrate the movements of the articulators (jaw, tongue, lips, and larynx), which in turn generate speech sounds. It is an amazing mental and motor feat that is controlled by the brain and is fundamental for communication. Technology that could translate brain signals into speech would be transformative for people who are unable to communicate as a result of neurological impairments. This work first investigates how articulator movements that underlie natural speech production are represented in the brain. Building upon this, this work also presents a neural decoder that can synthesize audible speech from brain signals. Data to support these results were from direct cortical recordings of the human sensorimotor cortex while participants spoke natural sentences. Neural activity at individual electrodes encoded a diversity of articulatory kinematic trajectories (AKTs), each revealing coordinated articulator movements towards specific vocal tract shapes. The neural decoder was designed to leverage the kinematic trajectories encoded in the sensorimotor cortex which enhanced performance even with limited data. In closed vocabulary tests, listeners could readily identify and transcribe speech synthesized from cortical activity. These findings advance the clinical viability of using speech neuroprosthetic technology to restore spoken communication

Decoding Kinematic Information From Primary Motor Cortex Ensemble Activities Using a Deep Canonical Correlation Analysis

The control of arm movements through intracortical brain-machine interfaces (BMIs) mainly relies on the activities of the primary motor cortex (M1) neurons and mathematical models that decode their activities. Recent research on decoding process attempts to not only improve the performance but also simultaneously understand neural and behavioral relationships. In this study, we propose an efficient decoding algorithm using a deep canonical correlation analysis (DCCA), which maximizes correlations between canonical variables with the non-linear approximation of mappings from neuronal to canonical variables via deep learning. We investigate the effectiveness of using DCCA for finding a relationship between M1 activities and kinematic information when non-human primates performed a reaching task with one arm. Then, we examine whether using neural activity representations from DCCA improves the decoding performance through linear and non-linear decoders: a linear Kalman filter (LKF) and a long short-term memory in recurrent neural networks (LSTM-RNN). We found that neural representations of M1 activities estimated by DCCA resulted in more accurate decoding of velocity than those estimated by linear canonical correlation analysis, principal component analysis, factor analysis, and linear dynamical system. Decoding with DCCA yielded better performance than decoding the original FRs using LSTM-RNN (6.6 and 16.0% improvement on average for each velocity and position, respectively; Wilcoxon rank sum test, p < 0.05). Thus, DCCA can identify the kinematics-related canonical variables of M1 activities, thus improving the decoding performance. Our results may help advance the design of decoding models for intracortical BMIs

Data-Driven Approaches For Decoding Volitional Movement Intent From Bioelectrical Signals

There are nearly two million limb amputees living in the United States of America. Loss of limbs results in profound changes in one's life. However, the underlying neural circuitry and much of the ability to sense and control movements of their missing limb is retained even after limb loss. This means that amputee has the ability to control artificial limbs in a manner similar to how the limb was controlled before the loss. The goal of this research is to develop technologies for creating prosthetics arms that behave like the natural limb. Movement intent decoders allow amputees to control prostheses by interpreting motor-related bioelectrical signals, restoring their ability to perform day-to-day tasks. Such systems have to overcome a number of challenges before they can become practical. These challenges include the recursive nature of the human decision-making process, the limited amount of data typically available for training and the time-varying proper! ties of the nervous system. In this dissertation, we apply data-driven techniques to develop precise movement intent decoders and prosthetic controllers. Specifically, this work makes three major contributions to the field: 1- We developed movement intent decoders based on different neural network architectures including multilayer perceptron networks, convolutional neural networks, and long short-term memory neural networks. These systems were trained with a dataset aggregation (DAgger) approach, an imitation learning algorithm. DAgger augments the training set based on the decoder outputs in the training stage, mitigating possible mistakes that the decoders could make. The decoders were validated in offline analyses using data from two amputee arm subjects. The results demonstrated an improvement of up to 60% in the normalized mean-square decoding error over state-of-the-art decoders. 2- Movement intent decoders can be of different types, including proportional controllers, classification-based decoders or goal-based estimators. Each of these types of decoders come with their own set of advantages and weaknesses. We developed a shared-controller framework able to combine multiple decoders to control a prosthetic limb taking advantage of the individual strengths of the component decoders. The shared-controller framework was validated using two shared controller-systems. The first one combined a Kalman Filter (KF)-based decoder and a classifier-based decoder. The second system consisted of a KF-based decoder and a controller with knowledge of the final goal with a substantial amount of uncertainty. The controllers were validated using three amputees and three intact-arm subjects. The shared-controller systems outperformed the component decoders in most of the used metrics. An example of this is the subjects were able to stay in the intended position 70% longer using the KF-based decoder combined with a classifier-based decoder when compared with the KF-based decoder alone and 283% longer when compared with the classifier-based decoder alone. 3- Although the human body is a time-varying system, the decoders parameters are kept unchanged after training in many prosthesis systems. This causes a performance deterioration for the decoders over time. We developed an online-learning algorithm that is able to adapt itself during the post-training phase. The performance of such decoders were validated using data from two amputee subjects with transradial amputation. After 5 months of the initial training, the decoder with adaptation exhibited a 27% lower normalized mean-squared decoding error when compared with the same decoder without adaptation. In summary, the contributions of this research resulted in better training algorithms creating more accurate volitional movement intent decoders than previously possible, shared prosthesis controllers that combine multiple decoders in ways that perform better than the component decoders, and an online learning algorithm that enables the decoders to perform significantly better in the long term than current decoder realizations. Together, these contributions have brought us closer to the goal of creating limb prostheses that work and feel like the real limb

On the Utility of Representation Learning Algorithms for Myoelectric Interfacing

Electrical activity produced by muscles during voluntary movement is a reflection of the firing patterns of relevant motor neurons and, by extension, the latent motor intent driving the movement. Once transduced via electromyography (EMG) and converted into digital form, this activity can be processed to provide an estimate of the original motor intent and is as such a feasible basis for non-invasive efferent neural interfacing. EMG-based motor intent decoding has so far received the most attention in the field of upper-limb prosthetics, where alternative means of interfacing are scarce and the utility of better control apparent. Whereas myoelectric prostheses have been available since the 1960s, available EMG control interfaces still lag behind the mechanical capabilities of the artificial limbs they are intended to steer—a gap at least partially due to limitations in current methods for translating EMG into appropriate motion commands. As the relationship between EMG signals and concurrent effector kinematics is highly non-linear and apparently stochastic, finding ways to accurately extract and combine relevant information from across electrode sites is still an active area of inquiry.This dissertation comprises an introduction and eight papers that explore issues afflicting the status quo of myoelectric decoding and possible solutions, all related through their use of learning algorithms and deep Artificial Neural Network (ANN) models. Paper I presents a Convolutional Neural Network (CNN) for multi-label movement decoding of high-density surface EMG (HD-sEMG) signals. Inspired by the successful use of CNNs in Paper I and the work of others, Paper II presents a method for automatic design of CNN architectures for use in myocontrol. Paper III introduces an ANN architecture with an appertaining training framework from which simultaneous and proportional control emerges. Paper Iv introduce a dataset of HD-sEMG signals for use with learning algorithms. Paper v applies a Recurrent Neural Network (RNN) model to decode finger forces from intramuscular EMG. Paper vI introduces a Transformer model for myoelectric interfacing that do not need additional training data to function with previously unseen users. Paper vII compares the performance of a Long Short-Term Memory (LSTM) network to that of classical pattern recognition algorithms. Lastly, paper vIII describes a framework for synthesizing EMG from multi-articulate gestures intended to reduce training burden

Characterization of Language Cortex Activity During Speech Production and Perception

Millions of people around the world suffer from severe neuromuscular disorders such as spinal cord injury, cerebral palsy, amyotrophic lateral sclerosis (ALS), and others. Many of these individuals cannot perform daily tasks without assistance and depend on caregivers, which adversely impacts their quality of life. A Brain-Computer Interface (BCI) is technology that aims to give these people the ability to interact with their environment and communicate with the outside world. Many recent studies have attempted to decode spoken and imagined speech directly from brain signals toward the development of a natural-speech BCI. However, the current progress has not reached practical application. An approach to improve the performance of this technology is to better understand the underlying speech processes in the brain for further optimization of existing models. In order to extend research in this direction, this thesis aims to characterize and decode the auditory and articulatory features from the motor cortex using the electrocorticogram (ECoG). Consonants were chosen as auditory representations, and both places of articulation and manners of articulation were chosen as articulatory representations. The auditory and articulatory representations were decoded at different time lags with respect to the speech onset to determine optimal temporal decoding parameters. In addition, this work explores the role of the temporal lobe during speech production directly from ECoG signals. A novel decoding model using temporal lobe activity was developed to predict a spectral representation of the speech envelope during speech production. This new knowledge may be used to enhance existing speech-based BCI systems, which will offer a more natural communication modality. In addition, the work contributes to the field of speech neurophysiology by providing a better understanding of speech processes in the brain

Articulated motion and deformable objects

This guest editorial introduces the twenty two papers accepted for this Special Issue on Articulated Motion and Deformable Objects (AMDO). They are grouped into four main categories within the field of AMDO: human motion analysis (action/gesture), human pose estimation, deformable shape segmentation, and face analysis. For each of the four topics, a survey of the recent developments in the field is presented. The accepted papers are briefly introduced in the context of this survey. They contribute novel methods, algorithms with improved performance as measured on benchmarking datasets, as well as two new datasets for hand action detection and human posture analysis. The special issue should be of high relevance to the reader interested in AMDO recognition and promote future research directions in the field