brainlife.io: A decentralized and open source cloud platform to support neuroscience research

Neuroscience research has expanded dramatically over the past 30 years by advancing standardization and tool development to support rigor and transparency. Consequently, the complexity of the data pipeline has also increased, hindering access to FAIR data analysis to portions of the worldwide research community. brainlife.io was developed to reduce these burdens and democratize modern neuroscience research across institutions and career levels. Using community software and hardware infrastructure, the platform provides open-source data standardization, management, visualization, and processing and simplifies the data pipeline. brainlife.io automatically tracks the provenance history of thousands of data objects, supporting simplicity, efficiency, and transparency in neuroscience research. Here brainlife.io's technology and data services are described and evaluated for validity, reliability, reproducibility, replicability, and scientific utility. Using data from 4 modalities and 3,200 participants, we demonstrate that brainlife.io's services produce outputs that adhere to best practices in modern neuroscience research

Deep Learning-Based Robotic Perception for Adaptive Facility Disinfection

Hospitals, schools, airports, and other environments built for mass gatherings can become hot spots for microbial pathogen colonization, transmission, and exposure, greatly accelerating the spread of infectious diseases across communities, cities, nations, and the world. Outbreaks of infectious diseases impose huge burdens on our society. Mitigating the spread of infectious pathogens within mass-gathering facilities requires routine cleaning and disinfection, which are primarily performed by cleaning staff under current practice. However, manual disinfection is limited in terms of both effectiveness and efficiency, as it is labor-intensive, time-consuming, and health-undermining. While existing studies have developed a variety of robotic systems for disinfecting contaminated surfaces, those systems are not adequate for intelligent, precise, and environmentally adaptive disinfection. They are also difficult to deploy in mass-gathering infrastructure facilities, given the high volume of occupants. Therefore, there is a critical need to develop an adaptive robot system capable of complete and efficient indoor disinfection. The overarching goal of this research is to develop an artificial intelligence (AI)-enabled robotic system that adapts to ambient environments and social contexts for precise and efficient disinfection. This would maintain environmental hygiene and health, reduce unnecessary labor costs for cleaning, and mitigate opportunity costs incurred from infections. To these ends, this dissertation first develops a multi-classifier decision fusion method, which integrates scene graph and visual information, in order to recognize patterns in human activity in infrastructure facilities. Next, a deep-learning-based method is proposed for detecting and classifying indoor objects, and a new mechanism is developed to map detected objects in 3D maps. A novel framework is then developed to detect and segment object affordance and to project them into a 3D semantic map for precise disinfection. Subsequently, a novel deep-learning network, which integrates multi-scale features and multi-level features, and an encoder network are developed to recognize the materials of surfaces requiring disinfection. Finally, a novel computational method is developed to link the recognition of object surface information to robot disinfection actions with optimal disinfection parameters

Unsupervised cell segmentation and labelling in neural tissue images

Neurodegenerative diseases are a group of largely incurable disorders characterised by the progressive loss of neurons and for which often the molecular mechanisms are poorly understood. To bridge this gap, researchers employ a range of techniques. A very prominent and useful technique adopted across many different fields is imaging and the analysis of histopathological and fluorescent label tissue samples. Although image acquisition has been efficiently automated recently, automated analysis still presents a bottleneck. Although various methods have been developed to automate this task, they tend to make use of single-purpose machine learning models that require extensive training, imposing a significant workload on the experts and introducing variability in the analysis. Moreover, these methods are impractical to audit and adapt, as their internal parameters are difficult to interpret and change. Here, we present a novel unsupervised automated schema for object segmentation of images, exemplified on a dataset of tissue images. Our schema does not require training data, can be fully audited and is based on a series of understandable biological decisions. In order to evaluate and validate our schema, we compared it with a state-of-the-art automated segmentation method for post-mortem tissues of ALS patients

A Survey of Multimodal Information Fusion for Smart Healthcare: Mapping the Journey from Data to Wisdom

Multimodal medical data fusion has emerged as a transformative approach in smart healthcare, enabling a comprehensive understanding of patient health and personalized treatment plans. In this paper, a journey from data to information to knowledge to wisdom (DIKW) is explored through multimodal fusion for smart healthcare. We present a comprehensive review of multimodal medical data fusion focused on the integration of various data modalities. The review explores different approaches such as feature selection, rule-based systems, machine learning, deep learning, and natural language processing, for fusing and analyzing multimodal data. This paper also highlights the challenges associated with multimodal fusion in healthcare. By synthesizing the reviewed frameworks and theories, it proposes a generic framework for multimodal medical data fusion that aligns with the DIKW model. Moreover, it discusses future directions related to the four pillars of healthcare: Predictive, Preventive, Personalized, and Participatory approaches. The components of the comprehensive survey presented in this paper form the foundation for more successful implementation of multimodal fusion in smart healthcare. Our findings can guide researchers and practitioners in leveraging the power of multimodal fusion with the state-of-the-art approaches to revolutionize healthcare and improve patient outcomes.Comment: This work has been submitted to the ELSEVIER for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessibl

COVID-19-related studies of nonprofit management: A critical review and research agenda

During crises such as the present coronavirus disease-19 (COVID-19) pandemic, nonprofits play a key role in ensuring support to improve the most vulnerable individuals’ health, social, and economic conditions. One year into the COVID-19 pandemic, an extensive automated literature analysis was conducted of 154 academic articles on nonprofit management during the pandemic—all of which were published in 2020. This study sought to identify and systematize academics’ contributions to knowledge about the crisis’s impact on the nonprofit sector and to ascertain the most urgent directions for future research. The results provide policymakers, nonprofit practitioners, and scholars an overview of the themes addressed and highlight the important assistance academic researchers provide to nonprofits dealing with the COVID-19 pandemic.info:eu-repo/semantics/acceptedVersio

Towards Secure and Intelligent Diagnosis: Deep Learning and Blockchain Technology for Computer-Aided Diagnosis Systems

Cancer is the second leading cause of death across the world after cardiovascular disease. The survival rate of patients with cancerous tissue can significantly decrease due to late-stage diagnosis. Nowadays, advancements of whole slide imaging scanners have resulted in a dramatic increase of patient data in the domain of digital pathology. Large-scale histopathology images need to be analyzed promptly for early cancer detection which is critical for improving patient's survival rate and treatment planning. Advances of medical image processing and deep learning methods have facilitated the extraction and analysis of high-level features from histopathological data that could assist in life-critical diagnosis and reduce the considerable healthcare cost associated with cancer. In clinical trials, due to the complexity and large variance of collected image data, developing computer-aided diagnosis systems to support quantitative medical image analysis is an area of active research. The first goal of this research is to automate the classification and segmentation process of cancerous regions in histopathology images of different cancer tissues by developing models using deep learning-based architectures. In this research, a framework with different modules is proposed, including (1) data pre-processing, (2) data augmentation, (3) feature extraction, and (4) deep learning architectures. Four validation studies were designed to conduct this research. (1) differentiating benign and malignant lesions in breast cancer (2) differentiating between immature leukemic blasts and normal cells in leukemia cancer (3) differentiating benign and malignant regions in lung cancer, and (4) differentiating benign and malignant regions in colorectal cancer. Training machine learning models, disease diagnosis, and treatment often requires collecting patients' medical data. Privacy and trusted authenticity concerns make data owners reluctant to share their personal and medical data. Motivated by the advantages of Blockchain technology in healthcare data sharing frameworks, the focus of the second part of this research is to integrate Blockchain technology in computer-aided diagnosis systems to address the problems of managing access control, authentication, provenance, and confidentiality of sensitive medical data. To do so, a hierarchical identity and attribute-based access control mechanism using smart contract and Ethereum Blockchain is proposed to securely process healthcare data without revealing sensitive information to an unauthorized party leveraging the trustworthiness of transactions in a collaborative healthcare environment. The proposed access control mechanism provides a solution to the challenges associated with centralized access control systems and ensures data transparency and traceability for secure data sharing, and data ownership

Internet of Things (IoT) for Automated and Smart Applications

Internet of Things (IoT) is a recent technology paradigm that creates a global network of machines and devices that are capable of communicating with each other. Security cameras, sensors, vehicles, buildings, and software are examples of devices that can exchange data between each other. IoT is recognized as one of the most important areas of future technologies and is gaining vast recognition in a wide range of applications and fields related to smart homes and cities, military, education, hospitals, homeland security systems, transportation and autonomous connected cars, agriculture, intelligent shopping systems, and other modern technologies. This book explores the most important IoT automated and smart applications to help the reader understand the principle of using IoT in such applications