Numerical simulation of time-dependent non-Newtonian nano-pharmacodynamic transport phenomena in a tapered overlapping stenosed artery

Nanofluids are becoming increasingly popular in novel hematological treatments and also advanced nanoscale biomedical devices. Motivated by recent developments in this area, a theoretical and numerical study is described for unsteady pulsatile flow, heat and mass transport through a tapered stenosed artery in the presence of nanoparticles. An appropriate geometric expression is employed to simulate the overlapping stenosed arterial segment. The Sisko non-Newtonian model is employed for hemodynamic rheology. Buongiorno’s formulation is employed to model nanoscale effects. The two-dimensional non-linear, coupled equations are simplified for the case of mild stenosis. An explicit forward time central space (FTCS) finite difference scheme is employed to obtain a numerical solution of these equations. Validation of the computations is achieved with another numerical method, namely the variational finite element method (FEM). The effects of various emerging rheological, nanoscale and thermofluid parameters on flow and heat/mass characteristics of blood are shown via several plots and discussed in detail. The circulating regions inside the flow field are also investigated through instantaneous patterns of streamlines. The work is relevant to nanopharmacological transport phenomena, a new and exciting area of modern medical fluid dynamics which integrates coupled diffusion, viscous flow and nanoscale drug delivery mechanisms

Comparative Analysis of Mathematical Models for Blood Flow in Tapered Constricted Arteries

Pulsatile flow of blood in narrow tapered arteries with mild overlapping stenosis in the presence of periodic body acceleration is analyzed mathematically, treating it as two-fluid model with the suspension of all the erythrocytes in the core region as non-Newtonian fluid with yield stress and the plasma in the peripheral layer region as Newtonian. The non-Newtonian fluid with yield stress in the core region is assumed as �i� Herschel-Bulkley fluid and �ii� Casson fluid. The expressions for the shear stress, velocity, flow rate, wall shear stress, plug core radius, and longitudinal impedance to flow obtained by Sankar �2010� for two-fluidHerschel-Bulkleymodel and Sankar and Lee �2011� for two-fluid Casson model are used to compute the data for comparing these fluid models. It is observed that the plug core radius, wall shear stress, and longitudinal impedance to flow are lower for the two-fluid H-B model compared to the corresponding flow quantities of the two-fluid Casson model. It is noted that the plug core radius and longitudinal impedance to flow increases with the increase of the maximum depth of the stenosis. The mean velocity and mean flow rate of two-fluid H-B model are higher than those of the two-fluid Casson model

A Two-layered Non-Newtonian Arterial Blood Flow through an Overlapping Constriction

The problem of blood flow through an overlapping constriction in arteries is investigated in this work. To account for the non-Newtonian behavior and the peripheral layer, blood has been represented by a two-fluid model, consisting of a core region of suspension of all the erythrocytes assumed to be a Casson fluid and a peripheral layer of plasma (Newtonian fluid). The expression for the flow characteristics, namely, the impedance, the wall shear stress, the shear stress at the stenosis throats and at the critical height of the stenosis has been derived. Moreover, we present some results concerning the dependence of these quantities on the geometrical parameters

Non-Newtonian Arterial Blood Flow through an Overlapping Stenosis

The effects of an overlapping stenosis on blood flow characteristics in a narrow artery have been investigated. To account for the non-Newtonian behavior, blood has been represented by a Casson fluid. The equation describing the flow has been solved and the expressions for the flow characteristics, namely, the impedance, the wall shear stress, the shear stress at the stenosis throats and the shear stress at the critical height of the stenosis have been derived. It is shown that the impedance increases with the non-Newtonian behavior of blood as well as with the stenosis size. The shear stress at the stenosis two throats assumes the same magnitude. The shear stress at the stenosis critical height assumes significantly lower magnitude than its corresponding value at the throats. With respect to any given parameter, the nature of the variations of shear stresses at the throats and at the critical height of the stenosis is similar to that of the flow resistance

Mathematical Model of Blood Flow through a Composite Stenosis in Catheterized Artery with Permeable Wall

The present mathematical analysis, the study of blood flow through the model of a composite stenosed catheterized artery with permeable wall, has been performed to investigate the blood flow characteristics. The expressions for the blood flow characteristics-the impedance (resistance to flow), the wall shear stress distribution in stenosis region, the shear stress at the throat of the stenosis have been derived. The results obtained are displayed graphically and discussed briefly

Unsteady two-layered blood flow through a w-shape stenosed artery using the generalized oldroyd-b fluid model

A theoretical study of unsteady two-layered blood flow through a stenosed artery is presented in this article. The geometry of rigid stenosed artery is assumed to be w-shaped. The flow regime is assumed to be laminar, unsteady and uni-directional. The characteristics of blood are modeled by the generalized Oldroyd-B non-Newtonian fluid model in the core region and a Newtonian fluid in the periphery region. The governing partial differential are derived for each region by using mass and momentum conservation equations. In order to facilitate numerical solutions, the derived differential equations are non-dimensionalized. A well-tested explicit finite difference scheme (FDM) which is forward in time and central in space is employed for the solution of nonlinear initial-boundary value problem corresponding to each region. Validation of the FDM computations is achieved with a variational finite element method (FEM) algorithm. The influence of the emerging geometric and rheological parameters on axial velocity, resistance impedance and wall shear stress are displayed graphically. The instantaneous patterns of streamlines are also presented to illustrate the global behavior of blood flow. The simulations are relevant to hemodynamics of small blood vessels and capillary transport wherein rheological effects are dominant

Mathematical Analysis of Carreau Fluid model for Blood Flow in Tapered Constricted Arteries

The pulsatile flow of blood through a tapered constricted narrow artery is investigated in this study, treating the blood as Carreau fluid model. The constriction in the artery is due to the formation of asymmetric stenosis in the lumen of the artery. The expressions obtained by Sankar (2016) for the various flow quantities are used to analyze the flow with different arterial geometry. The influence of various flow parameters on the velocity distribution, wall shear stress and longitudinal impedance to flow is discussed. The velocity of blood increases with the increase of the power law index and stenosis shape parameter and it decreases considerably with the increase of the maximum depth of the stenosis. The wall shear stress and longitudinal impedance to flow decrease with the increase stenosis shape parameter, amplitude of the pulsatile pressure gradient, flow rate, power law index and Weissenberg number. The estimates of the percentage of increase in the wall shear stress and longitudinal impedance to flow increase with the increase of the angle tapering and these increase significantly with the increase of the maximum depth of the stenosis. The mean velocity of blood decreases considerably with the increase of the artery radius (except in arteriole), maximum depth of the stenosis and angle of tapering and it is considerably higher in pulsatile flow of blood than in the steady flow of blood

Particulate Suspension Blood Flow through a Stenosed Catheterized Artery

The flow of blood through a narrow catheterized artery with an overlapping stenosis has been investigated. To account for the presence of red cells, blood has been represented by a macroscopic two-phase model (i.e., a suspension of erythrocytes in plasma). The expression for the flow characteristics-the flow rate, the impedance (resistance to flow), the wall shear stress in the stenotic region, the shear stresses at the stenosis two throats and at critical height of the stenosis, has been derived. It is found that the impedance increases with the catheter size, with the hematocrit and also with the stenosis size (height and length). A significant increase in the magnitude of the impedance and other flow characteristics occur even for a small increase in the catheter size. Variations in the magnitude of all the flow characteristics are observed to be similar in nature with respect to any parameter given

Blood Flow through a Composite Stenosis in an Artery with Permeable Wall

The present work concerns the fluid mechanical study on the effects of the permeability of the wall through an artery with a composite stenosis. The expressions for the blood flow characteristics, the flow resistance, the wall shear stress, shearing stress at the stenosis throat have been derived. Results for the effect of permeability on these flow characteristics are shown graphically and discussed briefly

A Macroscopic Two-Phase Blood Flow through a Bell Shaped Stenosis in an Artery with Permeable Wall

The present work concerns the effects of the hematocrit and the permeability of the wall on blood flow characteristics due to the presence of a bell shaped stenosis in an artery. In this analysis, the flowing blood is represented by a macroscopic two-phase model, as a suspension of erythrocytes in plasma. The analytical expressions for the flow characteristics, namely, the flow resistance (impedance), the wall shear stress distribution in the stenotic region and the shearing stress at the stenosis throat have been derived. Results for the effects of permeability as well as of hematocrit on these flow characteristics are shown graphically and discussed briefly