The Mesh Archetype

A parallel program archetype [2] aids in the development of reliable, efficient parallel applications with common computation/communication structures by providing development methods and code libraries specific to the structure. This document presents an archetype for mesh-spectral computations. It describes the common structure captured by the archetype abstraction, discusses a parallelization strategy for such computations, documents our code library to support this parallelization strategy, and presents a collection of tutorial example application programs

An Artificial Intelligence Approach to Detect Visual Field Progression in Glaucoma Based on Spatial Pattern Analysis.

Purpose: To detect visual field (VF) progression by analyzing spatial pattern changes. Methods: We selected 12,217 eyes from 7360 patients with at least five reliable 24-2 VFs and 5 years of follow-up with an interval of at least 6 months. VFs were decomposed into 16 archetype patterns previously derived by artificial intelligence techniques. Linear regressions were applied to the 16 archetype weights of VF series over time. We defined progression as the decrease rate of the normal archetype or any increase rate of the 15 VF defect archetypes to be outside normal limits. The archetype method was compared with mean deviation (MD) slope, Advanced Glaucoma Intervention Study (AGIS) scoring, Collaborative Initial Glaucoma Treatment Study (CIGTS) scoring, and the permutation of pointwise linear regression (PoPLR), and was validated by a subset of VFs assessed by three glaucoma specialists. Results: In the method development cohort of 11,817 eyes, the archetype method agreed more with MD slope (kappa: 0.37) and PoPLR (0.33) than AGIS (0.12) and CIGTS (0.22). The most frequently progressed patterns included decreased normal pattern (63.7%), and increased nasal steps (16.4%), altitudinal loss (15.9%), superior-peripheral defect (12.1%), paracentral/central defects (10.5%), and near total loss (10.4%). In the clinical validation cohort of 397 eyes with 27.5% of confirmed progression, the agreement (kappa) and accuracy (mean of hit rate and correct rejection rate) of the archetype method (0.51 and 0.77) significantly (P \u3c 0.001 for all) outperformed AGIS (0.06 and 0.52), CIGTS (0.24 and 0.59), MD slope (0.21 and 0.59), and PoPLR (0.26 and 0.60). Conclusions: The archetype method can inform clinicians of VF progression patterns

Unicity of types for supercuspidal representations of p-adic SL2

We consider the question of unicity of types on maximal compact subgroups for supercuspidal representations of SL2 over a nonarchimedean local field of odd residual characteristic. We introduce the notion of an archetype as the SL2-conjugacy class of a typical representation of a maximal compact subgroup, and go on to show that any archetype in SL2 is restricted from one in GL2. From this it follows that any archetype must be induced from a Bushnell-Kutzko type. Given a supercuspidal representation π of SL2(F), we give an additional explicit description of the number of archetypes admitted by π in terms of its ramification. We also describe a relationship between archetypes for GL2 and SL2 in terms of L-packets, and deduce an inertial Langlands correspondence for SL2

EFFICIENT PROPAGATION OF ARCHETYPE JC POLYOMAVIRUS IN COS-7 CELLS: EVALUATION OF REARRANGEMENTS WITHIN NCCR STRUCTURAL ORGANIZATION DURING TRANSFECTION.

John Cunningham virus (JCPyV) is an ubiqui-tous human pathogen that causes disease in immunocom-promised patients. The JCPyV genome is composed of an early region and a late region, which are physically sepa-rated by the non-coding control region (NCCR). The DNA sequence of the NCCR distinguishes two forms of JCPyV, the designated archetype and the prototype, which resulted from a rearrangement of the archetype sequence. To date, the cell culture systems for propagating JCPyV archetype have been very limited in their availability and robust-ness. Prior to this study, it was demonstrated that JCPyV archetype DNA replicates in COS-7 simian kidney cells expressing SV40 TAg and COS-7 cells expressing HIV-1 Tat. Based on these observations, the present study was conducted to reproduce an in vitro model in COS-7 cells transfected with the JCPyV archetype strain in order to study JCPyV DNA replication and analyze NCCR rear-rangements during the viral life cycle. The efficiency of JCPyV replication was evaluated by quantitative PCR (Q-PCR) and by hemagglutination (HA) assay after trans-fection. In parallel, sequence analysis of JCPyV NCCR was performed. JCPyV efficiently replicated in kidney-derived COS-7 cells, as demonstrated by a progressive increase in viral load and virion particle production after transfection. The archetypal structure of NCCR was maintained during the viral cycle, but two characteristic point mutations were detected 28 days after transfection. This model is a useful tool for analyzing NCCR rearrangements during in vitroreplication in cells that are sites of viral persistence, such as tubular epithelial cells of the kidne

Socrates and the Story of Inquiry

Argument and myth, historical figure and archetype, Socrates dominates our image of inquiry. How did this come about and should it continue

Innate and Emergent: Jung, Yoga and the Archetype of the Self Encounter the Objective Measures of Affective Neuroscience

Jung’s individuation process, the central process of human development, relies heavily on several core philosophical and psychological ideas including the unconscious, complexes, the archetype of the Self, and the religious function of the psyche. While working to find empirical evidence of the psyche’s religious function, Jung studied a variety of subjects including the Eastern liberatory traditions of Buddhism and Patañjali’s Classical Yoga. In these traditions, Jung found substantiation of his ideas on psychospiritual development. Although Jung’s career in soul work was lengthy, throughout, he aimed to steer clear of metaphysics. Patañjali’s metaphysics, on the other hand, are straightforward, and his ontological commitments are evident. Because Jung’s ontological commitments were not explicit, his theories, when seen through Patañjali’s lens, confuse ontological questions with epistemic issues. As a result, when comparing the Jungian and Patañjalian notions of the Self, Jung’s insightful ideas seem to be constructed upon a considerably shaky foundation. Yet, utilizing the exceptionally consistent ontological and epistemological commitments of Patañjali Yoga, as well as the objective measures of affective neuroscience, brings credence to the innate aspects and instinctual nature of Jung’s archetype of the Self, and assists in answering the question of whether the archetype is innate or emergent

Peering into the Jezebel Archetype in African American Culture and Emancipating Her from Hyper-Sexuality: Within and Beyond James Baldwin’s \u27Go Tell It on the Mountain\u27 and Alice Walker’s \u27The Color Purple\u27

Literary authors and performing artists are redefining the image of the Jezebel archetype from a negative stereotype to an empowering persona. The reformation of the Jezebel’s identity and reputation, from a manipulating stereotype to an uplifting individual may not be a common occurrence, but the Jezebel archetype as a positive figure has earned a dignified position in literature and in reality. Jezebel archetypes wear their sexuality proudly. Her sultriness may be the first aspect of her identity that readers see, but readers must be cautious not to overlook her merit and moral standards as a character that has the potential to advance and mobilize her peers (within fiction and reality)