Space Station Spartan study

The required extension, enhancement, and upgrading of the present Spartan concept are described to conduct operations from the space station using the station's unique facilities and operational features. The space station Spartan (3S), the free flyer will be deployed from and returned to the space station and will conduct scientific missions of much longer duration than possible with the current Spartan. The potential benefits of a space station Spartan are enumerated. The objectives of the study are: (1) to develop a credible concept for a space station Spartan; and (2) to determine the associated requirements and interfaces with the space station to help ensure that the 3S can be properly accommodated

Biological evolution through mutation, selection, and drift: An introductory review

Motivated by present activities in (statistical) physics directed towards biological evolution, we review the interplay of three evolutionary forces: mutation, selection, and genetic drift. The review addresses itself to physicists and intends to bridge the gap between the biological and the physical literature. We first clarify the terminology and recapitulate the basic models of population genetics, which describe the evolution of the composition of a population under the joint action of the various evolutionary forces. Building on these foundations, we specify the ingredients explicitly, namely, the various mutation models and fitness landscapes. We then review recent developments concerning models of mutational degradation. These predict upper limits for the mutation rate above which mutation can no longer be controlled by selection, the most important phenomena being error thresholds, Muller's ratchet, and mutational meltdowns. Error thresholds are deterministic phenomena, whereas Muller's ratchet requires the stochastic component brought about by finite population size. Mutational meltdowns additionally rely on an explicit model of population dynamics, and describe the extinction of populations. Special emphasis is put on the mutual relationship between these phenomena. Finally, a few connections with the process of molecular evolution are established.Comment: 62 pages, 6 figures, many reference

Intracellular transport driven by cytoskeletal motors: General mechanisms and defects

Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large. The cytoskeleton, composed of three types of filaments, determines the shape of the cell and plays a role in cell motion. It also serves as a road network for the so-called cytoskeletal motors. These molecules can attach to a cytoskeletal filament, perform directed motion, possibly carrying along some cargo, and then detach. It is a central issue to understand how intracellular transport driven by molecular motors is regulated, in particular because its breakdown is one of the signatures of some neuronal diseases like the Alzheimer. We give a survey of the current knowledge on microtubule based intracellular transport. We first review some biological facts obtained from experiments, and present some modeling attempts based on cellular automata. We start with background knowledge on the original and variants of the TASEP (Totally Asymmetric Simple Exclusion Process), before turning to more application oriented models. After addressing microtubule based transport in general, with a focus on in vitro experiments, and on cooperative effects in the transportation of large cargos by multiple motors, we concentrate on axonal transport, because of its relevance for neuronal diseases. It is a challenge to understand how this transport is organized, given that it takes place in a confined environment and that several types of motors moving in opposite directions are involved. We review several features that could contribute to the efficiency of this transport, including the role of motor-motor interactions and of the dynamics of the underlying microtubule network. Finally, we discuss some still open questions.Comment: 74 pages, 43 figure

LLV - Lunar Logistics Vehicle Final report

Design of unmanned space vehicle for landing 2500 pound payload on moo

A survey of machine learning techniques applied to self organizing cellular networks

In this paper, a survey of the literature of the past fifteen years involving Machine Learning (ML) algorithms applied to self organizing cellular networks is performed. In order for future networks to overcome the current limitations and address the issues of current cellular systems, it is clear that more intelligence needs to be deployed, so that a fully autonomous and flexible network can be enabled. This paper focuses on the learning perspective of Self Organizing Networks (SON) solutions and provides, not only an overview of the most common ML techniques encountered in cellular networks, but also manages to classify each paper in terms of its learning solution, while also giving some examples. The authors also classify each paper in terms of its self-organizing use-case and discuss how each proposed solution performed. In addition, a comparison between the most commonly found ML algorithms in terms of certain SON metrics is performed and general guidelines on when to choose each ML algorithm for each SON function are proposed. Lastly, this work also provides future research directions and new paradigms that the use of more robust and intelligent algorithms, together with data gathered by operators, can bring to the cellular networks domain and fully enable the concept of SON in the near future

A study of concept options for the evolution of Space Station Freedom

Two conceptual evolution configurations for Space Station Freedom, a research and development configuration, and a transportation node configuration are described and analyzed. Results of pertinent analyses of mass properties, attitude control, microgravity, orbit lifetime, and reboost requirements are provided along with a description of these analyses. Also provided are brief descriptions of the elements and systems that comprise these conceptual configurations

DEVELOPMENT OF INSTRUMENTATION AND CONTROL SYSTEMS FOR AN INTEGRAL LARGE SCALE PRESSURIZED WATER REACTOR

Small and large scale integral light water reactors are being developed to supply electrical power and to meet the needs of process heat, primarily for water desalination. This dissertation research focuses on the instrumentation and control of a large integral inherently safe light water reactor (designated as I2S-LWR) which is being designed as part of a grant by the U.S. Department of Energy Integrated Research Project (IRP). This 969 MWe integral pressurized water reactor (PWR) incorporates as many passive safety features as possible while maintaining competitive costs with current light water reactors. In support of this work, the University of Tennessee has been engaged in research to solve the instrumentation and control challenges posed by such a reactor design. This dissertation is a contribution to this effort. The objectives of this dissertation are to establish the feasibility and conceptual development of instrumentation strategies and control approaches for the I2S-LWR, with consideration to the state of the art of the field. The objectives of this work are accomplished by the completion of the following tasks: Assessment of instrumentation needs and technology gaps associated with the instrumentation of the I2S-LWR for process monitoring and control purposes. Development of dynamic models of a large integral PWR core, micro-channel heat exchangers (MCHX) that are contained within the reactor pressure vessel, and steam flashing drums located external to the containment building. Development and demonstration of control strategies for reactor power regulation, steam flashing drum pressure regulation, and flashing drum water level regulation for steady state and load-following conditions. Simulation, detection, and diagnosis of process anomalies in the I2S-LWR model. This dissertation is innovative and significant in that it reports the first instrumentation and control study of nuclear steam supply by integral pressurized water reactor coupled to an isenthalpic expansion vessel for steam generation. Further, this dissertation addresses the instrumentation and control challenges associated with integral reactors, as well as improvements to inherent safety possible in the instrumentation and control design of integral reactors. The results of analysis and simulation demonstrate the successful development of dynamic modeling, control strategies, and instrumentation for a large integral PWR