Visual Quality Enhancement in Optoacoustic Tomography using Active Contour Segmentation Priors

Segmentation of biomedical images is essential for studying and characterizing anatomical structures, detection and evaluation of pathological tissues. Segmentation has been further shown to enhance the reconstruction performance in many tomographic imaging modalities by accounting for heterogeneities of the excitation field and tissue properties in the imaged region. This is particularly relevant in optoacoustic tomography, where discontinuities in the optical and acoustic tissue properties, if not properly accounted for, may result in deterioration of the imaging performance. Efficient segmentation of optoacoustic images is often hampered by the relatively low intrinsic contrast of large anatomical structures, which is further impaired by the limited angular coverage of some commonly employed tomographic imaging configurations. Herein, we analyze the performance of active contour models for boundary segmentation in cross-sectional optoacoustic tomography. The segmented mask is employed to construct a two compartment model for the acoustic and optical parameters of the imaged tissues, which is subsequently used to improve accuracy of the image reconstruction routines. The performance of the suggested segmentation and modeling approach are showcased in tissue-mimicking phantoms and small animal imaging experiments.Comment: Accepted for publication in IEEE Transactions on Medical Imagin

Optimization of Nanoparticle-Based SERS Substrates through Large-Scale Realistic Simulations

Surface-enhanced Raman scattering (SERS) has become a widely used spectroscopic technique for chemical identification, providing unbeaten sensitivity down to the singlemolecule level. The amplification of the optical near field produced by collective electron excitations plasmons in nanostructured metal surfaces gives rise to a dramatic increase by many orders of magnitude in the Raman scattering intensities from neighboring molecules. This effect strongly depends on the detailed geometry and composition of the plasmonsupporting metallic structures. However, the search for optimized SERS substrates has largely relied on empirical data, due in part to the complexity of the structures, whose simulation becomes prohibitively demanding. In this work, we use state-of-the-art electromagnetic computation techniques to produce predictive simulations for a wide range of nanoparticle-based SERS substrates, including realistic configurations consisting of random arrangements of hundreds of nanoparticles with various morphologies. This allows us to derive rules of thumb for the influence of particle anisotropy and substrate coverage on the obtained SERS enhancement and optimum spectral ranges of operation. Our results provide a solid background to understand and design optimized SERS substrates.Peer ReviewedPostprint (published version

Context-Patch Face Hallucination Based on Thresholding Locality-Constrained Representation and Reproducing Learning

Face hallucination is a technique that reconstruct high-resolution (HR) faces from low-resolution (LR) faces, by using the prior knowledge learned from HR/LR face pairs. Most state-of-the-arts leverage position-patch prior knowledge of human face to estimate the optimal representation coefficients for each image patch. However, they focus only the position information and usually ignore the context information of image patch. In addition, when they are confronted with misalignment or the Small Sample Size (SSS) problem, the hallucination performance is very poor. To this end, this study incorporates the contextual information of image patch and proposes a powerful and efficient context-patch based face hallucination approach, namely Thresholding Locality-constrained Representation and Reproducing learning (TLcR-RL). Under the context-patch based framework, we advance a thresholding based representation method to enhance the reconstruction accuracy and reduce the computational complexity. To further improve the performance of the proposed algorithm, we propose a promotion strategy called reproducing learning. By adding the estimated HR face to the training set, which can simulates the case that the HR version of the input LR face is present in the training set, thus iteratively enhancing the final hallucination result. Experiments demonstrate that the proposed TLcR-RL method achieves a substantial increase in the hallucinated results, both subjectively and objectively. Additionally, the proposed framework is more robust to face misalignment and the SSS problem, and its hallucinated HR face is still very good when the LR test face is from the real-world. The MATLAB source code is available at https://github.com/junjun-jiang/TLcR-RL

Detail Preserving Low Illumination Image and Video Enhancement Algorithm Based on Dark Channel Prior

In low illumination situations, insufficient light in the monitoring device results in poor visibility of effective information, which cannot meet practical applications. To overcome the above problems, a detail preserving low illumination video image enhancement algorithm based on dark channel prior is proposed in this paper. First, a dark channel refinement method is proposed, which is defined by imposing a structure prior to the initial dark channel to improve the image brightness. Second, an anisotropic guided filter (AnisGF) is used to refine the transmission, which preserves the edges of the image. Finally, a detail enhancement algorithm is proposed to avoid the problem of insufficient detail in the initial enhancement image. To avoid video flicker, the next video frames are enhanced based on the brightness of the first enhanced frame. Qualitative and quantitative analysis shows that the proposed algorithm is superior to the contrast algorithm, in which the proposed algorithm ranks first in average gradient, edge intensity, contrast, and patch-based contrast quality index. It can be effectively applied to the enhancement of surveillance video images and for wider computer vision applications