Analysis of cross-correlations in electroencephalogram signals as an approach to proactive diagnosis of schizophrenia

We apply flicker-noise spectroscopy (FNS), a time series analysis method operating on structure functions and power spectrum estimates, to study the clinical electroencephalogram (EEG) signals recorded in children/adolescents (11 to 14 years of age) with diagnosed schizophrenia-spectrum symptoms at the National Center for Psychiatric Health (NCPH) of the Russian Academy of Medical Sciences. The EEG signals for these subjects were compared with the signals for a control sample of chronically depressed children/adolescents. The purpose of the study is to look for diagnostic signs of subjects' susceptibility to schizophrenia in the FNS parameters for specific electrodes and cross-correlations between the signals simultaneously measured at different points on the scalp. Our analysis of EEG signals from scalp-mounted electrodes at locations F3 and F4, which are symmetrically positioned in the left and right frontal areas of cerebral cortex, respectively, demonstrates an essential role of frequency-phase synchronization, a phenomenon representing specific correlations between the characteristic frequencies and phases of excitations in the brain. We introduce quantitative measures of frequency-phase synchronization and systematize the values of FNS parameters for the EEG data. The comparison of our results with the medical diagnoses for 84 subjects performed at NCPH makes it possible to group the EEG signals into 4 categories corresponding to different risk levels of subjects' susceptibility to schizophrenia. We suggest that the introduced quantitative characteristics and classification of cross-correlations may be used for the diagnosis of schizophrenia at the early stages of its development.Comment: 36 pages, 6 figures, 2 tables; to be published in "Physica A

Chasing 'Slow Light'

A critical review of experimental studies of the so-called 'slow light' arising due to anomalously high steepness of the refractive index dispersion under conditions of electromagnetically induced transparency or coherent population oscillations is presented. It is shown that a considerable amount of experimental evidence for observation of the 'slow light' is not related to the low group velocity of light and can be easily interpreted in terms of a standard model of interaction of light with a saturable absorber.Comment: 17 pages, 8 figures, to be published in June issue of Phisics: Uspekhi under the title "Notes on Slow Light

Unraveling the dynamics of growth, aging and inflation for citations to scientific articles from specific research fields

We analyze the time evolution of citations acquired by articles from journals of the American Physical Society (PRA, PRB, PRC, PRD, PRE and PRL). The observed change over time in the number of papers published in each journal is considered an exogenously caused variation in citability that is accounted for by a normalization. The appropriately inflation-adjusted citation rates are found to be separable into a preferential-attachment-type growth kernel and a purely obsolescence-related (i.e., monotonously decreasing as a function of time since publication) aging function. Variations in the empirically extracted parameters of the growth kernels and aging functions associated with different journals point to research-field-specific characteristics of citation intensity and knowledge flow. Comparison with analogous results for the citation dynamics of technology-disaggregated cohorts of patents provides deeper insight into the basic principles of information propagation as indicated by citing behavior.Comment: 13 pages, 6 figures, Elsevier style, v2: revised version to appear in J. Informetric

The comparison of characteristics of pi^{-} mesons produced in central Mg-Mg interactions with the quark gluon string model predictions

A detailed study of pion production in central Mg-Mg collisions at a momentum of 4.3 GeV/c per incident nucleon was carried out with use of the setup GIBS. The average kinematical characteristics of pions (multiplicity n_, momentum P, transverse momentum P_{T}, emission angle Q, rapidity Y) and corresponding distributions have been obtained. The experimental results have been compared with the predictions of the Quark Gluon String Model (QGSM) and satisfactory agreement between the experimental data and the model has been found. The QGSM reproduces also the dependence of average P_{T} on n_{-}. The temperatures of pi^{-} mesons have been estimated in the rapidity interval of 0.5<=Y<=2.1. A satisfactory fit for pi^{-} mesons has been achieved by using a form involving two temperatures T_{1} and T_{2}. It was found that the QGSM underestimates T_{2} by (10-15)%. The data have been analyzed using the transverse momentum technique. The observed dependence of the on Y shows the S-shape behaviour. The slope at midrapidity F had been determined. The QGSM reproduces the distribution satisfactorily, but underestimates the parameter F.Comment: 21 pages with 9 postscript figure

Flow probe of symmetry energy in relativistic heavy-ion reactions

Flow observables in heavy-ion reactions at incident energies up to about 1 GeV per nucleon have been shown to be very useful for investigating the reaction dynamics and for determining the parameters of reaction models based on transport theory. In particular, the elliptic flow in collisions of neutron-rich heavy-ion systems emerges as an observable sensitive to the strength of the symmetry energy at supra-saturation densities. The comparison of ratios or differences of neutron and proton flows or neutron and hydrogen flows with predictions of transport models favors an approximately linear density dependence, consistent with ab-initio nuclear-matter theories. Extensive parameter searches have shown that the model dependence is comparable to the uncertainties of existing experimental data. Comprehensive new flow data of high accuracy, partly also through providing stronger constraints on model parameters, can thus be expected to improve our knowledge of the equation of state of asymmetric nuclear matter.Comment: 20 pages, 24 figures, review to appear in EPJA special volume on nuclear symmetry energ

Statistical inference of the mechanisms driving collective cell movement

Numerous biological processes, many impacting on human health, rely on collective cell movement. We develop nine candidate models, based on advection-diffusion partial differential equations, to describe various alternative mechanisms that may drive cell movement. The parameters of these models were inferred from one-dimensional projections of laboratory observations of Dictyostelium discoideum cells by sampling from the posterior distribution using the delayed rejection adaptive Metropolis algorithm (DRAM). The best model was selected using the Widely Applicable Information Criterion (WAIC). We conclude that cell movement in our study system was driven both by a self-generated gradient in an attractant that the cells could deplete locally, and by chemical interactions between the cells

Recommended isolated-line profile for representing high-resolution spectroscopic transitions (IUPAC Technical Report)

The report of an IUPAC Task Group, formed in 2011 on "Intensities and line shapes in high-resolution spectra of water isotopologues from experiment and theory" (Project No. 2011-022-2-100), on line profiles of isolated high-resolution rotational-vibrational transitions perturbed by neutral gas-phase molecules is presented. The well-documented inadequacies of the Voigt profile (VP), used almost universally by databases and radiative-transfer codes, to represent pressure effects and Doppler broadening in isolated vibrational-rotational and pure rotational transitions of the water molecule have resulted in the development of a variety of alternative line-profile models. These models capture more of the physics of the influence of pressure on line shapes but, in general, at the price of greater complexity. The Task Group recommends that the partially Correlated quadratic-Speed-Dependent Hard-Collision profile should be adopted as the appropriate model for high-resolution spectroscopy. For simplicity this should be called the Hartmann--Tran profile (HTP). The HTP is sophisticated enough to capture the various collisional contributions to the isolated line shape, can be computed in a straightforward and rapid manner, and reduces to simpler profiles, including the Voigt profile, under certain simplifying assumptions.Comment: Accepted for publication in Pure and Applied Chemistr

Transformation of amorphous carbon clusters to fullerenes

Transformation of amorphous carbon clusters into fullerenes under high temperature is studied using molecular dynamics simulations at microsecond times. Based on the analysis of both structure and energy of the system, it is found that fullerene formation occurs in two stages. Firstly, fast transformation of the initial amorphous structure into a hollow sp$^2$ shell with a few chains attached occurs with a considerable decrease of the potential energy and the number of atoms belonging to chains and to the amorphous domain. Then, insertion of remaining carbon chains into the sp$^2$ network takes place at the same time with the fullerene shell formation. Two types of defects remaining after the formation of the fullerene shell are revealed: 7-membered rings and single one-coordinated atoms. One of the fullerene structures obtained contains no defects at all, which demonstrates that defect-free carbon cages can be occasionally formed from amorphous precursors directly without defect healing. No structural changes are observed after the fullerene formation, suggesting that defect healing is a slow process in comparison with the fullerene shell formation. The schemes of the revealed reactions of chain atoms insertion into the fullerene shell just before its completion are presented. The results of the performed simulations are summarized within the paradigm of fullerene formation due to selforganization of the carbon system.Comment: 35 pages, 9 figure