127 research outputs found
Basic Research in Endocrinology
The first all-Russia conference with international participation “Basic Research in Endocrinology: A Modern Strategy for the Development and Technologies of Personalized Medicine” was held in Novosibirsk on 26–27 November 2020. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of endocrine disorders among various relevant specialists. The conference was intended for practicing endocrinologists, primary care physicians, medical geneticists, pediatric endocrinologists, pediatricians, and physician–scientists. The main topics included epidemiology and pathogenesis of endocrine disorders; genomic research in endocrinology; biochemical characteristics of endocrine aberrations; immunology and immunogenetics in endocrinology; cellular technologies in endocrinology; metabolomic research in endocrinology; pharmacogenetics; basic pathomorphology; high-tech care of patients with endocrine disorders; iodine-deficiency-related, autoimmune, and oncological diseases of the thyroid; modern diagnostic and therapeutic strategies for diabetes mellitus; osteoporosis and osteopenias; polyendocrinopathies; an interdisciplinary approach to the diagnosis and treatment of obesity and metabolic syndrome; hypo- and hyperparathyroidism, vitamin D; neuroendocrine disorders; reproductive health; rehabilitation of patients with endocrine disorders; health resort and spa treatments of endocrine disorders and comorbid conditions
Contributions on metric spaces with applications in personalized medicine
Esta tesis tiene como objetivo proponer nuevas
representaciones distribucionales y métodos estadísticos en
espacios métricos para modelar de forma eficaz los datos
procedentes de la monitorización continua de los pacientes
durante las actividades propias de su vida diaria. Proponemos
nuevas pruebas de hipótesis para datos emparejados, modelos
de regresión, algoritmos de cuantificación de la incertidumbre,
pruebas de independencia estadística y algoritmos de análisis
de conglomerados para las nuevas representaciones
distribucionales y otros objetos estadísticos complejos. Los
diferentes resultados recogidos a lo largo de la tesis muestran
las ventajas en términos de predicción, interpretabilidad y
capacidad de modelización de las nuevas propuestas frente a
los metodos existentes
Recent Advances in Gestational Diabetes Mellitus
The papers included in this issue vary from research on pregnancy outcomes to screening and diagnosis of GDM, the use of new biomarkers, and the evaluation of long-term metabolic risk and intervention strategies postpartum in mothers and offspring
Proceeding for Recent Trends in Biomedical Sciences-2018 (RTBS-2018)
Organised by Department of Medical Laboratory Sciences, Lovely Professional University PunjabSmt. Shanti Devi Mittal Auditorium, Lovely Professional University Punjabon 16th March 2018 (Friday
Ischemic Heart Disease in the Context of Different Comorbidities
Ischemic heart disease is a cardiovascular condition with very high prevalence worldwide and a major source of morbidity and mortality, especially in the geriatric population. The management of coronary artery disease is one that requires high-level expertise. The presence of comorbidities, usually multiple at advanced ages, makes the diagnosis and therapy very challenging. In this setting, the effort of a multidisciplinary team is urgently needed to achieve integrated management of these cases, being the only one capable of leading to the best results for the patient.The purpose of this reprint is to bring together the experience of specialists in treating ischemic heart disease in the presence of major related conditions that require particular modulations of diagnostic and therapeutic interventions. The chapters address difficult areas of interference between ischemic heart disease and frailty, cancer, liver diseases, inflammatory bowel disease and the new SARS-CoV-2 infection. Special consideration is granted to cardiac remodeling and progression to heart failure. Niche topics such as acute coronary syndromes triggered by carbon monoxide poisoning are present as well. The book also contains a particularly interesting chapter dedicated to the genetic substrate of ischemic heart disease, which once again emphasizes the need for a multidisciplinary team approach to this disease.We consider the reprint an excellent source of information for medical practitioners who have to solve complex cases of ischemic heart disease
Recommended from our members
The Relationship between Cardiometabolic Disorders and Schizophrenia: From Early-Life Origins to the Development of a Cardiometabolic Risk Prediction Algorithm for Young People with Psychosis
My thesis considers the theme of comorbidity between cardiometabolic disorders and schizophrenia
by focussing on three key aspects: the nature of association between cardiometabolic disorders and
schizophrenia; the potential for common underlying biological mechanisms for the comorbidity; and
the prediction of cardiometabolic risk in young adults with psychosis.
On the nature of association between cardiometabolic disorders and schizophrenia, using longitudinal
repeat measure data from a large birth cohort, I found that disruption to glucose-insulin homeostasis
through childhood/adolescence is associated with increased risk of psychosis in early-adulthood; may
not be fully explained by common sociodemographic and lifestyle factors; and may be specific to it.
On the mechanisms of association between cardiometabolic disorders and schizophrenia, I used a
range of genetic and observational epidemiological methods to examine whether inflammation and
shared genetic liability may be common underlying biological mechanisms for the comorbidity.
Using birth cohort data, I show that genetic risk for type 2 diabetes is associated with psychosis-risk
in adulthood, and vice versa. I also show that genetic risk for type 2 diabetes may influence psychosis
risk by increasing systemic inflammation. Using summary data from large genome-wide association
studies (GWAS), I show a thread of evidence for shared genetic overlap between schizophrenia,
cardiometabolic and inflammatory traits. Finally, using Mendelian randomization, I show evidence
supporting that inflammation may be a common cause for insulin resistance and schizophrenia.
On the prediction of cardiometabolic risk in young adults with psychosis, I performed a systematic
review of cardiometabolic risk prediction algorithms and explored their predictive performance in a
sample of young people at risk of developing psychosis. In doing so, I show that none are likely to
be suitable for this population. Then, using patient data, I developed and externally validated the
Psychosis Metabolic Risk Calculator (PsyMetRiC), the first cardiometabolic risk prediction
algorithm specifically tailored for young people with psychosis.
Together, my work suggests that cardiometabolic disorders and schizophrenia share aetiologic
mechanisms, namely inflammation and shared genetic liability. I have shown that it is possible to
accurately predict cardiometabolic risk in young people with psychosis using a tool tailored for the
population. Such tools can in future become valuable resources for clinicians to reduce the risk of
long-term cardiometabolic morbidity and mortality in people with schizophrenia.National Institute for Health Research (NIHR) Doctoral Research Fellowshi
Prevention and Treatment of Atherosclerosis
This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets
Non-communicable Diseases, Big Data and Artificial Intelligence
This reprint includes 15 articles in the field of non-communicable Diseases, big data, and artificial intelligence, overviewing the most recent advances in the field of AI and their application potential in 3P medicine
Prevention and Treatment of Atherosclerosis
This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets
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