Genetic algorithm based two-mode clustering of metabolomics data

Metabolomics and other omics tools are generally characterized by large data sets with many variables obtained under different environmental conditions. Clustering methods and more specifically two-mode clustering methods are excellent tools for analyzing this type of data. Two-mode clustering methods allow for analysis of the behavior of subsets of metabolites under different experimental conditions. In addition, the results are easily visualized. In this paper we introduce a two-mode clustering method based on a genetic algorithm that uses a criterion that searches for homogeneous clusters. Furthermore we introduce a cluster stability criterion to validate the clusters and we provide an extended knee plot to select the optimal number of clusters in both experimental and metabolite modes. The genetic algorithm-based two-mode clustering gave biological relevant results when it was applied to two real life metabolomics data sets. It was, for instance, able to identify a catabolic pathway for growth on several of the carbon sources

Traffic Offloading/Onloading in Multi-RAT Cellular Networks

We analyze next generation cellular networks, offering connectivity to mobile users through multiple radio access technologies (RATs), namely LTE and WiFi. We develop a framework based on the Markovian agent formalism, which can model several aspects of the system, including user traffic dynamics and radio resource allocation. In particular, through a mean-field solution, we show the ability of our framework to capture the system behavior in flash-crowd scenarios, i.e., when a burst of traffic requests takes place in some parts of the network service area. We consider a distributed strategy for the user RAT selection, which aims at ensuring high user throughput, and investigate its performance under different resource allocation scheme

Multiobjective auction-based switching-off scheme in heterogeneous networks: to bid or not to bid?

©2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.The emerging data traffic demand has caused a massive deployment of network infrastructure, including Base Stations (BSs) and Small Cells (SCs), leading to increased energy consumption and expenditures. However, the network underutilization during low traffic periods enables the Mobile Network Operators (MNOs) to save energy by having their traffic served by third party SCs, thus being able to switch off their BSs. In this paper, we propose a novel market approach to foster the opportunistic utilization of the unexploited SCs capacity, where the MNOs, instead of requesting the maximum capacity to meet their highest traffic expectations, offer a set of bids requesting different resources from the third party SCs at lower costs. Motivated by the conflicting financial interests of the MNOs and the third party, the restricted capacity of the SCs that is not adequate to carry the whole traffic in multi-operator scenarios, and the necessity for energy efficient solutions, we introduce a combinatorial auction framework, which includes i) a bidding strategy, ii) a resource allocation scheme, and iii) a pricing rule. We propose a multiobjective framework as an energy and cost efficient solution for the resource allocation problem, and we provide extensive analytical and experimental results to estimate the potential energy and cost savings that can be achieved. In addition, we investigate the conditions under which the MNOs and the third party companies should take part in the proposed auction.Peer ReviewedPostprint (author's final draft

Modeling of fibrous biological tissues with a general invariant that excludes compressed fibers

Dispersed collagen fibers in fibrous soft biological tissues have a significant effect on the overall mechanical behavior of the tissues. Constitutive modeling of the detailed structure obtained by using advanced imaging modalities has been investigated extensively in the last decade. In particular, our group has previously proposed a fiber dispersion model based on a generalized structure tensor. However, the fiber tension–compression switch described in that study is unable to exclude compressed fibers within a dispersion and the model requires modification so as to avoid some unphysical effects. In a recent paper we have proposed a method which avoids such problems, but in this present study we introduce an alternative approach by using a new general invariant that only depends on the fibers under tension so that compressed fibers within a dispersion do not contribute to the strain-energy function. We then provide expressions for the associated Cauchy stress and elasticity tensors in a decoupled form. We have also implemented the proposed model in a finite element analysis program and illustrated the implementation with three representative examples: simple tension and compression, simple shear, and unconfined compression on articular cartilage. We have obtained very good agreement with the analytical solutions that are available for the first two examples. The third example shows the efficacy of the fibrous tissue model in a larger scale simulation. For comparison we also provide results for the three examples with the compressed fibers included, and the results are completely different. If the distribution of collagen fibers is such that it is appropriate to exclude compressed fibers then such a model should be adopted

T-WAS and T-XAS algorithms for fiber-loop optical buffers

In optical packet/burst switched networks fiber loops provide a viable and compact means of contention resolution. For fixed size packets it is known that a basic void-avoiding schedule (VAS) can vastly outperform a more classical pre-reservation algorithm as FCFS. For the setting of a uniform distributed packet size and a restricted buffer size we proposed two novel forward-looking algorithms, WAS and XAS, that, in specific settings, outperform VAS up to 20% in terms of packet loss. This contribution extends the usage and improves the performance of the WAS and XAS algorithms by introducing an additional threshold variable. By optimizing this threshold, the process of selectively delaying packet longer than strictly necessary can be made more or less strict and as such be fitted to each setting. By Monte Carlo simulation it is shown that the resulting T-WAS and T-XAS algorithms are most effective for those instances where the algorithms without threshold can offer no or only limited performance improvement