Overview of the ImageCLEF 2013 medical tasks

In 2013, the tenth edition of the medical task of the Image-CLEF benchmark was organized. For the first time, the ImageCLEFmedworkshop takes place in the United States of America at the annualAMIA (American Medical Informatics Association) meeting even thoughthe task was organized as in previous years in connection with the otherImageCLEF tasks. Like 2012, a subset of the open access collection ofPubMed Central was distributed. This year, there were four subtasks:modality classification, compound figure separation, image–based andcase–based retrieval. The compound figure separation task was includeddue to the large number of multipanel images available in the literatureand the importance to separate them for targeted retrieval. More com-pound figures were also included in the modality classification task tomake it correspond to the distribution in the full database. The retrievaltasks remained in the same format as in previous years but a largernumber of tasks were available for image–based and case–based tasks.This paper presents an analysis of the techniques applied by the tengroups participating 2013 in ImageCLEFmed

ShARe/CLEF eHealth evaluation lab 2014, task 3: user-centred health information retrieval

This paper presents the results of task 3 of the ShARe/CLEF eHealth Evaluation Lab 2014. This evaluation lab focuses on improving access to medical information on the web. The task objective was to investigate the effect of using additional information such as a related discharge summary and external resources such as medical ontologies on the IR effectiveness, in a monolingual and in a multilingual context. The participants were allowed to submit up to seven runs for each language, one mandatory run using no additional information or external resources, and three each using or not using discharge summaries

Medical Image Retrieval Using Multimodal Semantic Indexing

Large collections of medical images have become a valuable source of knowledge, taking an important role in education, medical research and clinical decision making. An important unsolved issue that is actively investigated is the efficient and effective access to these repositories. This work addresses the problem of information retrieval in large collections of biomedical images, allowing to use sample images as alternative queries to the classic keywords. The proposed approach takes advantage of both modalities: text and visual information. The main drawback of the multimodal strategies is that the associated algorithms are memory and computation intensive. So, an important challenge addressed in this work is the design of scalable strategies, that can be applied efficiently and effectively in large medical image collections. The experimental evaluation shows that the proposed multimodal strategies are useful to improve the image retrieval performance, and are fully applicable to large image repositories.Maestrí

Data-driven Representation Learning from Histopathology Image Databases to Support Digital Pathology Analysis

Cancer research is a major public health priority in the world due to its high incidence, diversity and mortality. Despite great advances in this area during recent decades, the high incidence and lack of specialists have proven that one of the major challenges is to achieve early diagnosis. Improved early diagnosis, especially in developing countries, plays a crucial role in timely treatment and patient survival. Recent advances in scanner technology for the digitization of pathology slides and the growth of global initiatives to build databases for cancer research have enabled the emergence of digital pathology as a new approach to support pathology workflows. This has led to the development of many computational methods for automatic histopathology image analysis, which in turn has raised new computational challenges due to the high visual variability of histopathology slides, the difficulty in assessing the effectiveness of methods (considering the lack of annotated data from different pathologists and institutions), and the need of interpretable, efficient and feasible methods for practical use. On the other hand, machine learning techniques have focused on exploiting large databases to automatically extract and induce information and knowledge, in the form of patterns and rules, that allow to connect low-level content with its high-level meaning. Several approaches have emerged as opposed to traditional schemes based on handcrafted features for data representation, which nowadays are known as representation learning. The objective of this thesis is the exploration, development and validation of precise, interpretable and efficient computational machine learning methods for automatic representation learning from histopathology image databases to support diagnosis tasks of different types of cancer. The validation of the proposed methods during the thesis development allowed to corroborate their capability in several histopathology image analysis tasks of different types of cancer. These methods achieve good results in terms of accuracy, robustness, reproducibility, interpretability and feasibility suggesting their potential practical application towards translational and personalized medicine.Resumen. La investigación en cáncer es una de las principales prioridades de salud pública en el mundo debido a su alta incidencia, diversidad y mortalidad. A pesar de los grandes avances en el área en las últimas décadas, la alta incidencia y la falta de especialistas ha llevado a que una de las principales problemáticas sea lograr su detección temprana, en especial en países en vías de desarrollo, como quiera a que de ello depende las posibilidades de un tratamiento oportuno y las oportunidades de supervivencia de los pacientes. Los recientes avances en tecnología de escáneres para digitalización de láminas de patología y el crecimiento de iniciativas mundiales para la construcción de bases de datos para la investigación en cáncer, han permitido el surgimiento de la patología digital como un nuevo enfoque para soportar los flujos de trabajo en patología. Esto ha llevado al desarrollo de una gran variedad de métodos computacionales para el análisis automático de imágenes de histopatología, lo cual ha planteado nuevos desafíos computacionales debido a la alta variabilidad visual de las láminas de histopatología; la dificultad para evaluar la efectividad de los métodos por la falta de datos de diferentes instituciones que cuenten con anotaciones por parte de los patólogos, y la necesidad de métodos interpretables, eficientes y factibles para su uso práctico. Por otro lado, el aprendizaje de máquina se ha enfocado en explotar las grandes bases de datos para extraer e inducir de manera automática información y conocimiento, en forma de patrones y reglas, que permita conectar el contenido de bajo nivel con su significado. Diferentes técnicas han surgido en contraposición a los esquemas tradicionales basados en diseño manual de la representación de los datos, en lo que se conoce como aprendizaje de la representación. El propósito de esta tesis fue la exploración, desarrollo y validación de métodos computacionales de aprendizaje de máquina precisos, interpretables y eficientes a partir de bases de datos de imágenes de histopatología para el aprendizaje automático de la representación en tareas de apoyo al diagnóstico de distintos tipos de cáncer. La validación de los distintos métodos propuestos durante el desarrollo de la tesis permitieron corroborar la capacidad de cada uno de ellos en distintivas tareas de análisis de imágenes de histopatología, en diferentes tipos de cáncer, con buenos resultados en términos de exactitud, robustez, reproducibilidad, interpretabilidad y factibilidad, lo cual sugiere su potencial aplicación práctica hacia la medicina traslacional y personalizada.Doctorad

DEMIR at ImageCLEFMed 2012: Inter-modality and intra-modality integrated combination retrieval

This paper present the details of participation of DEMIR (Dokuz Eylul University Multimedia Information Retrieval) research team to the ImageCLEF 2012 Medical Retrieval task. This year, we evaluated impact of our proposed Integrated Combination method and Explicit Graded relevance feedback on the most descriptive low level features of images and best text retrieval result. We improved results by examination of different level of integrated approach for retrieved text data and low level features. We tested multi-modality image retrieval in ImageCLEF 2012 medical retrieval task and obtained the best rank in visual retrieval due to our experiments. The results clearly show that proper combination of different modalities improve the overall retrieval performance