Acetylsalicylate and salicylates in foods

Acetylsalicylic acid is effective in the prevention of cardiovascular disease. It was suggested that fruits and vegetables provide unknown amounts of acetylsalicylic acid. We could not find any acetylsalicylic acid in 30 foods using HPLC with fluorescence detection (detection limits: 0.02 mg/kg for fresh, and 0.2 mg/kg for dried products). We showed that urinary excretion of salicylates is a valid indicator for intake, and found a median salicylate excretion of 10 mol (1.4 mg) in 24 h urine of 17 volunteers eating a variety of diets. Our data suggest that the content of (acetyl)salicylic acid of diets may be too low to affect disease risk

Heart Disease, Diabetes, Gut Immune Suppression and Epidemiology Studies

Abstrac

100 kV versus 120 kV: effective reduction in radiation dose?

Atherosclerosi

The findings of the oesophageal echocardiography in patients with acute cerebral ischaemia

AbstractIntroductionThe cerebrovascular accident ranks among the main causes of mortality and morbidity worldwide. In the Czech Republic, the cerebrovascular disease was the direct cause of death in 10% of the cases in the year 2012 (Healthcare Annual CZ 2012).AimThe aim of our study was to evaluate the transoesophageal echocardiogram findings (TOE) in patients with suspicion for cardioembolic stroke or TIA who were indicated to this examination in our echocardiography laboratory.MethodologyDuring the period from July 2009 to March 2013 (45 months), 108 TOE had been realized in our echocardiographic laboratory that was indicated for ischaemic stroke or TIA. We monitored the occurrence of pathological findings that have the cardioembolic potential according to the literature.ResultsThe examination was performed for a suspect of an infective endocarditis 10 times, this was proven in 3 cases. 5 patients were holders of a mechanical valvular prosthesis, and its dysfunction was discovered in neither case. The most frequent diagnosis was foramen ovale patens in the other patients (30 patients, i.e. 37%); in 3 cases it occurred simultaneously with an atrial septal aneurysm. We found a haemodynamic little significant atrial septal defect in 3 patients and a presence of an endocardial thrombus in 2 patients. A left atrial dilation and a systolic dysfunction of a left atrium auricle can relate with an occurrence of an atrial fibrillation. A left atrium volume was determined in 86 cases; only 35 patients (i.e. 40.7%) have the normal left atrium volume. A pathology, which can be connected with a cerebral ischaemia that took place, was found in 56% of the patients.ConclusionTransoesophageal echocardiography is an independent method in examination of potential sources of cardioembolism. In our sample, a pathology in more than half of the patients was diagnosed that could refer to a suffered ischaemic stroke and the diagnosis led to a change in a treatment strategy in 17 cases of the total number of 95 patients (i.e. at 18%)

An intriguing autopsy case of gangrene intestine

Background Hashimoto’s thyroiditis is one of the most common causes of hypothyroidism. Hypothyroidism is a known cause of hyperlipidemia. There is a strong correlation between coronary and mesenteric vessel atherosclerosis. Acute mesenteric ischemia is a cause of intestinal hemorrhagic infarction. Case history We present an autopsy case of 35-year-old male who presented with features of obstruction and edema with previously undetected hypothyroidism. Conclusion Hypothyroidism associated with atherosclerosis can lead to fatal intestinal gangrene as corroborated by this autopsy case. Key words –Hypothyroidism, intestinal gangrene, autopsy, atherosclerosi

Antiplatelet therapy and the vascular tree

While treatment with aspirin plus clopidogrel may be valid as an adjunct to percutaneous coronary intervention, other issues remain to be addressed before routine combination therapy is recommended for any level of atherosclerosi

THE EFFECT OF EGGPLANT JUICE TO THE THICKNESS OF AORTIC WALL IN WHITE RAT

Atherosclerosis is a complex chronic disease characterized by the accumulation of lipids within arterial walls. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple-colored crystals from eggplant peels. Nasunin protection against induced lipid peroxidation in rat. The aim of study was to determine the effect of eggplant juice to the thickness of aortic wall of white rat with atherogenic diet. This true experimental laboratoric study using control group post test design performed in white rat that placed in pharmacologic laboratory of Brawijaya University. Sampling was carried out by completely random sampling with 25 rats for the total sample. Data were processed and analyzed using SPSS 16. Statistical test using one-way ANOVA and continuing with post hoc Tukey. The result showed there was a significant effect between positive control of diet atherogenic with the dosage I (1,3 gr/3 ml), dosage II (2,6 gr/3 ml), and dosage III (5,2 gr/3 ml) of eggplant juice to aorta wall thickness (p=0,000;