1,755 research outputs found
Proceedings of the 2021 Joint Workshop of Fraunhofer IOSB and Institute for Anthropomatics, Vision and Fusion Laboratory
2021, the annual joint workshop of the Fraunhofer IOSB and KIT IES was hosted at the IOSB in Karlsruhe. For a week from the 2nd to the 6th July the doctoral students extensive reports on the status of their research. The results and ideas presented at the workshop are collected in this book in the form of detailed technical reports
Proceedings of the 2021 Joint Workshop of Fraunhofer IOSB and Institute for Anthropomatics, Vision and Fusion Laboratory
2021, the annual joint workshop of the Fraunhofer IOSB and KIT IES was hosted at the IOSB in Karlsruhe. For a week from the 2nd to the 6th July the doctoral students extensive reports on the status of their research. The results and ideas presented at the workshop are collected in this book in the form of detailed technical reports
Artificial intelligence (AI) in rare diseases: is the future brighter?
The amount of data collected and managed in (bio)medicine is ever-increasing. Thus, there is a need to rapidly and efficiently collect, analyze, and characterize all this information. Artificial intelligence (AI), with an emphasis on deep learning, holds great promise in this area and is already being successfully applied to basic research, diagnosis, drug discovery, and clinical trials. Rare diseases (RDs), which are severely underrepresented in basic and clinical research, can particularly benefit from AI technologies. Of the more than 7000 RDs described worldwide, only 5% have a treatment. The ability of AI technologies to integrate and analyze data from different sources (e.g., multi-omics, patient registries, and so on) can be used to overcome RDs' challenges (e.g., low diagnostic rates, reduced number of patients, geographical dispersion, and so on). Ultimately, RDs' AI-mediated knowledge could significantly boost therapy development. Presently, there are AI approaches being used in RDs and this review aims to collect and summarize these advances. A section dedicated to congenital disorders of glycosylation (CDG), a particular group of orphan RDs that can serve as a potential study model for other common diseases and RDs, has also been included.info:eu-repo/semantics/publishedVersio
Non-Imaging Medical Data Synthesis for Trustworthy AI: A Comprehensive Survey
Data quality is the key factor for the development of trustworthy AI in
healthcare. A large volume of curated datasets with controlled confounding
factors can help improve the accuracy, robustness and privacy of downstream AI
algorithms. However, access to good quality datasets is limited by the
technical difficulty of data acquisition and large-scale sharing of healthcare
data is hindered by strict ethical restrictions. Data synthesis algorithms,
which generate data with a similar distribution as real clinical data, can
serve as a potential solution to address the scarcity of good quality data
during the development of trustworthy AI. However, state-of-the-art data
synthesis algorithms, especially deep learning algorithms, focus more on
imaging data while neglecting the synthesis of non-imaging healthcare data,
including clinical measurements, medical signals and waveforms, and electronic
healthcare records (EHRs). Thus, in this paper, we will review the synthesis
algorithms, particularly for non-imaging medical data, with the aim of
providing trustworthy AI in this domain. This tutorial-styled review paper will
provide comprehensive descriptions of non-imaging medical data synthesis on
aspects including algorithms, evaluations, limitations and future research
directions.Comment: 35 pages, Submitted to ACM Computing Survey
DiscoBAX: Discovery of Optimal Intervention Sets in Genomic Experiment Design
The discovery of therapeutics to treat genetically-driven pathologies relies
on identifying genes involved in the underlying disease mechanisms. Existing
approaches search over the billions of potential interventions to maximize the
expected influence on the target phenotype. However, to reduce the risk of
failure in future stages of trials, practical experiment design aims to find a
set of interventions that maximally change a target phenotype via diverse
mechanisms. We propose DiscoBAX, a sample-efficient method for maximizing the
rate of significant discoveries per experiment while simultaneously probing for
a wide range of diverse mechanisms during a genomic experiment campaign. We
provide theoretical guarantees of approximate optimality under standard
assumptions, and conduct a comprehensive experimental evaluation covering both
synthetic as well as real-world experimental design tasks. DiscoBAX outperforms
existing state-of-the-art methods for experimental design, selecting effective
and diverse perturbations in biological systems
Confirmation and Evidence
The question how experience acts on our beliefs and how beliefs are changed in the light of experience is one of the oldest and most controversial questions in philosophy in general and epistemology in particular. Philosophy of science has replaced this question by the more specific enquiry how results of experiments act on scientific hypotheses and theories. Why do we maintain some theories while discarding others? Two general questions emerge: First, what is our reason to accept the justifying power of experience and more specifically, scientific experiments? Second, how can the relationship between theory and evidence be described and under which circumstances is a scientific theory confirmed by a piece of evidence? The book focuses on the second question, on explicating the relationship between theory and evidence and capturing the structure of a valid inductive argument. Special attention is paid to statistical applications that are prevalent in modern empirical science. After an introductory chapter about the link between confirmation and induction, the project starts with discussing qualitative accounts of confirmation in first-order predicate logic. Two major approaches, the Hempelian satisfaction criterion and the hypothetico-deductivist tradition, are contrasted to each other. This is subsequently extended to an account of the confirmation of entire theories as opposed to the confirmation of single hypothesis. Then the quantative Bayesian account of confirmation is explained and discussed on the basis of a theory of rational degrees of belief. After that, I present the various schools of statistical inference and explain the foundations of these competing schemes. Finally, I argue for a specific concept of statistical evidence, summarize the results, and sketch some open questions. </p
From classical mendelian randomization to causal networks for systematic integration of multi-omics
The number of studies with information at multiple biological levels of granularity, such as genomics, proteomics, and metabolomics, is increasing each year, and a biomedical questaion is how to systematically integrate these data to discover new biological mechanisms that have the potential to elucidate the processes of health and disease. Causal frameworks, such as Mendelian randomization (MR), provide a foundation to begin integrating data for new biological discoveries. Despite the growing number of MR applications in a wide variety of biomedical studies, there are few approaches for the systematic analysis of omic data. The large number and diverse types of molecular components involved in complex diseases interact through complex networks, and classical MR approaches targeting individual components do not consider the underlying relationships. In contrast, causal network models established in the principles of MR offer significant improvements to the classical MR framework for understanding omic data. Integration of these mostly distinct branches of statistics is a recent development, and we here review the current progress. To set the stage for causal network models, we review some recent progress in the classical MR framework. We then explain how to transition from the classical MR framework to causal networks. We discuss the identification of causal networks and evaluate the underlying assumptions. We also introduce some tests for sensitivity analysis and stability assessment of causal networks. We then review practical details to perform real data analysis and identify causal networks and highlight some of the utility of causal networks. The utilities with validated novel findings reveal the full potential of causal networks as a systems approach that will become necessary to integrate large-scale omic data
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