In-Suit Doppler Technology Assessment

The objective of this program was to perform a technology assessment survey of non-invasive air embolism detection utilizing Doppler ultrasound methodologies. The primary application of this technology will be a continuous monitor for astronauts while performing extravehicular activities (EVA's). The technology assessment was to include: (1) development of a full understanding of all relevant background research; and (2) a survey of the medical ultrasound marketplace for expertise, information, and technical capability relevant to this development. Upon completion of the assessment, LSR was to provide an overview of technological approaches and R&D/manufacturing organizations

Development of a surrogate bruising detection system to describe potential bruising patterns associated with common childhood falls.

Child abuse is a leading cause of fatality in children aged 0-4 years. An estimated 1,700 children die annually as a result of child abuse of which threequarters (75.7%) of the children were younger than 4 years old1. Infants (younger than 1 year) had the highest rate of fatalities among the group. Many of the serious injuries and fatalities could have potentially been prevented if clinicians and child protective services were able to better distinguish between injuries associated with abuse versus those caused by accidents. Missed cases of child abuse have been shown to be as high as 71% of all admitted cases, where children are presented at hospitals for their injuries and not evaluated as being abused 2. Additionally, when child abuse is legally pursued for criminal charges, a little more than half of the cases move forward to prosecution as opposed to being screened out for reasons including the need for further investigation or insufficient evidence 3. Therefore there is a need to provide clinicians, child protective services and law enforcement personnel with improved knowledge related to the types of injuries that are possible from common household accidents that are often reported to be the underlying cause of injury in child abuse. Bruising is an early sign of abuse, and can be an effective indicator of child abuse. Although not life threatening, bruising injuries or bruising patterns provide a “roadmap” documenting a child’s exposure to impact. Previous research has relied upon the use of instrumented anthropomorphic test devices, or test dummies, to investigate injury risk in common childhood falls and accidents in addition to head injury and bone fracture risk in children 4-7. However, the ability to predict bruising patterns occurring in association with falsely reported events in child abuse does not exist, and could prove extremely useful in the distinction between abusive and accidental injuries. This study required the modification of an existing pediatric test dummy to allow for the prediction of potential bruising locations and bruising patterns in children during common household fall events that are often stated as false scenarios in child abuse. The scope of this project included the development of a “sensing skin” that was adapted to a commercial pediatric test dummy. This modified test dummy was then used in mock laboratory experiments replicating common household injury events while the “sensing skin” measured and recorded levels of impact force and locations of impact on the human surrogate. The data from the “sensing skin” was acquired and compiled in a computerized visual body map image displaying the areas of contact or impact locations. This body map image provided a “roadmap” of the human surrogate’s contact exposure during the specific fall event and defined a compatible impact roadmap–specific event combination. Impact roadmap–event combinations for various common household falls provide an indication of where potential bruising could occur. This knowledge of potential bruising patterns could aid clinicians in distinguishing between abusive and accidental injuries for specific fall types

Advanced Applications of Rapid Prototyping Technology in Modern Engineering

Rapid prototyping (RP) technology has been widely known and appreciated due to its flexible and customized manufacturing capabilities. The widely studied RP techniques include stereolithography apparatus (SLA), selective laser sintering (SLS), three-dimensional printing (3DP), fused deposition modeling (FDM), 3D plotting, solid ground curing (SGC), multiphase jet solidification (MJS), laminated object manufacturing (LOM). Different techniques are associated with different materials and/or processing principles and thus are devoted to specific applications. RP technology has no longer been only for prototype building rather has been extended for real industrial manufacturing solutions. Today, the RP technology has contributed to almost all engineering areas that include mechanical, materials, industrial, aerospace, electrical and most recently biomedical engineering. This book aims to present the advanced development of RP technologies in various engineering areas as the solutions to the real world engineering problems

Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery

Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor resection that necessitates repeat surgery. Sentinel lymph node biopsy by conventional radioactive tracking exposes patients and caregivers to ionizing radiation, while blue dye tracking stains the tissue highlighting only superficial lymph nodes. Improper identification of sentinel lymph nodes may misdiagnose the stage of the cancer. Therefore there is a clinical need for accurate intraoperative tumor and sentinel lymph node visualization. Conventional imaging modalities such as x-ray computed tomography, positron emission tomography, magnetic resonance imaging, and ultrasound are excellent for preoperative cancer diagnosis and surgical planning. However, they are not suitable for intraoperative use, due to bulky complicated hardware, high cost, non-real-time imaging, severe restrictions to the surgical workflow and lack of sufficient resolution for tumor boundary assessment. This has propelled interest in fluorescence-guided surgery, due to availability of simple hardware that can achieve real-time, high resolution and sensitive imaging. Near-infrared fluorescence imaging is of particular interest due to low background absorbance by photoactive biomolecules, enabling thick tissue assessment. As a result several near-infrared fluorescence-guided surgery systems have been developed. However, they are limited by bulky hardware, disruptive information display and non-matched field of view to the user. To address these limitations we have developed a compact, light-weight and wearable goggle augmented imaging and navigation system (GAINS). It detects the near-infrared fluorescence from a tumor accumulated contrast agent, along with the normal color view and displays accurately aligned, color-fluorescence images via a head-mounted display worn by the surgeon, in real-time. GAINS is a platform technology and capable of very sensitive fluorescence detection. Image display options include both video see-through and optical see-through head-mounted displays for high-contrast image guidance as well as direct visual access to the surgical bed. Image capture options from large field of view camera as well high magnification handheld microscope, ensures macroscopic as well as microscopic assessment of the tumor bed. Aided by tumor targeted near-infrared contrast agents, GAINS guided complete tumor resection in subcutaneous, metastatic and spontaneous mouse models of cancer with high sensitivity and specificity, in real-time. Using a clinically-approved near-infrared contrast agent, GAINS provided real-time image guidance for accurate visualization of lymph nodes in a porcine model and sentinel lymph nodes in human breast cancer and melanoma patients with high sensitivity. This work has addressed issues that have limited clinical adoption of fluorescence-guided surgery and paved the way for research into developing this approach towards standard-of-care practice that can potentially improve surgical outcomes in cancer

Radiological Society of North America (RSNA) 3D printing Special Interest Group (SIG): Guidelines for medical 3D printing and appropriateness for clinical scenarios

Este número da revista Cadernos de Estudos Sociais estava em organização quando fomos colhidos pela morte do sociólogo Ernesto Laclau. Seu falecimento em 13 de abril de 2014 surpreendeu a todos, e particularmente ao editor Joanildo Burity, que foi seu orientando de doutorado na University of Essex, Inglaterra, e que recentemente o trouxe à Fundação Joaquim Nabuco para uma palestra, permitindo que muitos pudessem dialogar com um dos grandes intelectuais latinoamericanos contemporâneos. Assim, buscamos fazer uma homenagem ao sociólogo argentino publicando uma entrevista inédita concedida durante a sua passagem pelo Recife, em 2013, encerrando essa revista com uma sessão especial sobre a sua trajetória

2007 Annual Research Symposium Abstract Book

2007 annual volume of abstracts for science research projects conducted by students at Trinity College

The characteristics of the CAT to CAD to rapid prototyping system

ThesisComputer Aided Design (CAD), Rapid Prototyping (RP) and Computer Aided Tomography (CAT) technologies were researched. The project entails a unique combination of the abovementioned technologies, which had to be mastered by the author, on local and international terms. Nine software packages were evaluated to determine the modus operandi, required input and final output results. Fifty Rapid Prototyping systems were investigated to determine the strong and weak areas of the various systems, which showed that prototype materials, machine cost and growing time play an essential role. Thirty Reverse Engineering systems were also researched. Six different RE methods were recorded with several commercial systems available. Nineteen case studies were completed by using several different Computer Aided Tomography (CAT) and Magnetic Resonance Imaging (MRI) centers. Each scanning centre has different apparatus and is discussed in detail in the various case studies. The focus of this project is the data transfer of two dimensional CAT scanning data to threedimensional prototypes by using Reverse Engineering (RE) and Rapid Prototyping (RP). It is therefore of cardinal importance that one is familiar and understands the various fields of interest namely Reverse Engineering, Computer Aided Tomography and Rapid Prototyping. Each of these fields will be discussed in detail, with the latest developments in these fields covered as well. Case studies and research performed in the medical field should gain the medical industry's confidence. Constant marketing and publications will ensure that the technology is applied and transferred to the industry. Commercialisation of the technology is of utmost importanc