17,661 research outputs found
Learning-based Single-step Quantitative Susceptibility Mapping Reconstruction Without Brain Extraction
Quantitative susceptibility mapping (QSM) estimates the underlying tissue
magnetic susceptibility from MRI gradient-echo phase signal and typically
requires several processing steps. These steps involve phase unwrapping, brain
volume extraction, background phase removal and solving an ill-posed inverse
problem. The resulting susceptibility map is known to suffer from inaccuracy
near the edges of the brain tissues, in part due to imperfect brain extraction,
edge erosion of the brain tissue and the lack of phase measurement outside the
brain. This inaccuracy has thus hindered the application of QSM for measuring
the susceptibility of tissues near the brain edges, e.g., quantifying cortical
layers and generating superficial venography. To address these challenges, we
propose a learning-based QSM reconstruction method that directly estimates the
magnetic susceptibility from total phase images without the need for brain
extraction and background phase removal, referred to as autoQSM. The neural
network has a modified U-net structure and is trained using QSM maps computed
by a two-step QSM method. 209 healthy subjects with ages ranging from 11 to 82
years were employed for patch-wise network training. The network was validated
on data dissimilar to the training data, e.g. in vivo mouse brain data and
brains with lesions, which suggests that the network has generalized and
learned the underlying mathematical relationship between magnetic field
perturbation and magnetic susceptibility. AutoQSM was able to recover magnetic
susceptibility of anatomical structures near the edges of the brain including
the veins covering the cortical surface, spinal cord and nerve tracts near the
mouse brain boundaries. The advantages of high-quality maps, no need for brain
volume extraction and high reconstruction speed demonstrate its potential for
future applications.Comment: 26 page
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Coil combination using linear deconvolution in k-space for phase imaging
Background: The combination of multi-channel data is a critical step for the imaging of phase and susceptibility contrast in magnetic resonance imaging (MRI). Magnitude-weighted phase combination methods often produce noise and aliasing artifacts in the magnitude images at accelerated imaging sceneries. To address this issue, an optimal coil combination method through deconvolution in k-space is proposed in this paper.
Methods: The proposed method firstly employs the sum-of-squares and phase aligning method to yield a complex reference coil image which is then used to calculate the coil sensitivity and its Fourier transform. Then, the coil k-space combining weights is computed, taking into account the truncated frequency data of coil sensitivity and the acquired k-space data. Finally, combining the coil k-space data with the acquired weights generates the k-space data of proton distribution, with which both phase and magnitude information can be obtained straightforwardly. Both phantom and in vivo imaging experiments were conducted to evaluate the performance of the proposed method.
Results: Compared with magnitude-weighted method and MCPC-C, the proposed method can alleviate the phase cancellation in coil combination, resulting in a less wrapped phase.
Conclusions: The proposed method provides an effective and efficient approach to combine multiple coil image in parallel MRI reconstruction, and has potential to benefit routine clinical practice in the future
Recommended Implementation of Quantitative Susceptibility Mapping for Clinical Research in The Brain: A Consensus of the ISMRM Electro-Magnetic Tissue Properties Study Group
This article provides recommendations for implementing quantitative susceptibility mapping (QSM) for clinical brain research. It is a consensus of the ISMRM Electro-Magnetic Tissue Properties Study Group. While QSM technical development continues to advance rapidly, the current QSM methods have been demonstrated to be repeatable and reproducible for generating quantitative tissue magnetic susceptibility maps in the brain. However, the many QSM approaches available give rise to the need in the neuroimaging community for guidelines on implementation. This article describes relevant considerations and provides specific implementation recommendations for all steps in QSM data acquisition, processing, analysis, and presentation in scientific publications. We recommend that data be acquired using a monopolar 3D multi-echo GRE sequence, that phase images be saved and exported in DICOM format and unwrapped using an exact unwrapping approach. Multi-echo images should be combined before background removal, and a brain mask created using a brain extraction tool with the incorporation of phase-quality-based masking. Background fields should be removed within the brain mask using a technique based on SHARP or PDF, and the optimization approach to dipole inversion should be employed with a sparsity-based regularization. Susceptibility values should be measured relative to a specified reference, including the common reference region of whole brain as a region of interest in the analysis, and QSM results should be reported with - as a minimum - the acquisition and processing specifications listed in the last section of the article. These recommendations should facilitate clinical QSM research and lead to increased harmonization in data acquisition, analysis, and reporting
Fast quantitative susceptibility mapping with L1-regularization and automatic parameter selection
Purpose
To enable fast reconstruction of quantitative susceptibility maps with total variation penalty and automatic regularization parameter selection.
Methods
â„“[subscript 1]-Regularized susceptibility mapping is accelerated by variable splitting, which allows closed-form evaluation of each iteration of the algorithm by soft thresholding and fast Fourier transforms. This fast algorithm also renders automatic regularization parameter estimation practical. A weighting mask derived from the magnitude signal can be incorporated to allow edge-aware regularization.
Results
Compared with the nonlinear conjugate gradient (CG) solver, the proposed method is 20 times faster. A complete pipeline including Laplacian phase unwrapping, background phase removal with SHARP filtering, and ℓ[subscript 1]-regularized dipole inversion at 0.6 mm isotropic resolution is completed in 1.2 min using MATLAB on a standard workstation compared with 22 min using the CG solver. This fast reconstruction allows estimation of regularization parameters with the L-curve method in 13 min, which would have taken 4 h with the CG algorithm. The proposed method also permits magnitude-weighted regularization, which prevents smoothing across edges identified on the magnitude signal. This more complicated optimization problem is solved 5 times faster than the nonlinear CG approach. Utility of the proposed method is also demonstrated in functional blood oxygen level–dependent susceptibility mapping, where processing of the massive time series dataset would otherwise be prohibitive with the CG solver.
Conclusion
Online reconstruction of regularized susceptibility maps may become feasible with the proposed dipole inversion
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Development of Deep Learning Methods for Magnetic Resonance Phase Imaging of Neurological Disease
Magnetic resonance imaging (MRI) is a high-resolution, non-invasive medical imaging modality that is widely used in human brain. In recent years, susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM) have been proposed to utilize MR phase signal to generate contrast from tissue magnetic susceptibility and even quantify the property. On the other hand, deep learning, especially deep convolutional neural networks (DCNNs), have achieved state-of-the-art performances in numerous computer vision tasks and gained significant attention in the field of medical imaging in the recent years. This dissertation combined the idea of deep learning with the two MR phase imaging methods. To combined deep learning with SWI, we designed and trained a 3D deep residual network that can distinguish false positive detected candidates from cerebral microbleeds (CMBs) and built an automatic CMB detection pipeline with high performance. We further confirmed the generalizability of this deep learning-based pipeline using multiple dataset with different scan parameters and pathologies and provided lessons for application and generalization of generic deep learning based medical imaging methods.To combine deep learning with QSM, we developed a 3D U-Net based network that learns to perform dipole inversion from gold standard QSM acquired from data with multiple orientation. The model was further improved with adversarial training strategy and achieved significantly lower reconstruction error than traditional QSM algorithms. In addition, we also performed various background removal and dipole inversion algorithms on both brain tumor patients and healthy volunteers to study and compare their performances. The results could provide guidance on future application of QSM in different scenarios
Fast image reconstruction with L2-regularization
Purpose
We introduce L2-regularized reconstruction algorithms with closed-form solutions that achieve dramatic computational speed-up relative to state of the art L1- and L2-based iterative algorithms while maintaining similar image quality for various applications in MRI reconstruction.
Materials and Methods
We compare fast L2-based methods to state of the art algorithms employing iterative L1- and L2-regularization in numerical phantom and in vivo data in three applications; (i) Fast Quantitative Susceptibility Mapping (QSM), (ii) Lipid artifact suppression in Magnetic Resonance Spectroscopic Imaging (MRSI), and (iii) Diffusion Spectrum Imaging (DSI). In all cases, proposed L2-based methods are compared with the state of the art algorithms, and two to three orders of magnitude speed up is demonstrated with similar reconstruction quality.
Results
The closed-form solution developed for regularized QSM allows processing of a three-dimensional volume under 5 s, the proposed lipid suppression algorithm takes under 1 s to reconstruct single-slice MRSI data, while the PCA based DSI algorithm estimates diffusion propagators from undersampled q-space for a single slice under 30 s, all running in Matlab using a standard workstation.
Conclusion
For the applications considered herein, closed-form L2-regularization can be a faster alternative to its iterative counterpart or L1-based iterative algorithms, without compromising image quality.National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant NIBIB K99EB012107)National Institutes of Health (U.S.) (Grant NIH R01 EB007942)National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant NIBIB R01EB006847)Grant K99/R00 EB008129National Center for Research Resources (U.S.) (Grant NCRR P41RR14075)National Institutes of Health (U.S.) (Blueprint for Neuroscience Research U01MH093765)Siemens CorporationSiemens-MIT AllianceMIT-Center for Integration of Medicine and Innovative Technology (Medical Engineering Fellowship
Quantitative Susceptibility Mapping: Contrast Mechanisms and Clinical Applications.
Quantitative susceptibility mapping (QSM) is a recently developed MRI technique for quantifying the spatial distribution of magnetic susceptibility within biological tissues. It first uses the frequency shift in the MRI signal to map the magnetic field profile within the tissue. The resulting field map is then used to determine the spatial distribution of the underlying magnetic susceptibility by solving an inverse problem. The solution is achieved by deconvolving the field map with a dipole field, under the assumption that the magnetic field is a result of the superposition of the dipole fields generated by all voxels and that each voxel has its unique magnetic susceptibility. QSM provides improved contrast to noise ratio for certain tissues and structures compared to its magnitude counterpart. More importantly, magnetic susceptibility is a direct reflection of the molecular composition and cellular architecture of the tissue. Consequently, by quantifying magnetic susceptibility, QSM is becoming a quantitative imaging approach for characterizing normal and pathological tissue properties. This article reviews the mechanism generating susceptibility contrast within tissues and some associated applications
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