Towards self-organizing logistics in transportation:a literature review and typology

Deploying self-organizing systems is a way to cope with the logistics sector's complex, dynamic, and stochastic nature. In such systems, automated decision-making and decentralized or distributed control structures are combined. Such control structures reduce the complexity of decision-making, require less computational effort, and are therefore faster, reducing the risk that changes during decision-making render the solution invalid. These benefits of self-organizing systems are of interest to many practitioners involved in solving real-world problems in the logistics sector. This study, therefore, identifies and classifies research related to self-organizing logistics (SOL) with a focus on transportation. SOL is an interdisciplinary study across many domains and relates to other concepts, such as agent-based systems, autonomous control, and decentral systems. Yet, few papers directly identify this as self-organization. Hence, we add to the existing literature by conducting a systematic literature review that provides insight into the field of SOL. The main contribution of this paper is two-fold: (i) based on the findings from the literature review, we identify and synthesize 15 characteristics of SOL in a typology, and (ii) we present a two-dimensional SOL framework alongside the axes of autonomy and cooperativity to position and contrast the broad range of literature, thereby creating order in the field of SOL and revealing promising research directions.</p

Advances in Reinforcement Learning

Reinforcement Learning (RL) is a very dynamic area in terms of theory and application. This book brings together many different aspects of the current research on several fields associated to RL which has been growing rapidly, producing a wide variety of learning algorithms for different applications. Based on 24 Chapters, it covers a very broad variety of topics in RL and their application in autonomous systems. A set of chapters in this book provide a general overview of RL while other chapters focus mostly on the applications of RL paradigms: Game Theory, Multi-Agent Theory, Robotic, Networking Technologies, Vehicular Navigation, Medicine and Industrial Logistic

Contributions to interoperability, scalability and formalization of personal health systems

The ageing of the world's population combined with unhealthy lifestyles are contributing to a major prevalence of chronic diseases. This scenario poses the challenge of providing good healthcare services to that people affected by chronic illnesses, but without increasing its costs. A prominent way to face this challenge is through pervasive healthcare. Research in pervasive healthcare tries to shift the current centralized healthcare delivery model focused on the doctors, to a more distributed model focused on the patients. In this context Personal Health Systems (PHSs) consists on approaching sampling technologies into the hands of the patients, without disturbing its activities of the daily life, to monitor patient's physiological parameters and providing feedback on their state. The use of PHSs involves the patients in the management of their illness and in their own well being too. The development of PHSs has to face technological issues in order to be accepted by our society. Within them it is important to ensure interoperability between different systems in order to make them work together. Scalability it is also a concern, as their performance must not decrease when increasing the number of users. Another issue is how to formalize the medical knowledge for each patient, as different patients may have different target goals. Security and privacy are a must feature because of the sensitive nature of medical data. Other issues involve the the integration with legacy systems, and the usability of graphical user interfaces in order to encourage old people with the use these technologies. The aim of this PhD thesis is to contribute into the state-of-the-art of PHSs by tackling together different of the above-mentioned challenges. First, to achieve interoperability we use the CDA standard as a format to encode and exchange health data and alerts related with the status of the patient. We show how these documents can be generated automatically through the use of XML templates. Second, we address the scalability by distributing the computations needed to monitor the patients over their devices, rather than performing them in a centralized server. In this context we develop the MAGPIE agent platform, which runs on Android devices, as a framework able to provide intelligence to PHSs, and generate alerts that can be of interest for the patients and the medical doctors. Third, we focus on the formalization of PHSs by providing a tool for the practitioners where they can define, in a graphical way, monitoring rules related with chronic diseases that are integrated with the MAGPIE agent platform. The thesis also explores different ways to share the data collected with PHSs in order to improve the outcomes obtained with the use of this technology. Data is shared between individuals following a Distributed Event-Based System (DEBS) approach, where different people can subscribe to the alerts produced by the patient. Data is also shared between institutions with a network protocol called MOSAIC, and we focus on the security aspects of this protocol. The research in this PhD focuses in the use case of Diabetes Mellitus; and it has been developed in the context of the projects MONDAINE, MAGPIE, COMMODITY12 and TAMESIS.L'envelliment de la població mundial combinat amb uns estils de vida no saludables contribueixen a una major prevalença d'enfermetats cròniques. Aquest escenari presenta el repte de proporcionar uns bons serveis sanitaris a les persones afectades per aquestes enfermetats, sense incrementar-ne els costos. Una solució prometedora a aquest repte és mitjançant l'aplicació del que en anglès s'anomena "pervasive healthcare". L'investigació en aquesta camp tracta de canviar l'actual model centralitzat de serveis sanitaris enfocat en el personal sanitari, per un model de serveis distribuït enfocat en els pacients. En aquest context, els Personal Health Systems (PHSs) consisteixen en posar a l'abast dels pacients les tecnologies de monitorització, i proporcionar-los informació sobre el seu estat. L'ús de PHSs involucra els pacients en la gestió de la seva enfermetat i del seu propi benestar. L'acceptació dels PHSs per part de la societat implica certs reptes tecnològics en el seu desenvolupament. És important garantir la seva interoperabilitat per tal de que puguin treballar conjuntament. La seva escalabilitat també s'ha de tenir en compte, ja que el seu rendiment no s'ha de veure afectat al incrementar-ne el número d'usuaris. Un altre aspecte a considerar és com formalitzar el coneixement mèdic per cada pacient, ja que cada un d'ells pot tenir objectius diferents. La seguretat i privacitat són característiques desitjades degut a la naturalesa sensible de les dades mèdiques. Altres problemàtiques impliquen la integració amb sistemes heretats, i la usabilitat de les interfícies gràfiques per fomentar-ne el seu ús entre les persones grans. L'objectiu d'aquesta tesi és contribuir a l'estat de l'art dels PHSs tractant de manera conjunta varis dels reptes mencionats. Per abordar l'interoperabilitat s'utilitza l'estàndard CDA com a format per codificar les dades mèdiques i alertes relacionades amb el pacient. A més es mostra com aquests documents poden generar-se de forma automàtica mitjançant l' ús de plantilles XML. Per tractar l'escalabilitat es distribueixen les computacions per monitoritzar els pacients entre els seus terminals mòbils, en comptes de realitzar-les en un servidor central. En aquest context es desenvolupa la plataforma d'agents MAGPIE com a framework per proporcionar intelligència als PHSs i generar alertes d'interès per al metge i el pacient. La formalització s'aborda mitjançant una eina que permet als metges definir de manera gràfica regles de monitorització relacionades amb enfermetats cròniques, que a més estan integrades amb la plataforma d'agents MAGPIE. La tesi també explora diferents maneres de compartir les dades recol·lectades amb un PHS, amb l'objectiu de millorar els resultats obtinguts amb aquesta tecnologia. Les dades es comparteixen entre individus seguint un enfoc de sistemes distribuïts basats en events (DEBS), on diferents usuaris poden subscriure's a les alertes produïdes per el pacient. Les dades també es comparteixen entre institucions mitjançant un protocol de xarxa anomenat MOSAIC. A la tesi es desenvolupen els aspectes de seguretat d'aquest protocol. La test es centra en la Diabetis Mellitus com a cas d'ús, i s'ha realitzat en el context dels projectes MONDAINE, MAGPIE, COMMODITY12 i TAMESIS.El envejecimiento de la población mundial combinado con unos estilos de vida no saludables contribuyen a una mayor prevalencia de enfermedades crónicas. Este escenario presenta el reto de proporcionar unos buenos servicios sanitarios a las personas afectadas por estas enfermedades, sin incrementar sus costes. Una solución prometedora a este reto es mediante la aplicación de lo que en inglés se denomina "pervasive healthcare". La investigación en este campo trata de cambiar el actual modelo centralizado de servicios sanitarios enfocado hacia el personal sanitario, por un modelo distribuido enfocado hacia los pacientes. En este contexto, los Personal Health Systems (PHSs) consisten en poner al alcance de los pacientes las tecnologías de monitorización, y proporcionarles información sobre su estado. El uso de PHSs involucra a los pacientes en la gestión de su enfermedad y en su propio bienestar. La aceptación de los PHSs por parte de la sociedad implica ciertos retos tecnológicos en su desarrollo. Es importante garantizar su interoperabilidad para que puedan trabajar conjuntamente. Su escalabilidad también se debe tener en cuenta, ya que su rendimiento no tiene que verse afectado al incrementar su número de usuarios. Otro aspecto a considerar es cómo formalizar el conocimiento médico para cada paciente, ya que cada uno puede tener objetivos distintos. La seguridad y privacidad son características deseadas debido a la naturaleza sensible de los datos médicos. Otras problemáticas implican la integración con sistemas heredados, y la usabilidad de las interfaces gráficas para fomentar su uso entre las personas mayores. El objetivo de esta tesis es contribuir al estado del arte de los PHSs tratando de manera conjunta varios de los retos mencionados. Para abordar la interoperabilidad se usa el estándar CDA como formato para codificar los datos médicos y alertas relacionados con el paciente. Además se muestra como estros documentos pueden generarse de forma automática mediante el uso de plantillas XML. Para tratar la escalabilidad se distribuye la computación para monitorizar a los pacientes en sus terminales móbiles, en lugar de realizarla en un servidor central. En este contexto se desarrolla la plataforma de agentes MAGPIE como framework para proporcionar inteligencia a los PHSs y generar alertas de interés para el médico y el paciente. La formalización se aborda mediante una herramienta que permite a los médicos definir de manera gráfica reglas de monitorización relacionadas con enfermedades crónicas, que ademas están integradas con la plataforma de agentes MAGPIE. La tesis también explora distintas formas de compartir los datos recolectados con un PHS, con el fin de mejorar los resultados obtenidos mediante esta tecnología. Los datos se comparten entre individuos siguiendo un enfoque de sistemas distribuidos basados en eventos (DEBS), donde distintos usuarios pueden suscribirse a las alertas producidas por el paciente. Los datos también se comparten entre instituciones mediante un protocolo dered llamado MOSAIC. En la tesis se desarrollan los aspectos de seguridad de este protocolo. La tesis se centra en la Diabetes Mellitus como caso de uso, y se ha realizado en el contexto de los proyectos MONDAINE, MAGPIE, COMMODITY12 y TAMESIS.Postprint (published version

Virtual Reality Games for Motor Rehabilitation

This paper presents a fuzzy logic based method to track user satisfaction without the need for devices to monitor users physiological conditions. User satisfaction is the key to any product’s acceptance; computer applications and video games provide a unique opportunity to provide a tailored environment for each user to better suit their needs. We have implemented a non-adaptive fuzzy logic model of emotion, based on the emotional component of the Fuzzy Logic Adaptive Model of Emotion (FLAME) proposed by El-Nasr, to estimate player emotion in UnrealTournament 2004. In this paper we describe the implementation of this system and present the results of one of several play tests. Our research contradicts the current literature that suggests physiological measurements are needed. We show that it is possible to use a software only method to estimate user emotion

Multi-objective Optimization Methods for Allocation and Prediction

In this thesis we focus on two different aspects of auctions and we employ techniques and methods from both operations research and computer science. _First,_ we study the allocation of tasks to agents at the end of an auction. Usually, tasks are allocated in such a way that minimizes the total cost for the auctioneer. This allocation is optimal in a one-shot auction, but if the auction is repeated, this can have negative consequences for the results in the long run. Therefore, we consider a fair allocation, which costs slightly more in a one-shot auction, but has positive effects on the participation level of agents and the total cost for the auctioneer in repeated auctions. _Second,_ we consider the auction design. How an auction is set up, like which tasks should be auctioned first, or what the starting price should be, impacts the result. Usually there are experts who know what has occurred in previous auctions and how a future auction should be designed in order to obtain the best results. However, historical auctions can obtain so much information that experts overlook things. We use a combination of machine learning and optimization models to extract information from historical auctions and use this information to help design future auctions for better results

Neuroprotective Effect of Hydroalcoholic Extract of Boerhaavia Diffusa Linn against MPTP Induced Neurodegenartion in Rats

The present study was undertaken to find out the potential activity of Boerhaavia diffusa against breast cancer and their effects on MPTP induced breast Neurodegenaration in rats. From time immemorial mankind's efforts and ultimate aim have been to seek eternal happiness. And his endeavour has been to overcome and seek appropriate remedies for things that stand in his way. Plants have played a weighty role in maintaining human health and improving the quality of human life for thousands of years and have several precious components of medicines, seasonings, beverages, cosmetics, and dyes. Herbal medicines are based on the premise that plants contain natural substance that can promote health and alleviate illness. In recent times focus on plant research has increased all over the world and large evidence has collected to show immense potential of medicinal plants used in various traditional systems. Today we are witnessing a great deal of public interest in the use of herbal remedies. Many western drugs had their origin in plant extract. There are many herbs, which are preponderantly used to treat cardiovascular problems, liver disorder, central nervous system, digestive system, metabolic disorders and for Neuroprotective effects. Given their potential to generate significant therapeutic effect, they can be useful as drug or supplement in the treatment in the management of many diseases. Herbal drug or medicinal plants, their extract and isolated compounds have demonstrated spectrum of biological activities. Such have been used and continued to be used as medicine in folk-fore or food supplement for various disorders. Boerhaavia diffusa (Punarnava) is one of the most famous medicinal plants in the treatment of a large number of human ailments is mentioned in Ayurveda, Charaka Samhita, and Sushrita Samhita. This work explains the evidence-based information regarding the pharmacological activity of this plant. It has many ethnobotanical uses (the leaves are used as vegetable; the root juice is used to cure asthma, urinary disorders, leukorrhea, rheumatism, and encephalitis). The Boerhaavia diffusa plant contains a large number of such compounds as flavonoids, alkaloids, steroids, triterpenoids, lipids, lignins, carbohydrates, proteins, and glycoproteins. Punarnavine, boeravinone, hypoxanthine 9-L-arabinofuranoside, ursolic acid, punarnavoside etc. Now this investigation was undertaken to study the effect of Boerhaavia diffusa on MPTP induced Neurodegenaration and also planned to study the changes occuring in the enzymic and non enzymic system such as super oxide dismutase, catalyase, glutathione peroxide and lipid peroxidation level present in the living body. CONCLUSION:In summary, findings of the present study provide evidence that HAEBD at the dose of 400mg/kg p.o alleviates behavioral deficits. It also reduced the oxidative parameter and enhances the brain antioxidants, significantly prevents the brain from neurotoxic effects. Therefore, Hydroalcoholic extract of Boerhaavia diffusa Linn contains flavanoids and polyphenols was considered as powerful neuroprotective agent could offer a useful support to the Parkinsonism therapy