3,668 research outputs found
Reachability in Biochemical Dynamical Systems by Quantitative Discrete Approximation (extended abstract)
In this paper, a novel computational technique for finite discrete
approximation of continuous dynamical systems suitable for a significant class
of biochemical dynamical systems is introduced. The method is parameterized in
order to affect the imposed level of approximation provided that with
increasing parameter value the approximation converges to the original
continuous system. By employing this approximation technique, we present
algorithms solving the reachability problem for biochemical dynamical systems.
The presented method and algorithms are evaluated on several exemplary
biological models and on a real case study.Comment: In Proceedings CompMod 2011, arXiv:1109.104
Algorithmic Verification of Continuous and Hybrid Systems
We provide a tutorial introduction to reachability computation, a class of
computational techniques that exports verification technology toward continuous
and hybrid systems. For open under-determined systems, this technique can
sometimes replace an infinite number of simulations.Comment: In Proceedings INFINITY 2013, arXiv:1402.661
Sapo: Reachability Computation and Parameter Synthesis of Polynomial Dynamical Systems
Sapo is a C++ tool for the formal analysis of polynomial dynamical systems.
Its main features are: 1) Reachability computation, i.e., the calculation of
the set of states reachable from a set of initial conditions, and 2) Parameter
synthesis, i.e., the refinement of a set of parameters so that the system
satisfies a given specification. Sapo can represent reachable sets as unions of
boxes, parallelotopes, or parallelotope bundles (symbolic representation of
polytopes). Sets of parameters are represented with polytopes while
specifications are formalized as Signal Temporal Logic (STL) formulas
Analysis of parametric biological models with non-linear dynamics
In this paper we present recent results on parametric analysis of biological
models. The underlying method is based on the algorithms for computing
trajectory sets of hybrid systems with polynomial dynamics. The method is then
applied to two case studies of biological systems: one is a cardiac cell model
for studying the conditions for cardiac abnormalities, and the second is a
model of insect nest-site choice.Comment: In Proceedings HSB 2012, arXiv:1208.315
Control of complex networks requires both structure and dynamics
The study of network structure has uncovered signatures of the organization
of complex systems. However, there is also a need to understand how to control
them; for example, identifying strategies to revert a diseased cell to a
healthy state, or a mature cell to a pluripotent state. Two recent
methodologies suggest that the controllability of complex systems can be
predicted solely from the graph of interactions between variables, without
considering their dynamics: structural controllability and minimum dominating
sets. We demonstrate that such structure-only methods fail to characterize
controllability when dynamics are introduced. We study Boolean network
ensembles of network motifs as well as three models of biochemical regulation:
the segment polarity network in Drosophila melanogaster, the cell cycle of
budding yeast Saccharomyces cerevisiae, and the floral organ arrangement in
Arabidopsis thaliana. We demonstrate that structure-only methods both
undershoot and overshoot the number and which sets of critical variables best
control the dynamics of these models, highlighting the importance of the actual
system dynamics in determining control. Our analysis further shows that the
logic of automata transition functions, namely how canalizing they are, plays
an important role in the extent to which structure predicts dynamics.Comment: 15 pages, 6 figure
Model Checking Tap Withdrawal in C. Elegans
We present what we believe to be the first formal verification of a
biologically realistic (nonlinear ODE) model of a neural circuit in a
multicellular organism: Tap Withdrawal (TW) in \emph{C. Elegans}, the common
roundworm. TW is a reflexive behavior exhibited by \emph{C. Elegans} in
response to vibrating the surface on which it is moving; the neural circuit
underlying this response is the subject of this investigation. Specifically, we
perform reachability analysis on the TW circuit model of Wicks et al. (1996),
which enables us to estimate key circuit parameters. Underlying our approach is
the use of Fan and Mitra's recently developed technique for automatically
computing local discrepancy (convergence and divergence rates) of general
nonlinear systems. We show that the results we obtain are in agreement with the
experimental results of Wicks et al. (1995). As opposed to the fixed parameters
found in most biological models, which can only produce the predominant
behavior, our techniques characterize ranges of parameters that produce (and do
not produce) all three observed behaviors: reversal of movement, acceleration,
and lack of response
A Survey of Cellular Automata: Types, Dynamics, Non-uniformity and Applications
Cellular automata (CAs) are dynamical systems which exhibit complex global
behavior from simple local interaction and computation. Since the inception of
cellular automaton (CA) by von Neumann in 1950s, it has attracted the attention
of several researchers over various backgrounds and fields for modelling
different physical, natural as well as real-life phenomena. Classically, CAs
are uniform. However, non-uniformity has also been introduced in update
pattern, lattice structure, neighborhood dependency and local rule. In this
survey, we tour to the various types of CAs introduced till date, the different
characterization tools, the global behaviors of CAs, like universality,
reversibility, dynamics etc. Special attention is given to non-uniformity in
CAs and especially to non-uniform elementary CAs, which have been very useful
in solving several real-life problems.Comment: 43 pages; Under review in Natural Computin
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