Lost in optimisation of water distribution systems? A literature review of system design

This is the final version of the article. Available from MDPI via the DOI in this record.Optimisation of water distribution system design is a well-established research field, which has been extremely productive since the end of the 1980s. Its primary focus is to minimise the cost of a proposed pipe network infrastructure. This paper reviews in a systematic manner articles published over the past three decades, which are relevant to the design of new water distribution systems, and the strengthening, expansion and rehabilitation of existing water distribution systems, inclusive of design timing, parameter uncertainty, water quality, and operational considerations. It identifies trends and limits in the field, and provides future research directions. Exclusively, this review paper also contains comprehensive information from over one hundred and twenty publications in a tabular form, including optimisation model formulations, solution methodologies used, and other important details

The evolution of cell formation problem methodologies based on recent studies (1997-2008): review and directions for future research

This paper presents a literature review of the cell formation (CF) problem concentrating on formulations proposed in the last decade. It refers to a number of solution approaches that have been employed for CF such as mathematical programming, heuristic and metaheuristic methodologies and artificial intelligence strategies. A comparison and evaluation of all methodologies is attempted and some shortcomings are highlighted. Finally, suggestions for future research are proposed useful for CF researchers

How enzyme economy shapes metabolic fluxes

Metabolic fluxes are governed by physical and economic principles. Stationarity constrains them to a subspace in flux space and thermodynamics makes them lead from higher to lower chemical potentials. At the same time, fluxes in cells represent a compromise between metabolic performance and enzyme cost. To capture this, some flux prediction methods penalise larger fluxes by heuristic cost terms. Economic flux analysis, in contrast, postulates a balance between enzyme costs and metabolic benefits as a necessary condition for fluxes to be realised by kinetic models with optimal enzyme levels. The constraints are formulated using economic potentials, state variables that capture the enzyme labour embodied in metabolites. Generally, fluxes must lead from lower to higher economic potentials. This principle, which resembles thermodynamic constraints, can complement stationarity and thermodynamic constraints in flux analysis. Futile modes, which would be incompatible with economic potentials, are defined algebraically and can be systematically removed from flux distributions. Enzymes that participate in potential futile modes are likely targets of regulation. Economic flux analysis can predict high-yield and low-yield strategies, and captures preemptive expression, multi-objective optimisation, and flux distributions across several cells living in symbiosis. Inspired by labour value theories in economics, it justifies and extends the principle of minimal fluxes and provides an intuitive framework to model the complex interplay of fluxes, metabolic control, and enzyme costs in cells

Scheduling With Alternatives Machine Using Fuzzy Inference System And Genetic Algorithm.

As the manufacturing activities in today's industries are getting more and more complex, it is required for the manufacturing company to have a good shop floor production scheduling to plan and schedule their production orders. Industri pengeluarcim kini telah berkembang pesat dan aktiviti pengeluarannya semakin kompleks, dengan itu syarikat pengeluar memerlukan jadual lantai pengeluaran (shop floor) yang terbaik untuk merancang permintaan pengeluaran (product)

Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast

Every protein has a biosynthetic cost to the cell based on the synthesis of its constituent amino acids. In order to optimise growth and reproduction, natural selection is expected, where possible, to favour the use of proteins whose constituents are cheaper to produce, as reduced biosynthetic cost may confer a fitness advantage to the organism. Quantifying the cost of amino acid biosynthesis presents challenges, since energetic requirements may change across different cellular and environmental conditions. We developed a systems biology approach to estimate the cost of amino acid synthesis based on genome-scale metabolic models and investigated the effects of the cost of amino acid synthesis on Saccharomyces cerevisiae gene expression and protein evolution. First, we used our two new and six previously reported measures of amino acid cost in conjunction with codon usage bias, tRNA gene number and atomic composition to identify which of these factors best predict transcript and protein levels. Second, we compared amino acid cost with rates of amino acid substitution across four species in the genus Saccharomyces. Regardless of which cost measure is used, amino acid biosynthetic cost is weakly associated with transcript and protein levels. In contrast, we find that biosynthetic cost and amino acid substitution rates show a negative correlation, but for only a subset of cost measures. In the economy of the yeast cell, we find that the cost of amino acid synthesis plays a limited role in shaping transcript and protein expression levels compared to that of translational optimisation. Biosynthetic cost does, however, appear to affect rates of amino acid evolution in Saccharomyces, suggesting that expensive amino acids may only be used when they have specific structural or functional roles in protein sequences. However, as there appears to be no single currency to compute the cost of amino acid synthesis across all cellular and environmental conditions, we conclude that a systems approach is necessary to unravel the full effects of amino acid biosynthetic cost in complex biological systems

Spatially optimised sustainable urban development

PhD ThesisTackling urbanisation and climate change requires more sustainable and resilient cities, which in turn will require planners to develop a portfolio of measures to manage climate risks such as flooding, meet energy and greenhouse gas reduction targets, and prioritise development on brownfield sites to preserve greenspace. However, the policies, strategies and measures put in place to meet such objectives can frequently conflict with each other or deliver unintended consequences, hampering long-term sustainability. For example, the densification of cities in order to reduce transport energy use can increase urban heat island effects and surface water flooding from extreme rainfall events. In order to make coherent decisions in the presence of such complex multi-dimensional spatial conflicts, urban planners require sophisticated planning tools to identify and manage potential trade-offs between the spatial strategies necessary to deliver sustainability. To achieve this aim, this research has developed a multi-objective spatial optimisation framework for the spatial planning of new residential development within cities. The implemented framework develops spatial strategies of required new residential development that minimize conflicts between multiple sustainability objectives as a result of planning policy and climate change related hazards. Five key sustainability objectives have been investigated, namely; (i) minimizing risk from heat waves, (ii) minimizing the risk from flood events, (iii) minimizing travel costs in order to reduce transport emissions, (iv) minimizing urban sprawl and (v) preventing development on existing greenspace. A review identified two optimisation algorithms as suitable for this task. Simulated Annealing (SA) is a traditional optimisation algorithm that uses a probabilistic approach to seek out a global optima by iteratively assessing a wide range of spatial configurations against the objectives under consideration. Gradual ‘cooling’, or reducing the probability of jumping to a different region of the objective space, helps the SA to converge on globally optimal spatial patterns. Genetic Algorithms (GA) evolve successive generations of solutions, by both recombining attributes and randomly mutating previous generations of solutions, to search for and converge towards superior spatial strategies. The framework works towards, and outputs, a series of Pareto-optimal spatial plans that outperform all other plans in at least one objective. This approach allows for a range of best trade-off plans for planners to choose from. ii Both SA and GA were evaluated for an initial case study in Middlesbrough, in the North East of England, and were able to identify strategies which significantly improve upon the local authority’s development plan. For example, the GA approach is able to identify a spatial strategy that reduces the travel to work distance between new development and the central business district by 77.5% whilst nullifying the flood risk to the new development. A comparison of the two optimisation approaches for the Middlesbrough case study revealed that the GA is the more effective approach. The GA is more able to escape local optima and on average outperforms the SA by 56% in in the Pareto fronts discovered whilst discovering double the number of multi-objective Pareto-optimal spatial plans. On the basis of the initial Middlesbrough case study the GA approach was applied to the significantly larger, and more computationally complex, problem of optimising spatial development plans for London in the UK – a total area of 1,572km2. The framework identified optimal strategies in less than 400 generations. The analysis showed, for example, strategies that provide the lowest heat risk (compared to the feasible spatial plans found) can be achieved whilst also using 85% brownfield land to locate new development. The framework was further extended to investigate the impact of different development and density regulations. This enabled the identification of optimised strategies, albeit at lower building density, that completely prevent any increase in urban sprawl whilst also improving the heat risk objective by 60% against a business as usual development strategy. Conversely by restricting development to brownfield the ability of the spatial plan to optimise future heat risk is reduced by 55.6% against the business as usual development strategy. The results of both case studies demonstrate the potential of spatial optimisation to provide planners with optimal spatial plans in the presence of conflicting sustainability objectives. The resulting diagnostic information provides an analytical appreciation of the sensitivity between conflicts and therefore the overall robustness of a plan to uncertainty. With the inclusion of further objectives, and qualitative information unsuitable for this type of analysis, spatial optimization can constitute a powerful decision support tool to help planners to identify spatial development strategies that satisfy multiple sustainability objectives and provide an evidence base for better decision making

Feasibility analysis of using special purpose machines for drilling-related operations

This work focuses on special purpose machine tools (SPMs), providing a modular platform for performing drilling-related operations. One of the main challenges in using SPMs is selecting the most appropriate machine tool among many alternatives. This thesis introduces a feasibility analysis procedure developed to support decision-making through the assessment of the strengths and limitations of SPMs. To achieve this, technical and economic feasibility analyses, a sensitivity analysis, and an optimisation model were developed and a case study was provided for each analysis. The results indicated that although technical feasibility analysis leads decision-makers to select a feasible machine tool, complementary analyses are required for making an informed decision and improving profitability. Accordingly, a mathematical cost model was developed to perform economic and sensitivity analyses and investigate the profitability of any selected SPM configuration. In addition, an optimisation procedure was applied to the cost model in order to investigate the effect of process parameters and the SPM configuration on the decision-making. Finally, the developed analyses were then integrated into a model in a proper sequence that can evaluate whether the SPM is appropriate for producing the given part and achieving higher productivity. To validate this integrated model three different case studies were presented and results were discussed. The results showed that the developed model is a very useful tool in assisting manufacturers to evaluate the performance of SPMs in comparison with other alternatives considered from different perspectives