Immunization of networks with community structure

In this study, an efficient method to immunize modular networks (i.e., networks with community structure) is proposed. The immunization of networks aims at fragmenting networks into small parts with a small number of removed nodes. Its applications include prevention of epidemic spreading, intentional attacks on networks, and conservation of ecosystems. Although preferential immunization of hubs is efficient, good immunization strategies for modular networks have not been established. On the basis of an immunization strategy based on the eigenvector centrality, we develop an analytical framework for immunizing modular networks. To this end, we quantify the contribution of each node to the connectivity in a coarse-grained network among modules. We verify the effectiveness of the proposed method by applying it to model and real networks with modular structure.Comment: 3 figures, 1 tabl

The failure tolerance of mechatronic software systems to random and targeted attacks

This paper describes a complex networks approach to study the failure tolerance of mechatronic software systems under various types of hardware and/or software failures. We produce synthetic system architectures based on evidence of modular and hierarchical modular product architectures and known motifs for the interconnection of physical components to software. The system architectures are then subject to various forms of attack. The attacks simulate failure of critical hardware or software. Four types of attack are investigated: degree centrality, betweenness centrality, closeness centrality and random attack. Failure tolerance of the system is measured by a 'robustness coefficient', a topological 'size' metric of the connectedness of the attacked network. We find that the betweenness centrality attack results in the most significant reduction in the robustness coefficient, confirming betweenness centrality, rather than the number of connections (i.e. degree), as the most conservative metric of component importance. A counter-intuitive finding is that "designed" system architectures, including a bus, ring, and star architecture, are not significantly more failure-tolerant than interconnections with no prescribed architecture, that is, a random architecture. Our research provides a data-driven approach to engineer the architecture of mechatronic software systems for failure tolerance.Comment: Proceedings of the 2013 ASME International Design Engineering Technical Conferences & Computers and Information in Engineering Conference IDETC/CIE 2013 August 4-7, 2013, Portland, Oregon, USA (In Print

Modular design of data-parallel graph algorithms

Amorphous Data Parallelism has proven to be a suitable vehicle for implementing concurrent graph algorithms effectively on multi-core architectures. In view of the growing complexity of graph algorithms for information analysis, there is a need to facilitate modular design techniques in the context of Amorphous Data Parallelism. In this paper, we investigate what it takes to formulate algorithms possessing Amorphous Data Parallelism in a modular fashion enabling a large degree of code re-use. Using the betweenness centrality algorithm, a widely popular algorithm in the analysis of social networks, we demonstrate that a single optimisation technique can suffice to enable a modular programming style without loosing the efficiency of a tailor-made monolithic implementation

ModuLand plug-in for Cytoscape: determination of hierarchical layers of overlapping network modules and community centrality

Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent modules of the lower layer. The tool assigns module cores, which predict the function of the whole module, and determines key nodes bridging two or multiple modules. The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux, or Mac OS. We demonstrate its use on protein structure and metabolic networks. Availability: The plug-in and its user guide can be downloaded freely from: http://www.linkgroup.hu/modules.php. Contact: [email protected] Supplementary information: Supplementary information is available at Bioinformatics online.Comment: 39 pages, 1 figure and a Supplement with 9 figures and 10 table

Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases

Cellular networks undergo rearrangements during stress and diseases. In un-stressed state the yeast protein-protein interaction network (interactome) is highly compact, and the centrally organized modules have a large overlap. During stress several original modules became more separated, and a number of novel modules also appear. A few basic functions, such as the proteasome preserve their central position. However, several functions with high energy demand, such the cell-cycle regulation loose their original centrality during stress. A number of key stress-dependent protein complexes, such as the disaggregation-specific chaperone, Hsp104, gain centrality in the stressed yeast interactome. Molecular chaperones, heat shock, or stress proteins form complex interaction networks (the chaperome) with each other and their partners. Here we show that the human chaperome recovers the segregation of protein synthesis-coupled and stress-related chaperones observed in yeast recently. Examination of yeast and human interactomes shows that (1) chaperones are inter-modular integrators of protein-protein interaction networks, which (2) often bridge hubs and (3) are favorite candidates for extensive phosphorylation. Moreover, chaperones (4) become more central in the organization of the isolated modules of the stressed yeast protein-protein interaction network, which highlights their importance in the de-coupling and re-coupling of network modules during and after stress. Chaperone-mediated evolvability of cellular networks may play a key role in cellular adaptation during stress and various polygenic and chronic diseases, such as cancer, diabetes or neurodegeneration.Comment: 13 pages, 3 figures, 1 glossar