A Comparative Study on the Methods Used for the Detection of Breast Cancer

Among women in the world, the death caused by the Breast cancer has become the leading role. At an initial stage, the tumor in the breast is hard to detect. Manual attempt have proven to be time consuming and inefficient in many cases. Hence there is a need for efficient methods that diagnoses the cancerous cell without human involvement with high accuracy. Mammography is a special case of CT scan which adopts X-ray method with high resolution film. so that it can detect well the tumors in the breast. This paper describes the comparative study of the various data mining methods on the detection of the breast cancer by using image processing techniques

Enhanced Artificial Intelligence System for Diagnosing and Predicting Breast Cancer Using Deep Learning

Breast cancer is the leading cause of death among women with cancer. Computer-aided diagnosis is an efficient method for assisting medical experts in early diagnosis, improving the chance of recovery. Employing artificial intelligence (AI) in the medical area is very crucial due to the sensitivity of this field. This means that the low accuracy of the classification methods used for cancer detection is a critical issue. This problem is accentuated when it comes to blurry mammogram images. In this paper, convolutional neural networks (CNNs) are employed to present the traditional convolutional neural network (TCNN) and supported convolutional neural network (SCNN) approaches. The TCNN and SCNN approaches contribute by overcoming the shift and scaling problems included in blurry mammogram images. In addition, the flipped rotation-based approach (FRbA) is proposed to enhance the accuracy of the prediction process (classification of the type of cancerous mass) by taking into account the different directions of the cancerous mass to extract effective features to form the map of the tumour. The proposed approaches are implemented on the MIAS medical dataset using 200 mammogram breast images. Compared to similar approaches based on KNN and RF, the proposed approaches show better performance in terms of accuracy, sensitivity, spasticity, precision, recall, time of performance, and quality of image metrics

Image processing and machine learning techniques used in computer-aided detection system for mammogram screening - a review

This paper aims to review the previously developed Computer-aided detection (CAD) systems for mammogram screening because increasing death rate in women due to breast cancer is a global medical issue and it can be controlled only by early detection with regular screening. Till now mammography is the widely used breast imaging modality. CAD systems have been adopted by the radiologists to increase the accuracy of the breast cancer diagnosis by avoiding human errors and experience related issues. This study reveals that in spite of the higher accuracy obtained by the earlier proposed CAD systems for breast cancer diagnosis, they are not fully automated. Moreover, the false-positive mammogram screening cases are high in number and over-diagnosis of breast cancer exposes a patient towards harmful overtreatment for which a huge amount of money is being wasted. In addition, it is also reported that the mammogram screening result with and without CAD systems does not have noticeable difference, whereas the undetected cancer cases by CAD system are increasing. Thus, future research is required to improve the performance of CAD system for mammogram screening and make it completely automated

Artificial neural network and its applications in quality process control, document recognition and biomedical imaging

In computer-vision based system a digital image obtained by a digital camera would usually have 24-bit color image. The analysis of an image with that many levels might require complicated image processing techniques and higher computational costs. But in real-time application, where a part has to be inspected within a few milliseconds, either we have to reduce the image to a more manageable number of gray levels, usually two levels (binary image), and at the same time retain all necessary features of the original image or develop a complicated technique. A binary image can be obtained by thresholding the original image into two levels. Therefore, thresholding of a given image into binary image is a necessary step for most image analysis and recognition techniques. In this thesis, we have studied the effectiveness of using artificial neural network (ANN) in pharmaceutical, document recognition and biomedical imaging applications for image thresholding and classification purposes. Finally, we have developed edge-based, ANN-based and region-growing based image thresholding techniques to extract low contrast objects of interest and classify them into respective classes in those applications. Real-time quality inspection of gelatin capsules in pharmaceutical applications is an important issue from the point of view of industry\u27s productivity and competitiveness. Computer vision-based automatic quality inspection and controller system is one of the solutions to this problem. Machine vision systems provide quality control and real-time feedback for industrial processes, overcoming physical limitations and subjective judgment of humans. In this thesis, we have developed an image processing system using edge-based image thresholding techniques for quality inspection that satisfy the industrial requirements in pharmaceutical applications to pass the accepted and rejected capsules. In document recognition application, success of OCR mostly depends on the quality of the thresholded image. Non-uniform illumination, low contrast and complex background make it challenging in this application. In this thesis, optimal parameters for ANN-based local thresholding approach for gray scale composite document image with non-uniform background is proposed. An exhaustive search was conducted to select the optimal features and found that pixel value, mean and entropy are the most significant features at window size 3x3 in this application. For other applications, it might be different, but the procedure to find the optimal parameters is same. The average recognition rate 99.25% shows that the proposed 3 features at window size 3x3 are optimal in terms of recognition rate and PSNR compare to the ANN-based thresholding technique with different parameters presented in the literature. In biomedical imaging application, breast cancer continues to be a public health problem. In this thesis we presented a computer aided diagnosis (CAD) system for mass detection and classification in digitized mammograms, which performs mass detection on regions of interest (ROI) followed by the benign-malignant classification on detected masses. Three layers ANN with seven features is proposed for classifying the marked regions into benign and malignant and 90.91% sensitivity and 83.87% specificity is achieved that is very much promising compare to the radiologist\u27s sensitivity 75%

Enhanced algorithms for lesion detection and recognition in ultrasound breast images

Mammography is the gold standard for breast cancer detection. However, it has very high false positive rates and is based on ionizing radiation. This has led to interest in using multi-modal approaches. One modality is diagnostic ultrasound, which is based on non-ionizing radiation and picks up many of the cancers that are generally missed by mammography. However, the presence of speckle noise in ultrasound images has a negative effect on image interpretation. Noise reduction, inconsistencies in capture and segmentation of lesions still remain challenging open research problems in ultrasound images. The target of the proposed research is to enhance the state-of-art computer vision algorithms used in ultrasound imaging and to investigate the role of computer processed images in human diagnostic performance. [Continues.

Cluster analysis of the signal curves in perfusion DCE-MRI datasets

Pathological studies show that tumors consist of different sub-regions with more homogeneous vascular properties during their growth. In addition, destroying tumor's blood supply is the target of most cancer therapies. Finding the sub-regions in the tissue of interest with similar perfusion patterns provides us with valuable information about tissue structure and angiogenesis. This information on cancer therapy, for example, can be used in monitoring the response of the cancer treatment to the drug. Cluster analysis of perfusion curves assays to find sub-regions with a similar perfusion pattern. The present work focuses on the cluster analysis of perfusion curves, measured by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). The study, besides searching for the proper clustering method, follows two other major topics, the choice of an appropriate similarity measure, and determining the number of clusters. These three subjects are connected to each other in such a way that success in one direction will help solving the other problems. This work introduces a new similarity measure, parallelism measure (PM), for comparing the parallelism in the washout phase of the signal curves. Most of the previous works used the Euclidean distance as the measure of dissimilarity. However, the Euclidean distance does not take the patterns of the signal curves into account and therefore for comparing the signal curves is not sufficient. To combine the advantages of both measures a two-steps clustering is developed. The two-steps clustering uses two different similarity measures, the introduced PM measure and Euclidean distance in two consecutive steps. The results of two-steps clustering are compared with the results of other clustering methods. The two-steps clustering besides good performance has some other advantages. The granularity and the number of clusters are controlled by thresholds defined by considering the noise in signal curves. The method is easy to implement and is robust against noise. The focus of the work is mainly the cluster analysis of breast tumors in DCE-MRI datasets. The possibility to adopt the method for liver datasets is studied as well

Computer-aided detection and diagnosis of breast cancer in 2D and 3D medical imaging through multifractal analysis

This Thesis describes the research work performed in the scope of a doctoral research program and presents its conclusions and contributions. The research activities were carried on in the industry with Siemens S.A. Healthcare Sector, in integration with a research team. Siemens S.A. Healthcare Sector is one of the world biggest suppliers of products, services and complete solutions in the medical sector. The company offers a wide selection of diagnostic and therapeutic equipment and information systems. Siemens products for medical imaging and in vivo diagnostics include: ultrasound, computer tomography, mammography, digital breast tomosynthesis, magnetic resonance, equipment to angiography and coronary angiography, nuclear imaging, and many others. Siemens has a vast experience in Healthcare and at the beginning of this project it was strategically interested in solutions to improve the detection of Breast Cancer, to increase its competitiveness in the sector. The company owns several patents related with self-similarity analysis, which formed the background of this Thesis. Furthermore, Siemens intended to explore commercially the computer- aided automatic detection and diagnosis eld for portfolio integration. Therefore, with the high knowledge acquired by University of Beira Interior in this area together with this Thesis, will allow Siemens to apply the most recent scienti c progress in the detection of the breast cancer, and it is foreseeable that together we can develop a new technology with high potential. The project resulted in the submission of two invention disclosures for evaluation in Siemens A.G., two articles published in peer-reviewed journals indexed in ISI Science Citation Index, two other articles submitted in peer-reviewed journals, and several international conference papers. This work on computer-aided-diagnosis in breast led to innovative software and novel processes of research and development, for which the project received the Siemens Innovation Award in 2012. It was very rewarding to carry on such technological and innovative project in a socially sensitive area as Breast Cancer.No cancro da mama a deteção precoce e o diagnóstico correto são de extrema importância na prescrição terapêutica e caz e e ciente, que potencie o aumento da taxa de sobrevivência à doença. A teoria multifractal foi inicialmente introduzida no contexto da análise de sinal e a sua utilidade foi demonstrada na descrição de comportamentos siológicos de bio-sinais e até na deteção e predição de patologias. Nesta Tese, três métodos multifractais foram estendidos para imagens bi-dimensionais (2D) e comparados na deteção de microcalci cações em mamogramas. Um destes métodos foi também adaptado para a classi cação de massas da mama, em cortes transversais 2D obtidos por ressonância magnética (RM) de mama, em grupos de massas provavelmente benignas e com suspeição de malignidade. Um novo método de análise multifractal usando a lacunaridade tri-dimensional (3D) foi proposto para classi cação de massas da mama em imagens volumétricas 3D de RM de mama. A análise multifractal revelou diferenças na complexidade subjacente às localizações das microcalci cações em relação aos tecidos normais, permitindo uma boa exatidão da sua deteção em mamogramas. Adicionalmente, foram extraídas por análise multifractal características dos tecidos que permitiram identi car os casos tipicamente recomendados para biópsia em imagens 2D de RM de mama. A análise multifractal 3D foi e caz na classi cação de lesões mamárias benignas e malignas em imagens 3D de RM de mama. Este método foi mais exato para esta classi cação do que o método 2D ou o método padrão de análise de contraste cinético tumoral. Em conclusão, a análise multifractal fornece informação útil para deteção auxiliada por computador em mamogra a e diagnóstico auxiliado por computador em imagens 2D e 3D de RM de mama, tendo o potencial de complementar a interpretação dos radiologistas

Analysis of contrast-enhanced medical images.

Early detection of human organ diseases is of great importance for the accurate diagnosis and institution of appropriate therapies. This can potentially prevent progression to end-stage disease by detecting precursors that evaluate organ functionality. In addition, it also assists the clinicians for therapy evaluation, tracking diseases progression, and surgery operations. Advances in functional and contrast-enhanced (CE) medical images enabled accurate noninvasive evaluation of organ functionality due to their ability to provide superior anatomical and functional information about the tissue-of-interest. The main objective of this dissertation is to develop a computer-aided diagnostic (CAD) system for analyzing complex data from CE magnetic resonance imaging (MRI). The developed CAD system has been tested in three case studies: (i) early detection of acute renal transplant rejection, (ii) evaluation of myocardial perfusion in patients with ischemic heart disease after heart attack; and (iii), early detection of prostate cancer. However, developing a noninvasive CAD system for the analysis of CE medical images is subject to multiple challenges, including, but are not limited to, image noise and inhomogeneity, nonlinear signal intensity changes of the images over the time course of data acquisition, appearances and shape changes (deformations) of the organ-of-interest during data acquisition, determination of the best features (indexes) that describe the perfusion of a contrast agent (CA) into the tissue. To address these challenges, this dissertation focuses on building new mathematical models and learning techniques that facilitate accurate analysis of CAs perfusion in living organs and include: (i) accurate mathematical models for the segmentation of the object-of-interest, which integrate object shape and appearance features in terms of pixel/voxel-wise image intensities and their spatial interactions; (ii) motion correction techniques that combine both global and local models, which exploit geometric features, rather than image intensities to avoid problems associated with nonlinear intensity variations of the CE images; (iii) fusion of multiple features using the genetic algorithm. The proposed techniques have been integrated into CAD systems that have been tested in, but not limited to, three clinical studies. First, a noninvasive CAD system is proposed for the early and accurate diagnosis of acute renal transplant rejection using dynamic contrast-enhanced MRI (DCE-MRI). Acute rejection–the immunological response of the human immune system to a foreign kidney–is the most sever cause of renal dysfunction among other diagnostic possibilities, including acute tubular necrosis and immune drug toxicity. In the U.S., approximately 17,736 renal transplants are performed annually, and given the limited number of donors, transplanted kidney salvage is an important medical concern. Thus far, biopsy remains the gold standard for the assessment of renal transplant dysfunction, but only as the last resort because of its invasive nature, high cost, and potential morbidity rates. The diagnostic results of the proposed CAD system, based on the analysis of 50 independent in-vivo cases were 96% with a 95% confidence interval. These results clearly demonstrate the promise of the proposed image-based diagnostic CAD system as a supplement to the current technologies, such as nuclear imaging and ultrasonography, to determine the type of kidney dysfunction. Second, a comprehensive CAD system is developed for the characterization of myocardial perfusion and clinical status in heart failure and novel myoregeneration therapy using cardiac first-pass MRI (FP-MRI). Heart failure is considered the most important cause of morbidity and mortality in cardiovascular disease, which affects approximately 6 million U.S. patients annually. Ischemic heart disease is considered the most common underlying cause of heart failure. Therefore, the detection of the heart failure in its earliest forms is essential to prevent its relentless progression to premature death. While current medical studies focus on detecting pathological tissue and assessing contractile function of the diseased heart, this dissertation address the key issue of the effects of the myoregeneration therapy on the associated blood nutrient supply. Quantitative and qualitative assessment in a cohort of 24 perfusion data sets demonstrated the ability of the proposed framework to reveal regional perfusion improvements with therapy, and transmural perfusion differences across the myocardial wall; thus, it can aid in follow-up on treatment for patients undergoing the myoregeneration therapy. Finally, an image-based CAD system for early detection of prostate cancer using DCE-MRI is introduced. Prostate cancer is the most frequently diagnosed malignancy among men and remains the second leading cause of cancer-related death in the USA with more than 238,000 new cases and a mortality rate of about 30,000 in 2013. Therefore, early diagnosis of prostate cancer can improve the effectiveness of treatment and increase the patient’s chance of survival. Currently, needle biopsy is the gold standard for the diagnosis of prostate cancer. However, it is an invasive procedure with high costs and potential morbidity rates. Additionally, it has a higher possibility of producing false positive diagnosis due to relatively small needle biopsy samples. Application of the proposed CAD yield promising results in a cohort of 30 patients that would, in the near future, represent a supplement of the current technologies to determine prostate cancer type. The developed techniques have been compared to the state-of-the-art methods and demonstrated higher accuracy as shown in this dissertation. The proposed models (higher-order spatial interaction models, shape models, motion correction models, and perfusion analysis models) can be used in many of today’s CAD applications for early detection of a variety of diseases and medical conditions, and are expected to notably amplify the accuracy of CAD decisions based on the automated analysis of CE images