6,460 research outputs found
The evidence for automated grading in diabetic retinopathy screening
Peer reviewedPostprin
Weakly-supervised localization of diabetic retinopathy lesions in retinal fundus images
Convolutional neural networks (CNNs) show impressive performance for image
classification and detection, extending heavily to the medical image domain.
Nevertheless, medical experts are sceptical in these predictions as the
nonlinear multilayer structure resulting in a classification outcome is not
directly graspable. Recently, approaches have been shown which help the user to
understand the discriminative regions within an image which are decisive for
the CNN to conclude to a certain class. Although these approaches could help to
build trust in the CNNs predictions, they are only slightly shown to work with
medical image data which often poses a challenge as the decision for a class
relies on different lesion areas scattered around the entire image. Using the
DiaretDB1 dataset, we show that on retina images different lesion areas
fundamental for diabetic retinopathy are detected on an image level with high
accuracy, comparable or exceeding supervised methods. On lesion level, we
achieve few false positives with high sensitivity, though, the network is
solely trained on image-level labels which do not include information about
existing lesions. Classifying between diseased and healthy images, we achieve
an AUC of 0.954 on the DiaretDB1.Comment: Accepted in Proc. IEEE International Conference on Image Processing
(ICIP), 201
A robust lesion boundary segmentation algorithm using level set methods
This paper addresses the issue of accurate lesion segmentation in retinal imagery, using level set methods and
a novel stopping mechanism - an elementary features scheme. Specifically, the curve propagation is guided
by a gradient map built using a combination of histogram equalization and robust statistics. The stopping
mechanism uses elementary features gathered as the curve deforms over time, and then using a lesionness
measure, defined herein, ’looks back in time’ to find the point at which the curve best fits the real object.
We compare the proposed method against five other
segmentation algorithms performed on 50 randomly selected images of exudates with a database of clinician
demarcated boundaries as ground truth
Colour normalisation to reduce inter-patient and intra-patient variability in microaneurysm detection in colour retinal images
Images of the human retina vary considerably in their appearance depending on the skin pigmentation (amount of melanin) of the subject. Some form of normalisation of colour in retinal images is required for automated analysis of images if good sensitivity and specificity at detecting lesions is to be achieved in populations involving diverse races. Here we describe an approach to colour normalisation by shade-correction intra-image and histogram normalisation inter-image. The colour normalisation is assessed by its effect on the automated detection of microaneurysms in retinal images. It is shown that the Na¨ıve Bayes classifier used in microaneurysm detection benefits from the use of features measured over colour normalised images
Improving the economic value of photographic screening for optical coherence tomography-detectable macular oedema : a prospective, multicentre, UK study
Peer reviewedPublisher PD
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