Assessing the Effectiveness of Direct Data Merging Strategy in Long-Term and Large-Scale Pharmacometabonomics

Because of the extended period of clinic data collection and huge size of analyzed samples, the long-term and large-scale pharmacometabonomics profiling is frequently encountered in the discovery of drug/target and the guidance of personalized medicine. So far, integration of the results (ReIn) from multiple experiments in a large-scale metabolomic profiling has become a widely used strategy for enhancing the reliability and robustness of analytical results, and the strategy of direct data merging (DiMe) among experiments is also proposed to increase statistical power, reduce experimental bias, enhance reproducibility and improve overall biological understanding. However, compared with the ReIn, the DiMe has not yet been widely adopted in current metabolomics studies, due to the difficulty in removing unwanted variations and the inexistence of prior knowledges on the performance of the available merging methods. It is therefore urgently needed to clarify whether DiMe can enhance the performance of metabolic profiling or not. Herein, the performance of DiMe on 4 pairs of benchmark datasets was comprehensively assessed by multiple criteria (classification capacity, robustness and false discovery rate). As a result, integration/merging-based strategies (ReIn and DiMe) were found to perform better under all criteria than those strategies based on single experiment. Moreover, DiMe was discovered to outperform ReIn in classification capacity and robustness, while the ReIn showed superior capacity in controlling false discovery rate. In conclusion, these findings provided valuable guidance to the selection of suitable analytical strategy for current metabolomics

Hidden Strains: Understanding Schizophrenia's Impact on Families and Communities

"Hidden Strains: Understanding Schizophrenia's Impact on Families and Communities" examines the challenges family caregivers of schizophrenia patients face in Romania. This study uncovers the socio-economic burdens and limited psychiatric support, particularly in rural areas, compounded by societal stigma. A significant finding is the caregivers' knowledge gap about schizophrenia, underscoring the need for mental health education for early detection and stigma reduction. The research stresses the vital roles of family and community in schizophrenia care, advocating for more community resources. It introduces innovative care models like the "Open Dialogue Approach" from Scandinavia, suggesting solutions for Romania's mental health challenges. Broadening its view, "Hidden Strains" contrasts Romanian mental health issues with global trends, emphasizing the urgency of mental health reforms. Concluding with recommendations for worldwide application, this work offers insights for professionals, caregivers, and policymakers, and resonates universally despite its Romanian foundation

Essential Notes in Psychiatry

Psychiatry is one of the major specialties of medicine, and is concerned with the study and treatment of mental disorders. In recent times the field is growing with the discovery of effective therapies and interventions that alleviate suffering in people with mental disorders. This book of psychiatry is concise and clearly written so that it is usable for doctors in training, students and clinicians dealing with psychiatric illness in everyday practice. The book is a primer for those beginning to learn about emotional disorders and psychosocial consequences of severe physical and psychological trauma; and violence. Emphasis is placed on effective therapies and interventions for selected conditions such as dementia and suicide among others and the consequences of stress in the workplace. The book also highlights important causes of mental disorders in children

Eye quietness and quiet eye in expert and novice golf performance: an electrooculographic analysis

Quiet eye (QE) is the final ocular fixation on the target of an action (e.g., the ball in golf putting). Camerabased eye-tracking studies have consistently found longer QE durations in experts than novices; however, mechanisms underlying QE are not known. To offer a new perspective we examined the feasibility of measuring the QE using electrooculography (EOG) and developed an index to assess ocular activity across time: eye quietness (EQ). Ten expert and ten novice golfers putted 60 balls to a 2.4 m distant hole. Horizontal EOG (2ms resolution) was recorded from two electrodes placed on the outer sides of the eyes. QE duration was measured using a EOG voltage threshold and comprised the sum of the pre-movement and post-movement initiation components. EQ was computed as the standard deviation of the EOG in 0.5 s bins from –4 to +2 s, relative to backswing initiation: lower values indicate less movement of the eyes, hence greater quietness. Finally, we measured club-ball address and swing durations. T-tests showed that total QE did not differ between groups (p = .31); however, experts had marginally shorter pre-movement QE (p = .08) and longer post-movement QE (p < .001) than novices. A group × time ANOVA revealed that experts had less EQ before backswing initiation and greater EQ after backswing initiation (p = .002). QE durations were inversely correlated with EQ from –1.5 to 1 s (rs = –.48 - –.90, ps = .03 - .001). Experts had longer swing durations than novices (p = .01) and, importantly, swing durations correlated positively with post-movement QE (r = .52, p = .02) and negatively with EQ from 0.5 to 1s (r = –.63, p = .003). This study demonstrates the feasibility of measuring ocular activity using EOG and validates EQ as an index of ocular activity. Its findings challenge the dominant perspective on QE and provide new evidence that expert-novice differences in ocular activity may reflect differences in the kinematics of how experts and novices execute skills

Contemporary Perspectives on Ageism

Older adults outnumbering children; Gerontology/geriatrics; Aging world population; The study of ageism; Ageism is the most prevalent form of discriminatio

Organisational self-renewal : process design

Firms compete based on their relative ability to renew as much as they do on their ability to extract profits from product-markets. Drawing from literature and case studies the research explores how renewal is affected in organisations. The main dynamics of the renewal process, and the issues and skills involved in its management, therefore, receive detailed treatment. Relevant data is gathered from a variety of primary and secondary sources. The research begins with an effort to understand the forces that trigger and processes that act to sustain decline in organisations. These findings are contrasted with a number of case studies that serve the identification of underlying characteristics and dynamics common to successful organizations. This comparison serves to uncover principles of successful organisation and that hold the key to renewal and sustained growth. The main objective of this research is to increase the understanding and awareness of the processes, problems and successful means of organisational renewal. Underlying is the concern to develop more formalised models and translate these findings into a useful conceptual framework as a basis and stimulus for further research and as a helpful guideline for management practitioners to handle successfully the problems of entropy and organisational ossification of their business

An aesthetic for sustainable interactions in product-service systems?

Copyright @ 2012 Greenleaf PublishingEco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability. However the application of this concept is still very limited because its implementation and diffusion is hindered by several barriers (cultural, corporate and regulative ones). The paper investigates the barriers that affect the attractiveness and acceptation of eco-efficient PSS alternatives, and opens the debate on the aesthetic of eco-efficient PSS, and the way in which aesthetic could enhance some specific inner qualities of this kinds of innovations. Integrating insights from semiotics, the paper outlines some first research hypothesis on how the aesthetic elements of an eco-efficient PSS could facilitate user attraction, acceptation and satisfaction

Armed robbery in the southeastern states of contemporary Nigeria: a criminological analys

The calls for the study of criminal actions in different societies as a consequent of the rapid socio-culture, political, and economic changes blowing over these societies is not new in criminology texts (Clifford 1965; Bennett 1980; Brown, Esbensen and Geis 1991). This study building directly on key insights about armed robbery in contemporary Nigeria: patterns, rates, modus operandi, and social organisation (characteristics), begins by noting the importance of these calls, and the need for conceptual revival in this regard. Conscientious approach directed at developing a brand of theoretical framework that approximates the criminal behaviour in question and context is one sure way of achieving this revival. This research draws 86 samples of armed robbers in three selected prisons and states of contemporary Nigeria to provide first and foremost, a fuller criminological and sociological descriptive analysis of the offence and the offenders. Analyses of data provide findings from which wide scales of meanings are possible. For instances, results suggest that offenders are more likely to be those at the economic margin of the society; those with a taste of western education–largely educated or quasi-educated as a way of life; those expressing their despise to a system they perceived to be corrupt and highly elitist. They are likely to be armed with weapons; be in groups; and have females as members of the gang/group. They are also and fundamentally, likely to tap other peculiarities of Nigerian society such as the belief in "African insurance" (charms), and pervasive corruption. Results of test show that there tends to be good degrees of causal relationships between the sources of learning about modern armed robbery and the frequency of committing the offence, planning, and the modus operandi. Within the broad context of sociological theory, and more specifically, the Tarde's imitation, Sutherland's differential association, and Iwarmie-Jaja's previous experience strands, the results of the empirical investigation are synthesised and explained. The research draws upon these conceptual threads to suggest a better and fuller model of armed robbery in contemporary armed robbery. This alternative model of explanation is described and referred to as "emulation".Criminology and Security ScienceDLITT ET PHIL (CRIMINOLOGY