Prospects for Theranostics in Neurosurgical Imaging: Empowering Confocal Laser Endomicroscopy Diagnostics via Deep Learning

Confocal laser endomicroscopy (CLE) is an advanced optical fluorescence imaging technology that has the potential to increase intraoperative precision, extend resection, and tailor surgery for malignant invasive brain tumors because of its subcellular dimension resolution. Despite its promising diagnostic potential, interpreting the gray tone fluorescence images can be difficult for untrained users. In this review, we provide a detailed description of bioinformatical analysis methodology of CLE images that begins to assist the neurosurgeon and pathologist to rapidly connect on-the-fly intraoperative imaging, pathology, and surgical observation into a conclusionary system within the concept of theranostics. We present an overview and discuss deep learning models for automatic detection of the diagnostic CLE images and discuss various training regimes and ensemble modeling effect on the power of deep learning predictive models. Two major approaches reviewed in this paper include the models that can automatically classify CLE images into diagnostic/nondiagnostic, glioma/nonglioma, tumor/injury/normal categories and models that can localize histological features on the CLE images using weakly supervised methods. We also briefly review advances in the deep learning approaches used for CLE image analysis in other organs. Significant advances in speed and precision of automated diagnostic frame selection would augment the diagnostic potential of CLE, improve operative workflow and integration into brain tumor surgery. Such technology and bioinformatics analytics lend themselves to improved precision, personalization, and theranostics in brain tumor treatment.Comment: See the final version published in Frontiers in Oncology here: https://www.frontiersin.org/articles/10.3389/fonc.2018.00240/ful

Trialing project-based learning in a new EAP ESP course: A collaborative reflective practice of three college English teachers

Currently in many Chinese universities, the traditional College English course is facing the risk of being ‘marginalized’, replaced or even removed, and many hours previously allocated to the course are now being taken by EAP or ESP. At X University in northern China, a curriculum reform as such is taking place, as a result of which a new course has been created called ‘xue ke’ English. Despite the fact that ‘xue ke’ means subject literally, the course designer has made it clear that subject content is not the target, nor is the course the same as EAP or ESP. This curriculum initiative, while possibly having been justified with a rationale of some kind (e.g. to meet with changing social and/or academic needs of students and/or institutions), this is posing a great challenge for, as well as considerable pressure on, a number of College English teachers who have taught this single course for almost their entire teaching career. In such a context, three teachers formed a peer support group in Semester One this year, to work collaboratively co-tackling the challenge, and they chose Project-Based Learning (PBL) for the new course. This presentation will report on the implementation of this project, including the overall designing, operational procedure, and the teachers’ reflections. Based on discussion, pre-agreement was reached on the purpose and manner of collaboration as offering peer support for more effective teaching and learning and fulfilling and pleasant professional development. A WeChat group was set up as the chief platform for messaging, idea-sharing, and resource-exchanging. Physical meetings were supplementary, with sound agenda but flexible time, and venues. Mosoteach cloud class (lan mo yun ban ke) was established as a tool for virtual learning, employed both in and after class. Discussions were held at the beginning of the semester which determined only brief outlines for PBL implementation and allowed space for everyone to autonomously explore in their own way. Constant further discussions followed, which generated a great deal of opportunities for peer learning and lesson plan modifications. A reflective journal, in a greater or lesser detailed manner, was also kept by each teacher to record the journey of the collaboration. At the end of the semester, it was commonly recognized that, although challenges existed, the collaboration was overall a success and they were all willing to continue with it and endeavor to refine it to be a more professional and productive approach

Non-Invasive Ambient Intelligence in Real Life: Dealing with Noisy Patterns to Help Older People

This paper aims to contribute to the field of ambient intelligence from the perspective of real environments, where noise levels in datasets are significant, by showing how machine learning techniques can contribute to the knowledge creation, by promoting software sensors. The created knowledge can be actionable to develop features helping to deal with problems related to minimally labelled datasets. A case study is presented and analysed, looking to infer high-level rules, which can help to anticipate abnormal activities, and potential benefits of the integration of these technologies are discussed in this context. The contribution also aims to analyse the usage of the models for the transfer of knowledge when different sensors with different settings contribute to the noise levels. Finally, based on the authors’ experience, a framework proposal for creating valuable and aggregated knowledge is depicted.This research was partially funded by Fundación Tecnalia Research & Innovation, and J.O.-M. also wants to recognise the support obtained from the EU RFCS program through project number 793505 ‘4.0 Lean system integrating workers and processes (WISEST)’ and from the grant PRX18/00036 given by the Spanish Secretaría de Estado de Universidades, Investigación, Desarrollo e Innovación del Ministerio de Ciencia, Innovación y Universidades

Using webcrawling of publicly available websites to assess E-commerce relationships

We investigate e-commerce success factors concerning their impact on the success of commerce transactions between businesses companies. In scientific literature, many e-commerce success factors are introduced. Most of them are focused on companies' website quality. They are evaluated concerning companies' success in the business-to- consumer (B2C) environment where consumers choose their preferred e-commerce websites based on these success factors e.g. website content quality, website interaction, and website customization. In contrast to previous work, this research focuses on the usage of existing e-commerce success factors for predicting successfulness of business-to-business (B2B) ecommerce. The introduced methodology is based on the identification of semantic textual patterns representing success factors from the websites of B2B companies. The successfulness of the identified success factors in B2B ecommerce is evaluated by regression modeling. As a result, it is shown that some B2C e-commerce success factors also enable the predicting of B2B e-commerce success while others do not. This contributes to the existing literature concerning ecommerce success factors. Further, these findings are valuable for B2B e-commerce websites creation

Leveraging Mobile App Classification and User Context Information for Improving Recommendation Systems

Mobile apps play a significant role in current online environments where there is an overwhelming supply of information. Although mobile apps are part of our daily routine, searching and finding mobile apps is becoming a nontrivial task due to the current volume, velocity and variety of information. Therefore, app recommender systems provide users’ desired apps based on their preferences. However, current recommender systems and their underlying techniques are limited in effectively leveraging app classification schemes and context information. In this thesis, I attempt to address this gap by proposing a text analytics framework for mobile app recommendation by leveraging an app classification scheme that incorporates the needs of users as well as the complexity of the user-item-context information in mobile app usage pattern. In this recommendation framework, I adopt and empirically test an app classification scheme based on textual information about mobile apps using data from Google Play store. In addition, I demonstrate how context information such as user social media status can be matched with app classification categories using tree-based and rule-based prediction algorithms. Methodology wise, my research attempts to show the feasibility of textual data analysis in profiling apps based on app descriptions and other structured attributes, as well as explore mechanisms for matching user preferences and context information with app usage categories. Practically, the proposed text analytics framework can allow app developers reach a wider usage base through better understanding of user motivation and context information