Aerospace medicine and biology: A continuing bibliography with indexes, supplement 204

This bibliography lists 140 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1980

RESEARCH TOWARDS THE DESIGN OF A NOVEL SMART FLUID DAMPER USING A MCKIBBEN ACTUATOR

Vibration reducing performance of many mechanical systems, decreasing the quality of manufactured products, producing noise, generating fatigue in mechanical components, and producing an uncomfortable environment for human bodies. Vibration control is categorized as: active, passive, or semi-active, based on the power consumption of the control system and feedback or feed forward based on whether sensing is used to control vibration. Semi-active vibration control is the most attractive method; one method of semi-active vibration control could be designed by using smart fluid. Smart fluids are able to modify their effective viscosity in response to an external stimulus such as a magnetic field. This unique characteristic can be utilised to build semi-active dampers for a wide variety of vibration control systems. Previous work has studied the application of smart fluids in semi-active dampers, where the kinetic energy of a vibrating structure can be dissipated in a controllable fashion. A McKibben actuator is a device that consists of a rubber tube surrounded by braided fibre material. It has different advantages over a piston/cylinder actuator such as: a high power to weight ratio, low weight and less cost. Recently McKibben actuator has appeared in some semi-active vibration control devise. This report investigates the possibility of designing a Magnetorheological MR damper that seeks to reduce the friction in the device by integrating it with a McKibben actuator. In this thesis the concept of both smart fluid and McKibben actuator have been reviewed in depth, and methods of modelling and previous applications of devices made using these materials are also presented. The experimental part of the research includes: designing and modelling a McKibben actuator (using water) under static loads, and validating the model experimentally. The research ends by presenting conclusions and future work

Novel homozygous GBA2 mutation in a patient with complicated spastic paraplegia

Hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurological disorders characterized primarily by a pyramidal syndrome with lower limb spasticity, which can manifest as pure HSP or associated with a number of neurological or non-neurological signs (i.e., complicated HSPs). The clinical variability of HSPs is associated with a wide genetic heterogeneity, with more than eighty causative genes known. Recently, next generation sequencing (NGS) has allowed increasing genetic definition in such a heterogeneous group of disorders. We report on a 56- year-old man affected by sporadic complicated HSP consisting of a pyramidal syndrome, cerebellar ataxia, congenital cataract, pes cavus, axonal sensory-motor peripheral neuropathy and cognitive decline. Brain MRI showed cerebellar atrophy and thin corpus callosum. By NGS we found a novel homozygous biallelic c.452-1G > C mutation in the b-glucosidase 2 gene (GBA2), known to be causative for autosomal recessive hereditary spastic paraplegia type 46 (SPG46). The rarity of this inherited form besides reporting on a novel mutation, expands the genetic and clinical spectrum of SPG46 related HSP

Estimation of the mechanical properties of the eye through the study of its vibrational modes

Measuring the eye's mechanical properties in vivo and with minimally invasive techniques can be the key for individualized solutions to a number of eye pathologies. The development of such techniques largely relies on a computational modelling of the eyeball and, it optimally requires the synergic interplay between experimentation and numerical simulation. In Astrophysics and Geophysics the remote measurement of structural properties of the systems of their realm is performed on the basis of (helio-)seismic techniques. As a biomechanical system, the eyeball possesses normal vibrational modes encompassing rich information about its structure and mechanical properties. However, the integral analysis of the eyeball vibrational modes has not been performed yet. Here we develop a new finite difference method to compute both the spheroidal and, specially, the toroidal eigenfrequencies of the human eye. Using this numerical model, we show that the vibrational eigenfrequencies of the human eye fall in the interval 100 Hz - 10 MHz. We find that compressible vibrational modes may release a trace on high frequency changes of the intraocular pressure, while incompressible normal modes could be registered analyzing the scattering pattern that the motions of the vitreous humour leave on the retina. Existing contact lenses with embebed devices operating at high sampling frequency could be used to register the microfluctuations of the eyeball shape we obtain. We advance that an inverse problem to obtain the mechanical properties of a given eye (e.g., Young's modulus, Poisson ratio) measuring its normal frequencies is doable. These measurements can be done using non-invasive techniques, opening very interesting perspectives to estimate the mechanical properties of eyes in vivo. Future research might relate various ocular pathologies with anomalies in measured vibrational frequencies of the eye.Comment: Published in PLoS ONE as Open Access Research Article. 17 pages, 5 color figure

EVA Glove Research Team

The goal of the basic research portion of the extravehicular activity (EVA) glove research program is to gain a greater understanding of the kinematics of the hand, the characteristics of the pressurized EVA glove, and the interaction of the two. Examination of the literature showed that there existed no acceptable, non-invasive method of obtaining accurate biomechanical data on the hand. For this reason a project was initiated to develop magnetic resonance imaging as a tool for biomechanical data acquisition and visualization. Literature reviews also revealed a lack of practical modeling methods for fabric structures, so a basic science research program was also initiated in this area