1,257 research outputs found
Bits from Biology for Computational Intelligence
Computational intelligence is broadly defined as biologically-inspired
computing. Usually, inspiration is drawn from neural systems. This article
shows how to analyze neural systems using information theory to obtain
constraints that help identify the algorithms run by such systems and the
information they represent. Algorithms and representations identified
information-theoretically may then guide the design of biologically inspired
computing systems (BICS). The material covered includes the necessary
introduction to information theory and the estimation of information theoretic
quantities from neural data. We then show how to analyze the information
encoded in a system about its environment, and also discuss recent
methodological developments on the question of how much information each agent
carries about the environment either uniquely, or redundantly or
synergistically together with others. Last, we introduce the framework of local
information dynamics, where information processing is decomposed into component
processes of information storage, transfer, and modification -- locally in
space and time. We close by discussing example applications of these measures
to neural data and other complex systems
Multivariate Granger Causality and Generalized Variance
Granger causality analysis is a popular method for inference on directed
interactions in complex systems of many variables. A shortcoming of the
standard framework for Granger causality is that it only allows for examination
of interactions between single (univariate) variables within a system, perhaps
conditioned on other variables. However, interactions do not necessarily take
place between single variables, but may occur among groups, or "ensembles", of
variables. In this study we establish a principled framework for Granger
causality in the context of causal interactions among two or more multivariate
sets of variables. Building on Geweke's seminal 1982 work, we offer new
justifications for one particular form of multivariate Granger causality based
on the generalized variances of residual errors. Taken together, our results
support a comprehensive and theoretically consistent extension of Granger
causality to the multivariate case. Treated individually, they highlight
several specific advantages of the generalized variance measure, which we
illustrate using applications in neuroscience as an example. We further show
how the measure can be used to define "partial" Granger causality in the
multivariate context and we also motivate reformulations of "causal density"
and "Granger autonomy". Our results are directly applicable to experimental
data and promise to reveal new types of functional relations in complex
systems, neural and otherwise.Comment: added 1 reference, minor change to discussion, typos corrected; 28
pages, 3 figures, 1 table, LaTe
Dynamic imaging of coherent sources reveals different network connectivity underlying the generation and perpetuation of epileptic seizures
The concept of focal epilepsies includes a seizure origin in brain regions with hyper synchronous activity (epileptogenic zone and seizure onset zone) and a complex epileptic network of different brain areas involved in the generation, propagation, and modulation of seizures. The purpose of this work was to study functional and effective connectivity between regions involved in networks of epileptic seizures. The beginning and middle part of focal seizures from ictal surface EEG data were analyzed using dynamic imaging of coherent sources (DICS), an inverse solution in the frequency domain which describes neuronal networks and coherences of oscillatory brain activities. The information flow (effective connectivity) between coherent sources was investigated using the renormalized partial directed coherence (RPDC) method. In 8/11 patients, the first and second source of epileptic activity as found by DICS were concordant with the operative resection site; these patients became seizure free after epilepsy surgery. In the remaining 3 patients, the results of DICS / RPDC calculations and the resection site were discordant; these patients had a poorer post-operative outcome. The first sources as found by DICS were located predominantly in cortical structures; subsequent sources included some subcortical structures: thalamus, Nucl. Subthalamicus and cerebellum. DICS seems to be a powerful tool to define the seizure onset zone and the epileptic networks involved. Seizure generation seems to be related to the propagation of epileptic activity from the primary source in the seizure onset zone, and maintenance of seizures is attributed to the perpetuation of epileptic activity between nodes in the epileptic network. Despite of these promising results, this proof of principle study needs further confirmation prior to the use of the described methods in the clinical praxis
Graph analysis of functional brain networks: practical issues in translational neuroscience
The brain can be regarded as a network: a connected system where nodes, or
units, represent different specialized regions and links, or connections,
represent communication pathways. From a functional perspective communication
is coded by temporal dependence between the activities of different brain
areas. In the last decade, the abstract representation of the brain as a graph
has allowed to visualize functional brain networks and describe their
non-trivial topological properties in a compact and objective way. Nowadays,
the use of graph analysis in translational neuroscience has become essential to
quantify brain dysfunctions in terms of aberrant reconfiguration of functional
brain networks. Despite its evident impact, graph analysis of functional brain
networks is not a simple toolbox that can be blindly applied to brain signals.
On the one hand, it requires a know-how of all the methodological steps of the
processing pipeline that manipulates the input brain signals and extract the
functional network properties. On the other hand, a knowledge of the neural
phenomenon under study is required to perform physiological-relevant analysis.
The aim of this review is to provide practical indications to make sense of
brain network analysis and contrast counterproductive attitudes
Macaque's Cortical Functional Connectivity Dynamics at the Onset of Propofol-Induced Anesthesia
Propofol, when administered for general anesthesia, induces oscillatory
dynamic brain states that are thought to underlie the drug's pharmacological
effects. Despite the elucidation of propofol's mechanisms of action at the
molecular level, its effects on neural circuits and overall cortical
functioning, which eventually lead to unconsciousness, are still unclear. To
identify possible mechanisms, the spatial-temporal patterns of functional
connectivity established among specialized cortical areas in anesthetized
subjects need to be described. Within this context, the present research
involved the analysis of dense sub-dural ECoG electrode array recordings from
macaques under propofol anesthetic induction. Granger causality methodology was
used to infer functional connectivity interactions in five physiological
frequency bands serially over time, every five seconds throughout the
experiment. The time-resolved networks obtained permitted us to observe the
unfolding of the anesthetic induction and compare the networks obtained under
different experimental conditions. About one minute after administering
propofol, functional connectivity started to increase for 4-5 minutes, then
decreased until the LOC was achieved. A predominant Granger causality flow from
the occipital and temporal areas towards the frontal and parietal regions was
also evidenced during the transition. During general anesthesia, the local
connectivity of the occipital lobe increased, as did the interactions between
the occipital and temporal lobes. Conversely, the functional connectivity from
the frontal and parietal lobes toward the temporal and occipital regions was
mainly impaired. The research is one of the first studies to describe the
dynamics of the functional connectivity during the transitional state that
precedes the LOC.Comment: 20 pages, 5 figure
Assessing the strength of directed influences among neural signals : An approach to noisy data
Acknowledgements This work was supported by the German Science Foundation (Ti315/4-2), the German Federal Ministry of Education and Research (BMBF grant 01GQ0420), and the Excellence Initiative of the German Federal and State Governments. B.S. is indebted to the Kosterlitz Centre for the financial support of this research project.Peer reviewedPreprin
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