Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Linking an integrated framework with appropriate methods for measuring QoE

Quality of Experience (QoE) has recently gained recognition for being an important determinant of the success of new technologies. Despite the growing interest in QoE, research into this area is still fragmented. Similar - but separate - efforts are being carried out in technical as well as user oriented research domains, which are rarely communicating with each other. In this paper, we take a multidisciplinary approach and review both user oriented and technical definitions on Quality of Experience (including the related concept of User Experience). We propose a detailed and comprehensive framework that integrates both perspectives. Finally, we take a first step at linking methods for measuring QoE with this framework

An Iterative and Toolchain-Based Approach to Automate Scanning and Mapping Computer Networks

As today's organizational computer networks are ever evolving and becoming more and more complex, finding potential vulnerabilities and conducting security audits has become a crucial element in securing these networks. The first step in auditing a network is reconnaissance by mapping it to get a comprehensive overview over its structure. The growing complexity, however, makes this task increasingly effortful, even more as mapping (instead of plain scanning), presently, still involves a lot of manual work. Therefore, the concept proposed in this paper automates the scanning and mapping of unknown and non-cooperative computer networks in order to find security weaknesses or verify access controls. It further helps to conduct audits by allowing comparing documented with actual networks and finding unauthorized network devices, as well as evaluating access control methods by conducting delta scans. It uses a novel approach of augmenting data from iteratively chained existing scanning tools with context, using genuine analytics modules to allow assessing a network's topology instead of just generating a list of scanned devices. It further contains a visualization model that provides a clear, lucid topology map and a special graph for comparative analysis. The goal is to provide maximum insight with a minimum of a priori knowledge.Comment: 7 pages, 6 figure

An Ontology for Product-Service Systems

Industries are transforming their business strategy from a product-centric to a more service-centric nature by bundling products and services into integrated solutions to enhance the relationship between their customers. Since Product- Service Systems design research is currently at a rudimentary stage, the development of a robust ontology for this area would be helpful. The advantages of a standardized ontology are that it could help researchers and practitioners to communicate their views without ambiguity and thus encourage the conception and implementation of useful methods and tools. In this paper, an initial structure of a PSS ontology from the design perspective is proposed and evaluated

Scope, Scale, and Sustainability: What It Takes to Create Lasting Community Change

· This article examines success factors that relate specifically to the ability of a comprehensive community initiative (CCI) to achieve the scope and scale required to generate community-level outcomes and to sustain those positive impacts over time. · The CCIs selected for study represent a wide range of goals, strategies, and organizational structures. · Six factors were found to cut across scope, scale, and sustainability. These factors include having a single broker or entity that holds the vision of the change effort; clearly defined roles; alignment among interventions, resources, and geography; meaningful community engagement; competent leadership and staff; and strategic, cross-level relationships. · Additional factors were found to relate to success in achieving scope, scale, or sustainability individually. · Lessons include to plan, operate, and evaluate based on a systems- and community-change framework; choose focused and affordable strategies; build the capacity to use data; and plan for change and conflict