Individual Nurse Productivity in Preparing Patients for Discharge Is Associated with Patient Likelihood of 30-Day Return to Hospital

Objective: Applied to value-based health care, the economic term “individual productivity” refers to the quality of an outcome attributable through a care process to an individual clinician. This study aimed to (1) estimate and describe the discharge preparation productivities of individual acute care nurses and (2) examine the association between the discharge preparation productivity of the discharging nurse and the patient’s likelihood of a 30-day return to hospital [readmission and emergency department (ED) visits]. Research Design: Secondary analysis of patient-nurse data from a cluster-randomized multisite study of patient discharge readiness and readmission. Patients reported discharge readiness scores; postdischarge outcomes and other variables were extracted from electronic health records. Using the structure-process-outcomes model, we viewed patient readiness for hospital discharge as a proximal outcome of the discharge preparation process and used it to measure nurse productivity in discharge preparation. We viewed hospital return as a distal outcome sensitive to discharge preparation care. Multilevel regression analyses used a split-sample approach and adjusted for patient characteristics. Subjects: A total 522 nurses and 29,986 adult (18+ y) patients discharged to home from 31 geographically diverse medical-surgical units between June 15, 2015 and November 30, 2016. Measures: Patient discharge readiness was measured using the 8-item short form of Readiness for Hospital Discharge Scale (RHDS). A 30-day hospital return was a categorical variable for an inpatient readmission or an ED visit, versus no hospital return. Results: Variability in individual nurse productivity explained 9.07% of variance in patient discharge readiness scores. Nurse productivity was negatively associated with the likelihood of a readmission (−0.48 absolute percentage points, P\u3c0.001) and an ED visit (−0.29 absolute percentage points, P=0.042). Conclusions: Variability in individual clinician productivity can have implications for acute care quality patient outcomes

Type 2 myocardial infarction: the chimaera of cardiology?

The term type 2 myocardial infarction first appeared as part of the universal definition of myocardial infarction. It was introduced to cover a group of patients who had elevation of cardiac troponin but did not meet the traditional criteria for acute myocardial infarction although they were considered to have an underlying ischaemic aetiology for the myocardial damage observed. Since first inception, the term type 2 myocardial infarction has always been vague. Although attempts have been made to produce a systematic definition of what constitutes a type 2 myocardial infarction, it has been more often characterised by what it is not rather than what it is. Clinical studies that have used type 2 myocardial infarction as a diagnostic criterion have produced disparate incidence figures. The range of associated clinical conditions differs from study to study. Additionally, there are no agreed or evidence-based treatment strategies for type 2 myocardial infarction. The authors believe that the term type 2 myocardial infarction is confusing and not evidence-based. They consider that there is good reason to stop using this term and consider instead the concept of secondary myocardial injury that relates to the underlying pathophysiology of the primary clinical condition

Effect of Preventive Primary Care Outreach on Health Related Quality of Life Among Older Adults at Risk of Functional Decline: Randomised Controlled Trial

Objective: To evaluate the impact of a provider initiated primary care outreach intervention compared with usual care among older adults at risk of functional decline. Design: Randomised controlled trial. Setting: Patients enrolled with 35 family physicians in five primary care networks in Hamilton, Ontario, Canada. Participants: Patients were eligible if they were 75 years of age or older and were not receiving home care services. Of 3166 potentially eligible patients, 2662 (84%) completed the validated postal questionnaire used to determine risk of functional decline. Of 1724 patients who met the risk criteria, 769 (45%) agreed to participate and 719 were randomised. Intervention: The 12 month intervention, provided by experienced home care nurses in 2004-6, consisted of a comprehensive initial assessment using the resident assessment instrument for home care; collaborative care planning with patients, their families, and family physicians; health promotion; and referral to community health and social support services. Main outcome measures: Quality adjusted life years (QALYs), use and costs of health and social services, functional status, self rated health, and mortality. Results: The mean difference in QALYs between intervention and control patients during the study period was not statistically significant (0.017, 95% confidence interval ?0.022 to 0.056; P=0.388). The mean difference in overall cost of prescription drugs and services between the intervention and control groups was not statistically significant, (-$C165 (£107; 118;$162), 95% confidence interval -$C16 545 to$$16 214; P=0.984). Changes over 12 months in functional status and self rated health were not significantly different between the intervention and control groups. Ten patients died in each group. Conclusions: The results of this study do not support adoption of this preventive primary care intervention for this target population of high risk older adults

Incremental willingness to pay: a theoretical and empirical exposition

Applications of willingness to pay (WTP) have shown the difficultly to discriminate between various options. This reflects the problem of embedding in both its specific sense, of options being nested within one another, and its more-general sense, whereby respondents cannot discriminate between close substitutes or between more-disparate rivals for the same budget. Furthermore, high proportions of reversals between WTP-value and simple preference based rankings of options are often highlighted. Although an incremental WTP approach was devised to encourage more differentiated answers and a higher degree of consistency among respondents, a theoretical basis for this approach has not been elucidated, and there is little evidence to show that this approach might indeed achieve greater consistency between explicit and implicit rankings inferred from WTP values.We address both these issues. Following our theoretical exposition, standard and incremental approaches were compared with explicit ranking in a study assessing preferences for different French emergency care services. 280 persons, representative of the French adult population, were interviewed. Half received the incremental version, the other half the standard version. Results suggest that the incremental approach provides a ranking of options fully in line with explicit ranking. The standard approach was reasonably consistent with explicit ranking but proved unable to differentiate between the five most preferred providers, as predicted by theory. Our findings suggest that the incremental approach provides results which can be used in priority-setting contexts

Randomized controlled trial of a coordinated care intervention to improve risk factor control after stroke or transient ischemic attack in the safety net: Secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED).

BackgroundRecurrent strokes are preventable through awareness and control of risk factors such as hypertension, and through lifestyle changes such as healthier diets, greater physical activity, and smoking cessation. However, vascular risk factor control is frequently poor among stroke survivors, particularly among socio-economically disadvantaged blacks, Latinos and other people of color. The Chronic Care Model (CCM) is an effective framework for multi-component interventions aimed at improving care processes and outcomes for individuals with chronic disease. In addition, community health workers (CHWs) have played an integral role in reducing health disparities; however, their effectiveness in reducing vascular risk among stroke survivors remains unknown. Our objectives are to develop, test, and assess the economic value of a CCM-based intervention using an Advanced Practice Clinician (APC)-CHW team to improve risk factor control after stroke in an under-resourced, racially/ethnically diverse population.Methods/designIn this single-blind randomized controlled trial, 516 adults (≥40 years) with an ischemic stroke, transient ischemic attack or intracerebral hemorrhage within the prior 90 days are being enrolled at five sites within the Los Angeles County safety-net setting and randomized 1:1 to intervention vs usual care. Participants are excluded if they do not speak English, Spanish, Cantonese, Mandarin, or Korean or if they are unable to consent. The intervention includes a minimum of three clinic visits in the healthcare setting, three home visits, and Chronic Disease Self-Management Program group workshops in community venues. The primary outcome is blood pressure (BP) control (systolic BP <130 mmHg) at 1 year. Secondary outcomes include: (1) mean change in systolic BP; (2) control of other vascular risk factors including lipids and hemoglobin A1c, (3) inflammation (C reactive protein [CRP]), (4) medication adherence, (5) lifestyle factors (smoking, diet, and physical activity), (6) estimated relative reduction in risk for recurrent stroke or myocardial infarction (MI), and (7) cost-effectiveness of the intervention versus usual care.DiscussionIf this multi-component interdisciplinary intervention is shown to be effective in improving risk factor control after stroke, it may serve as a model that can be used internationally to reduce race/ethnic and socioeconomic disparities in stroke in resource-constrained settings.Trial registrationClinicalTrials.gov Identifier NCT01763203

Identification and Characterization of Neuropsychological Phenotypes in Sport-Related Concussion

OBJECTIVES: Sport-related concussion (SRC) is a mild form of neurotrauma, resulting in transient cognitive deficits and symptoms. Staggering heterogeneity in its clinical manifestation has been observed in practice. The purpose of the current study was to attempt to empirically elucidate neuropsychological subgroups of SRC. METHODS: An archival consecutive clinical case series of 1366 (872 male, 494 female; Mage=15.6, SDage=1.9) post-concussion athletes, referred for neuropsychological testing was utilized in this study. Athletes were administered the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT), including the Post-Concussion Symptom Scale (PCSS). A priori analyses included Latent Class Analysis (LCA), and post-hoc analyses included cluster analysis, ANOVA and MANOVA. RESULTS: The LCA revealed no definite structure in the data, in either the overall sample or an acute sample (≤7 days post-concussion). There was vast disagreement between fit indices, with some indicating no cluster solution was appropriate. Cluster analysis yielded two cluster solutions, both of which primarily reflected levels of performance rather than distinct neuropsychological clusters. However, one cluster from each sample was comprised of poor cognitive scores and low symptom reporting. CONCLUSIONS: No distinct neuropsychological profiles emerged from the data. Although there was one potentially interesting cluster from each of the solutions, the majority of solutions reflected levels of performance and reporting. Although it is possible that there are no subgroups of SRC, this question is far from resolved

Re-defining exacerbations of chronic obstructive pulmonary disease and developing tools to characterise heterogeneity and treatment response: Re-defining exacerbations of chronic obstructive pulmonary disease and developing tools to characterise heterogeneity and treatment response

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Progressive in nature, COPD is punctuated by acute periods of worsening termed ‘exacerbations’, a cause of morbidity and mortality. Exacerbations are heterogenous with respect to symptoms and inflammatory biology. In this thesis, mathematical methods were researched for their appropriateness to characterise COPD heterogeneity and predict treatment response. Algorithms were developed to predict treatment outcome for a cohort of hospitalised patients with airways disease exacerbations. In a second patient cohort, cluster analysis was performed on longitudinal measurements at 'stable state’ and ‘exacerbation’ in order to define objective ‘states’ of COPD based on symptoms and inflammatory biology. Objective states included a low overall symptom burden state and crisis states with elevated symptoms with or without particular inflammation. Objective states were compared to conventional ‘stable state’ and ‘exacerbation’ definitions and found to better correspond to distinct patterns of symptoms and inflammation. Algorithms were trained and tested to identify to which objective state any given measurement of symptoms and inflammation from a patient belongs at a given point in time. Different treatment response trajectories or ‘trajectotypes’ of symptoms and inflammation were characterised for crisis states between the time of treatment and follow-up measurements. Trajectotypes included symptom resolution with or without different patterns of inflammatory resolution, as well as a trajectotype of no change between treatment and follow-up. Individualised symptom shape profile trajectories post-treatment were found from daily time series of self-reported symptom scores. This thesis provides a new definition of COPD states as an alternative to ‘stable state’ and ‘exacerbation’ definitions. Together with the characterisation of distinct treatment response trajectories based on symptom and inflammatory resolution, the findings of this thesis set the stage for future clinical studies evaluating enhanced personalisation of treatment allocation and monitoring for patients with COPD