Data-driven modelling of biological multi-scale processes

Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales. In this manuscript we review mathematical modelling approaches used to describe the individual spatial scales and how they are integrated into holistic models. We discuss the relation between spatial and temporal scales and the implication of that on multi-scale modelling. Based upon this overview over state-of-the-art modelling approaches, we formulate key challenges in mathematical and computational modelling of biological multi-scale and multi-physics processes. In particular, we considered the availability of analysis tools for multi-scale models and model-based multi-scale data integration. We provide a compact review of methods for model-based data integration and model-based hypothesis testing. Furthermore, novel approaches and recent trends are discussed, including computation time reduction using reduced order and surrogate models, which contribute to the solution of inference problems. We conclude the manuscript by providing a few ideas for the development of tailored multi-scale inference methods.Comment: This manuscript will appear in the Journal of Coupled Systems and Multiscale Dynamics (American Scientific Publishers

Control Theory: A Mathematical Perspective on Cyber-Physical Systems

Control theory is an interdisciplinary field that is located at the crossroads of pure and applied mathematics with systems engineering and the sciences. Recently the control field is facing new challenges motivated by application domains that involve networks of systems. Examples are interacting robots, networks of autonomous cars or the smart grid. In order to address the new challenges posed by these application disciplines, the special focus of this workshop has been on the currently very active field of Cyber-Physical Systems, which forms the underlying basis for many network control applications. A series of lectures in this workshop was devoted to give an overview on current theoretical developments in Cyber-Physical Systems, emphasizing in particular the mathematical aspects of the field. Special focus was on the dynamics and control of networks of systems, distributed optimization and formation control, fundamentals of nonlinear interconnected systems, as well as open problems in control

Discrete Time Systems

Discrete-Time Systems comprehend an important and broad research field. The consolidation of digital-based computational means in the present, pushes a technological tool into the field with a tremendous impact in areas like Control, Signal Processing, Communications, System Modelling and related Applications. This book attempts to give a scope in the wide area of Discrete-Time Systems. Their contents are grouped conveniently in sections according to significant areas, namely Filtering, Fixed and Adaptive Control Systems, Stability Problems and Miscellaneous Applications. We think that the contribution of the book enlarges the field of the Discrete-Time Systems with signification in the present state-of-the-art. Despite the vertiginous advance in the field, we also believe that the topics described here allow us also to look through some main tendencies in the next years in the research area

Distributed estimation techniques forcyber-physical systems

Nowadays, with the increasing use of wireless networks, embedded devices and agents with processing and sensing capabilities, the development of distributed estimation techniques has become vital to monitor important variables of the system that are not directly available. Numerous distributed estimation techniques have been proposed in the literature according to the model of the system, noises and disturbances. One of the main objectives of this thesis is to search all those works that deal with distributed estimation techniques applied to cyber-physical systems, system of systems and heterogeneous systems, through using systematic review methodology. Even though systematic reviews are not the common way to survey a topic in the control community, they provide a rigorous, robust and objective formula that should not be ignored. The presented systematic review incorporates and adapts the guidelines recommended in other disciplines to the field of automation and control and presents a brief description of the different phases that constitute a systematic review. Undertaking the systematic review many gaps were discovered: it deserves to be remarked that some estimators are not applied to cyber-physical systems, such as sliding mode observers or set-membership observers. Subsequently, one of these particular techniques was chosen, set-membership estimator, to develop new applications for cyber-physical systems. This introduces the other objectives of the thesis, i.e. to present two novel formulations of distributed set-membership estimators. Both estimators use a multi-hop decomposition, so the dynamics of the system is rewritten to present a cascaded implementation of the distributed set-membership observer, decoupling the influence of the non-observable modes to the observable ones. So each agent must find a different set for each sub-space, instead of a unique set for all the states. Two different approaches have been used to address the same problem, that is, to design a guaranteed distributed estimation method for linear full-coupled systems affected by bounded disturbances, to be implemented in a set of distributed agents that need to communicate and collaborate to achieve this goal