17 research outputs found
A quantitative and qualitative analysis of Positron Emission Tomography (PET) in Yttrium-90 radioembolization; investigating the utility of PET dosimetry in identifying sites of necrosis and viable tumor
Purpose: PET imaging is becoming more common for verifying the location of 90Y microspheres during liver cancer treatment. The work aims to predict which patients will likely to have remaining viable tumors based on the 90Y PET image taken right after the radioembolization.
Methods: 10 hepatocellular carcinoma (HCC) patients treated by radioembolization with 90Y glass microspheres were included in this study. Post-treatment PET was coregistered with the follow-up image to investigate the correlation between the isodose contours based on the post-treatment PET image and the necrosis and viable tumor on the follow-up image. To evaluate the similarity quantitatively, isodose contours derived from 90Y PET and necrosis area on the follow-up image were compared using the Dice similarity coefficient. In addition to the quantitative assessment, a qualitative assessment of a 1โ5-point scale was utilized to rate the correlation of underdose regions on the post-treatment PET and the viable tumor on the follow-up. The study thereby provided insights into the interpretation and analysis of post-radioembolization imaging in HCC patients.
Results: The findings in this retrospective study with 10 patients included for quantitative assessment suggest an isodose range of 250 Gy to 300 Gy yields the best match for the necrosis site. Also, the qualitative assessment of these 10 patients shows a median agreement of 4 on a 1โ5-point scale.
Conclusion: 90Y PET/CT evaluation and dosimetry add clinical benefit to patient treatments by locating untreated tumors and potential sites of recurrence
Diseases of the Abdomen and Pelvis 2018-2021: Diagnostic Imaging - IDKD Book
Gastrointestinal disease; PET/CT; Radiology; X-ray; IDKD; Davo
Ultrasound Imaging
This book provides an overview of ultrafast ultrasound imaging, 3D high-quality ultrasonic imaging, correction of phase aberrations in medical ultrasound images, etc. Several interesting medical and clinical applications areas are also discussed in the book, like the use of three dimensional ultrasound imaging in evaluation of Asherman's syndrome, the role of 3D ultrasound in assessment of endometrial receptivity and follicular vascularity to predict the quality oocyte, ultrasound imaging in vascular diseases and the fetal palate, clinical application of ultrasound molecular imaging, Doppler abdominal ultrasound in small animals and so on
Hepatic Surgery
Longmire, called it a "hostile" organ because it welcomes malignant cells and sepsis so warmly, bleeds so copiously, and is often the ?rst organ to be injured in blunt abdominal trauma. To balance these negative factors, the liver has two great attributes: its ability to regenerate after massive loss of substance, and its ability, in many cases, to forgive insult. This book covers a wide spectrum of topics including, history of liver surgery, surgical anatomy of the liver, techniques of liver resection, benign and malignant liver tumors, portal hypertension, and liver trauma. Some important topics were covered in more than one chapter like liver trauma, portal hypertension and pediatric liver tumors
Advancements in minimally invasive image-guided liver therapies
This thesis is a
contribution to the fight against cancer. It focuses on patients with hepatic
malignancies.
Interventional oncology (IO) is a rapidly evolving sub-speciality of
interventional radiology with an increasing role in the management of cancer
patients. Over the past two decades interventional radiologists together with
scientists have ridding the tidal wave of technological innovation to introduce
multiple novel cancer treatments. IO procedures are minimally invasive,
targeted therapies that are associated with low complication rates and short
hospital admissions. Such therapies offer clear advantages over surgical
procedures and intense chemotherapeutic regimes that put a larger burden on
both the health care budget and patients.
In this thesis several novel minimally invasive therapies are investigated.
PART I focuses on image-guided percutaneous RFA. PART II discusses
transarterial liver therapies, such as transarterial chemoembolisation,
radioembolisation and percutaneous hepatic perfusion. PART III investigates
ways to improve the management of patients that undergo IO procedures.LUMC / Geneeskund
Characterization of alar ligament on 3.0T MRI: a cross-sectional study in IIUM Medical Centre, Kuantan
INTRODUCTION: The main purpose of the study is to compare the normal anatomy of alar
ligament on MRI between male and female. The specific objectives are to assess the prevalence
of alar ligament visualized on MRI, to describe its characteristics in term of its course, shape and
signal homogeneity and to find differences in alar ligament signal intensity between male and
female. This study also aims to determine the association between the heights of respondents
with alar ligament signal intensity and dimensions.
MATERIALS & METHODS: 50 healthy volunteers were studied on 3.0T MR scanner
Siemens Magnetom Spectra using 2-mm proton density, T2 and fat-suppression sequences. Alar
ligament is depicted in 3 planes and the visualization and variability of the ligament courses,
shapes and signal intensity characteristics were determined. The alar ligament dimensions were
also measured.
RESULTS: Alar ligament was best depicted in coronal plane, followed by sagittal and axial
planes. The orientations were laterally ascending in most of the subjects (60%), predominantly
oval in shaped (54%) and 67% showed inhomogenous signal. No significant difference of alar
ligament signal intensity between male and female respondents. No significant association was
found between the heights of the respondents with alar ligament signal intensity and dimensions.
CONCLUSION: Employing a 3.0T MR scanner, the alar ligament is best portrayed on coronal
plane, followed by sagittal and axial planes. However, tremendous variability of alar ligament as
depicted in our data shows that caution needs to be exercised when evaluating alar ligament,
especially during circumstances of injury
Case series of breast fillers and how things may go wrong: radiology point of view
INTRODUCTION: Breast augmentation is a procedure opted by women to overcome sagging
breast due to breastfeeding or aging as well as small breast size. Recent years have shown the
emergence of a variety of injectable materials on market as breast fillers. These injectable
breast fillers have swiftly gained popularity among women, considering the minimal
invasiveness of the procedure, nullifying the need for terrifying surgery. Little do they know
that the procedure may pose detrimental complications, while visualization of breast
parenchyma infiltrated by these fillers is also deemed substandard; posing diagnostic
challenges. We present a case series of three patients with prior history of hyaluronic acid and
collagen breast injections.
REPORT: The first patient is a 37-year-old lady who presented to casualty with worsening
shortness of breath, non-productive cough, central chest pain; associated with fever and chills
for 2-weeks duration. The second patient is a 34-year-old lady who complained of cough, fever
and haemoptysis; associated with shortness of breath for 1-week duration. CT in these cases
revealed non thrombotic wedge-shaped peripheral air-space densities.
The third patient is a 37โyearโold female with right breast pain, swelling and redness for 2-
weeks duration. Previous collagen breast injection performed 1 year ago had impeded
sonographic visualization of the breast parenchyma. MRI breasts showed multiple non-
enhancing round and oval shaped lesions exhibiting fat intensity.
CONCLUSION: Radiologists should be familiar with the potential risks and hazards as well
as limitations of imaging posed by breast fillers such that MRI is required as problem-solving
tool