Charing-Cross Hospital.

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Node and Place, a study on the spatial process of railway terminus area redevelopment in central London

Bertolini and Spit (1998) have argued that any significant transport node should ideally also be a significant place in the city. However, this rarely seems to be the case, and the resolution of this disparity, which they refer to as the 'node-place' problem, in practice means redesigning what are currently regional-to-local transport nodes to also function as local pedestrian nodes. This is a complex design task, made more difficult by the fact that termini, although often located in strategic inner urban areas, are also frequently scarred by railway structures and adjacent to large wastelands or blighted neighbourhoods. Not surprisingly, there are as yet few success stories, and conversely many cases where attempts to address this problem through design have fallen below expectations. This problem, of converting railway termini and their surrounding areas into urban places, is the subject of this thesis. The argument proposes that the ‘node-place’ problem is fundamentally a spatial one. Using the methodology of space syntax, together with Hillier's compound theories of how vibrant urban places are progressively formed by the influence of the urban grid on natural movement (Hillier et al 1993 ), and the subsequent influence this has on land use patterns (Hillier 1996 ) and centre formation (Hillier 2000 ), the thesis investigates the spatial structure and functioning of eleven mainline railway terminus areas in central London. This is undertaken through a series of studies of increasing precision: historical figure-ground analyses of station areas; syntactic analysis of station contexts and the influence of the station on that context; detailed observation of movement patterns and rates in station contexts; and finally the synthesis of all data types into a single picture. On the basis of the results of these studies, it is argued that the key to the successful creation of an urban place out of a transport node is the same as that which prevails in cities in general; namely that spatial configuration is critical, and that the spaces inside and outside railway termini have to become an 'integrated part' of the local system of pedestrian movement. In order to achieve this, space has to be re-engineered to overcome the current tendency of stations to work as urban 'negative attractors' through the effect of the large blockages they impose on the development of local patterns of natural movement, in spite of the station being in itself a 'point attractor'. A node can become a place when it also becomes a 'configurational attractor' in the local network

Translation and cultural adaptation of Charing Cross Venous Ulcer Questionnaire

BACKGROUND: The translation and cultural adaptation are steps that will allow an instrument created in a particular language and culture might be used in another cultural context. The Charing Cross Venous Ulcer Questionnaire (CCVUQ) is a quality of life questionnaire in English for patients with venous ulcers that need to be translated and culturally adapted to be used in Brazil. OBJECTIVE: To translate and culturally adapt to the Brazilian the CCVUQ. METHODS: The process consisted of two translations and two back translations performed by freelance translators, evaluation of versions, followed by the development of consensus version and pre-test commented. RESULTS: In the process of translating some words and expressions were changed in its literal aspect. Pre-test evaluation indicated changes were needed for better understanding of the respondent. The average time to respond to the questionnaire was 5 minutes and 23 seconds. CONCLUSION: The Portuguese version of the Charing Cross Venous Ulcer Questionnaire was translated and adapted for use in Brazilian population.CONTEXTO: A tradução e a adaptação cultural são etapas que permitirão que um instrumento criado em determinado idioma e cultura possa ser usado em outro contexto cultural. O Charing Cross Venous Ulcer Questionnaire (CCVUQ) é um questionário de qualidade de vida em portadores de úlceras venosas que para ser utilizado no Brasil é necessária a execução do processo de adaptação transcultural. OBJETIVO: Traduzir e adaptar culturalmente para a população brasileira o CCVUQ. MÉTODOS: O processo consistiu em duas traduções e duas retrotraduções realizadas por tradutores independentes, da avaliação das versões, seguida da elaboração de versão consensual e de pré-teste comentado. RESULTADOS: No processo de tradução, algumas palavras foram modificadas no seu aspecto literal. A análise posterior dos resultados do pré-teste apontou necessidades de modificações de alguns termos para melhor compreensão do respondente. O tempo médio de aplicação do questionário foi de 5 minutos e 23 segundos. CONCLUSÃO: A versão na língua portuguesa do Charing Cross Venous Ulcer Questionnaire foi traduzida e adaptada para uso na população brasileira.Universidade Federal de São Paulo (UNIFESP)UNCISALEstácio Faculdade de Alagoas curso de FisioterapiaEnfermeira da Hemodiálise do Hospital Antonio TarginoHospital Regional de Trauma de Campina Grande Unidade de Terapia Intensiva InfantilClínica de Enfermagem Especializada em CurativosUNIFESP, EPM, São PauloSciEL

The normalization of the cyborg: from futuristic artistic expression of mutilation to daily aesthetic beauty

The concept of mutilation as a permanent scarring of the integrity of the body has been overcome by the representation in visual culture of the cyborg, the bionic human and the genetically and bionically engineered mutant. Mutants with bionic prosthetics in the X-Men film trilogy, the bionic man in The Six Million Dollar Man (1974) and his companion The Bionic Woman (1976) as well as The Terminator (1984) with its sequels have contributed to create a new aesthetic perception of the artificial. From the Cyborg Manifesto to theories of Post-humanism and Trans-humanism, the arts have embraced the opportunity of realizing the conjunction between human and machine envisaged at first by Tommaso Marinetti in the Futurist Manifesto. Stelarc has contributed with his performances and body implants to explore new aesthetic forms that conceive the prosthesis as an evolutionary empowering design. If in the arts this approach has created aesthetic debates and polarizations between bioconservatism and technoprogressivism, how is the reality of mutilation approached by people in their daily lives? The paper analyzes whether the aesthetic perception of prosthetics is that of a permanent sign of mutilation or that of a new technological empowerment. “In the last two to three years many men have asked to have prosthetics without coverage, leaving the metal part visible. They tell me that a leg like this is more futuristic! Maybe they feel more masculine because the metallic leg gives them the sensation of being bionic, half human and half machine. Men under fifty especially request it. At the opposite end of the spectrum, women ask for symmetric prosthetics very similar to the one they lost.” Interview with Dr. X at the Limb Fitting Centre, London. If the visual arts have created an experience and imagination of post-humanity as the futuristic merging of human and machine that the public perceives as increasingly achievable, what are the new frontiers of aesthetic exploration? Are the aesthetics of post-humanity becoming those of a ‘normalization’ of cyborgology? The paper will argue that the contemporary aesthetics of futuristic empowerment look to artists and designers in order to deliver new modes of aesthetic consumption for a technology no longer perceived as reconstruction of a mutilation but as the empowering necessary framework to facilitate the transition from human to super-human

Balance and gait adaptations in patients with early knee osteoarthritis

AbstractGait adaptations in people with severe knee osteoarthritis (OA) have been well documented, with increased knee adduction moments (KAM) the most commonly reported parameter. Neuromuscular adaptations have also been reported, including reduced postural control. However these adaptations may be the result of morphological changes in the joint, rather than the cause. This study aimed to determine if people with early OA have altered gait parameters and neuromuscular adaptations. Gait and postural tasks were performed by 18 people with early medial knee OA and 18 age and gender-matched control subjects. Parameters measured were kinematics and kinetics during gait and postural tasks, and centre of pressure and electromyographic activity during postural tasks. OA subjects showed no differences in the gait parameters measured, however they demonstrated postural deficits during one-leg standing on both their affected and unaffected sides and altered hip adduction moments compared with controls. Increased activity of the gluteus medius of both sides (p<0.05), and quadriceps and hamstrings of the affected side (p<0.05) during one-leg standing compared with controls were also noted. This study has demonstrated that gait adaptations commonly associated with OA do not occur in the early stages, while neuromuscular adaptations are evident. These results may be relevant for early interventions to delay or prevent osteoarthritis in its early stages

Clinical Research in Britain 1950-1980

Edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 June 1998. First published by the Wellcome Trust, 2000. ©The Trustee of the Wellcome Trust, London, 2000. All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.What is clinical research? The growth of clinical research in the UK since the Second World War is examined, including the 1953 Cohen Report and the subsequent creation of the Medical Research Council’s Clinical Research Board. Lord Walton of Detchant, as Chairman, guided the discussion on the inter-relationships between the MRC, the NHS, the Royal Colleges, other professional bodies and other funding organizations. Among other issues were the changes imposed by Government policy over the period, the influence of the early clinical research fellowships, growth of clinical career structures, planning of the Clinical Research Centre at Northwick Park, the tropical research units, and the effects of the Rothschild and Dainton reports on funding for clinical research and the role of the Chief Scientist. Participants include: Sir Douglas Black, Sir John Gray, Sir Raymond Hoffenberg, Dr Sheila Howarth, Professor Peter Lachmann, Sir Patrick Nairne, Professor Sir Stanley Peart and Dr Peter Williams. Reynolds L A, Tansey E M. (eds) (2000) Clinical research in Britain, 1950–1980, Wellcome Witnesses to Twentieth Century Medicine, vol. 7. London: The Wellcome Trust.The Wellcome Trust is a registered charity, no. 210183

ENDOTOXAEMIA, PULMONARY COMPLICATIONS, AND THROMBOCYTOPENIA IN LIVER TRANSPLANTATION

Plasma endotoxin was measured in 64 patients undergoing primary liver replacement. Endotoxin concentrations increased during the anhepatic phase of the operations, and remained high for several days. Although the severity of endotoxaemia did not correlate with duration of the anhepatic phase, there was a correlation between endotoxaemia and the need for perioperative platelet transfusions, ventilator dependency postoperatively, and one-month case-fatality

The role of the ventrolateral frontal cortex in inhibitory oculomotor control

It has been proposed that the inferior/ventrolateral frontal cortex plays a critical role in the inhibitory control of action during cognitive tasks.However, the contribution of this region to the control of eye movements has not been clearly established.Here, we describe the performance of a group of 23 frontal lobe damaged patients in an oculomotor rule switching task for which the association between a centrally presented visual cue and the direction of a saccade could change from trial to trial. A subset of 16 patients also completed the standard antisaccade task.Ventrolateral damage was found to be a significant predictor of errors in both tasks. Analysis of the rate at which patients corrected errors in the rule switching task also revealed an important dissociation between left and right hemisphere damaged patients.Whilst patients with left ventrolateral damage usually corrected response errors with secondary saccades, those with right hemisphere lesions often failed to do so. The results suggest that the inferior frontal cortex forms part of a wider frontal network mediating inhibitory control over stimulus elicited eye movements. The critical role played by the right ventrolateral region in cognitive tasks may arise due to an additional functional specialization for the monitoring and updating of task rules

A study protocol for a randomised crossover study evaluating the effect of diets differing in carbohydrate quality on ileal content and appetite regulation in healthy humans

A major component of the digesta reaching the colon from the distal ileum is carbohydrate. This carbohydrate is subject to microbial fermentation and can radically change bacterial populations in the colon and the metabolites they produce, particularly short-chain fatty acids (SCFA). However, very little is currently known about the forms and levels of carbohydrate in the ileum and the composition of the ileal microbiota in humans. Most of our current understanding of carbohydrate that is not absorbed by the small intestine comes from ileostomy models, which may not reflect the physiology of an intact gastrointestinal tract. We will investigate how ileal content changes depending on diet using a randomised crossover study in healthy humans. Participants will be inpatients at the research facility for three separate 4-day visits. During each visit, participants will consume one of three diets, which differ in carbohydrate quality: 1) low-fibre refined diet; 2) high-fibre diet with intact cellular structures; 3) high-fibre diet where the cellular structures have been disrupted (e.g. milling, blending). On day 1, a nasoenteric tube will be placed into the distal ileum and its position confirmed under fluoroscopy. Ileal samples will be collected via the nasoenteric tube and metabolically profiled, which will determine the amount and type of carbohydrate present, and the composition of the ileal microbiota will be measured. Blood samples will be collected to assess circulating hormones and metabolites. Stool samples will be collected to assess faecal microbiota composition. Subjective appetite measures will be collected using visual analogue scales. Breath hydrogen will be measured in real-time as a marker of intestinal fermentation. Finally, an continuous fermentation model will be inoculated with ileal fluid in order to understand the shift in microbial composition and SCFA produced in the colon following the different diets. ISRCTN11327221. [Abstract copyright: Copyright: © 2019 Byrne CS et al.