Finding Maximal 2-Dimensional Palindromes

This paper extends the problem of palindrome searching into a higher dimension, addressing two definitions of 2D palindromes. The first definition implies a square, while the second definition (also known as a centrosymmetric factor), can be any rectangular shape. We describe two algorithms for searching a 2D text for maximal palindromes, one for each type of 2D palindrome. The first algorithm is optimal; it runs in linear time, on par with Manacher\u27s linear time 1D palindrome algorithm. The second algorithm searches a text of size n_1 x n_2 (n_1 >= n_2) in O(n_2) time for each of its n_1 x n_2 positions. Since each position may have up to O(n_2) maximal palindromes centered at that location, the second result is also optimal in terms of the worst-case output size

Longest substring palindrome after edit

It is known that the length of the longest substring palindromes (LSPals) of a given string T of length n can be computed in O(n) time by Manacher\u27s algorithm [J. ACM \u2775]. In this paper, we consider the problem of finding the LSPal after the string is edited. We present an algorithm that uses O(n) time and space for preprocessing, and answers the length of the LSPals in O(log (min {sigma, log n })) time after single character substitution, insertion, or deletion, where sigma denotes the number of distinct characters appearing in T. We also propose an algorithm that uses O(n) time and space for preprocessing, and answers the length of the LSPals in O(l + log n) time, after an existing substring in T is replaced by a string of arbitrary length l

Small-Space LCE Data Structure with Constant-Time Queries

The longest common extension (LCE) problem is to preprocess a given string w of length n so that the length of the longest common prefix between suffixes of w that start at any two given positions is answered quickly. In this paper, we present a data structure of O(z tau^2 + frac{n}{tau}) words of space which answers LCE queries in O(1) time and can be built in O(n log sigma) time, where 1 leq tau leq sqrt{n} is a parameter, z is the size of the Lempel-Ziv 77 factorization of w and sigma is the alphabet size. The proposed LCE data structure not access the input string w when answering queries, and thus w can be deleted after preprocessing. On top of this main result, we obtain further results using (variants of) our LCE data structure, which include the following: - For highly repetitive strings where the ztau^2 term is dominated by frac{n}{tau}, we obtain a constant-time and sub-linear space LCE query data structure. - Even when the input string is not well compressible via Lempel-Ziv 77 factorization, we still can obtain a constant-time and sub-linear space LCE data structure for suitable tau and for sigma leq 2^{o(log n)}. - The time-space trade-off lower bounds for the LCE problem by Bille et al. [J. Discrete Algorithms, 25:42-50, 2014] and by Kosolobov [CoRR, abs/1611.02891, 2016] do not apply in some cases with our LCE data structure

Patterns and Signals of Biology: An Emphasis On The Role of Post Translational Modifications in Proteomes for Function and Evolutionary Progression

After synthesis, a protein is still immature until it has been customized for a specific task. Post-translational modifications (PTMs) are steps in biosynthesis to perform this customization of protein for unique functionalities. PTMs are also important to protein survival because they rapidly enable protein adaptation to environmental stress factors by conformation change. The overarching contribution of this thesis is the construction of a computational profiling framework for the study of biological signals stemming from PTMs associated with stressed proteins. In particular, this work has been developed to predict and detect the biological mechanisms involved in types of stress response with PTMs in mitochondrial (Mt) and non-Mt protein. Before any mechanism can be studied, there must first be some evidence of its existence. This evidence takes the form of signals such as biases of biological actors and types of protein interaction. Our framework has been developed to locate these signals, distilled from “Big Data” resources such as public databases and the the entire PubMed literature corpus. We apply this framework to study the signals to learn about protein stress responses involving PTMs, modification sites (MSs). We developed of this framework, and its approach to analysis, according to three main facets: (1) by statistical evaluation to determine patterns of signal dominance throughout large volumes of data, (2) by signal location to track down the regions where the mechanisms must be found according to the types and numbers of associated actors at relevant regions in protein, and (3) by text mining to determine how these signals have been previously investigated by researchers. The results gained from our framework enable us to uncover the PTM actors, MSs and protein domains which are the major components of particular stress response mechanisms and may play roles in protein malfunction and disease