Cardiac Arrhythmias

The most intimate mechanisms of cardiac arrhythmias are still quite unknown to scientists. Genetic studies on ionic alterations, the electrocardiographic features of cardiac rhythm and an arsenal of diagnostic tests have done more in the last five years than in all the history of cardiology. Similarly, therapy to prevent or cure such diseases is growing rapidly day by day. In this book the reader will be able to see with brighter light some of these intimate mechanisms of production, as well as cutting-edge therapies to date. Genetic studies, electrophysiological and electrocardiographyc features, ion channel alterations, heart diseases still unknown , and even the relationship between the psychic sphere and the heart have been exposed in this book. It deserves to be read

Epilepsy

Epilepsy is the most common neurological disorder globally, affecting approximately 50 million people of all ages. It is one of the oldest diseases described in literature from remote ancient civilizations 2000-3000 years ago. Despite its long history and wide spread, epilepsy is still surrounded by myth and prejudice, which can only be overcome with great difficulty. The term epilepsy is derived from the Greek verb epilambanein, which by itself means to be seized and to be overwhelmed by surprise or attack. Therefore, epilepsy is a condition of getting over, seized, or attacked. The twelve very interesting chapters of this book cover various aspects of epileptology from the history and milestones of epilepsy as a disease entity, to the most recent advances in understanding and diagnosing epilepsy

Topics in Neuromodulation Treatment

"Topics in Neuromodulation Treatment" is a book that invites to the reader to make an update in this important and well-defined area involved in the Neuroscience world. The book pays attention in some aspects of the electrical therapy and also in the drug delivery management of several neurological illnesses including the classic ones like epilepsy, Parkinson's disease, pain, and other indications more recently incorporated to this important tool like bladder incontinency, heart ischemia and stroke. The manuscript is dedicated not only to the expert, but also to the scientist that begins in this amazing field. The authors are physicians of different specialties and they guarantee the clinical expertise to provide to the reader the best guide to treat the patient

Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon

copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND.Final Published versio

Psychology

Psychology is designed to meet scope and sequence requirements for the single-semester introduction to psychology course. The book offers a comprehensive treatment of core concepts, grounded in both classic studies and current and emerging research. The text also includes coverage of the DSM-5 in examinations of psychological disorders. Psychology incorporates discussions that reflect the diversity within the discipline, as well as the diversity of cultures and communities across the globe.https://commons.erau.edu/oer-textbook/1000/thumbnail.jp

Regional Cerebral Blood Flow in Focal Epilepsy

The first systematic documentation of dynamic cerebral vascular changes associated with focal seizures was made by Penfield in the thirties. In recent years in vivo imaging techniques, principally single photon emission computed tomography (SPECT), have been used to study regional cerebral blood flow (rCBF) in patients with focal epilepsy. The main finding has been of focal hypoperfusion, the location in the brain differing according to the site of the focus. The incidence and clinical associations of this finding have varied, and few large studies have been carried out. Until the development of the blood flow tracer HMPAO (hexamethylpropyleneamine oxime) there was no practical way to study regional cerebral blood flow during or soon after seizures. When the present work was started no studies existed, although several have appeared during its course. Only complex partial seizures of temporal lobe origin have been systematically studied

The effects of genes, antiepileptic drugs and risk of death on functional anatomy and cognitive networks in epilepsy

Epilepsy is one of the most common neurological disorders. Apart from seizures, patients are also affected by epilepsy comorbidities, such as cognitive impairment, side effects of antiepileptic drugs, and an increased risk of dying from sudden death. Within epilepsy research, recent efforts have been made to identify reliable biomarkers to advance the understanding of disease-mechanisms, to individualize and optimize treatment and side-effect profiles and to enhance prediction of treatment success and disease progression. Biomarkers are objective measures of a normal or pathological biological process and, in the context of this PhD, neuroimaging biomarkers ideally enable in vivo measurements of (i) disease activity, (ii) treatment effects and (iii) risk of comorbidities and mortality. Employing functional and structural neuroimaging techniques, we studied potential neuroimaging biomarkers in three different domains of epilepsy. In the first project, we explored fMRI endophenotypes in a prototype of a genetic generalised epilepsy syndrome, namely juvenile myoclonic epilepsy (JME). Endophenotypes are heritable traits, closer related to the genotype than the final phenotype and are found frequently in non-affected family members of patients. Our study revealed potential functional endophenotypes and support a genetically determined neurodevelopmental disease mechanism in JME. The second project investigated fMRI markers of antiepileptic drug effects on cognitive networks in patients with refractory epilepsy. In two retrospective studies employing fMRI cognitive tasks, we isolated task- and medication-specific effects on working memory and language networks for Levetiracetam (study 1) and Topiramate and Zonisamide (study 2). In the third project, we employed Voxel-Based-Morphometry in a retrospective analysis of structural imaging of patients who had died of sudden unexpected death in epilepsy (SUDEP) or were at high or low risk of SUDEP. We identified structural markers of high SUDEP risk, and discussed that these were at least partially specific, i.e. independent of disease progression and load

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches