1,239 research outputs found
The equivalence of information-theoretic and likelihood-based methods for neural dimensionality reduction
Stimulus dimensionality-reduction methods in neuroscience seek to identify a
low-dimensional space of stimulus features that affect a neuron's probability
of spiking. One popular method, known as maximally informative dimensions
(MID), uses an information-theoretic quantity known as "single-spike
information" to identify this space. Here we examine MID from a model-based
perspective. We show that MID is a maximum-likelihood estimator for the
parameters of a linear-nonlinear-Poisson (LNP) model, and that the empirical
single-spike information corresponds to the normalized log-likelihood under a
Poisson model. This equivalence implies that MID does not necessarily find
maximally informative stimulus dimensions when spiking is not well described as
Poisson. We provide several examples to illustrate this shortcoming, and derive
a lower bound on the information lost when spiking is Bernoulli in discrete
time bins. To overcome this limitation, we introduce model-based dimensionality
reduction methods for neurons with non-Poisson firing statistics, and show that
they can be framed equivalently in likelihood-based or information-theoretic
terms. Finally, we show how to overcome practical limitations on the number of
stimulus dimensions that MID can estimate by constraining the form of the
non-parametric nonlinearity in an LNP model. We illustrate these methods with
simulations and data from primate visual cortex
Perception of categories: from coding efficiency to reaction times
Reaction-times in perceptual tasks are the subject of many experimental and
theoretical studies. With the neural decision making process as main focus,
most of these works concern discrete (typically binary) choice tasks, implying
the identification of the stimulus as an exemplar of a category. Here we
address issues specific to the perception of categories (e.g. vowels, familiar
faces, ...), making a clear distinction between identifying a category (an
element of a discrete set) and estimating a continuous parameter (such as a
direction). We exhibit a link between optimal Bayesian decoding and coding
efficiency, the latter being measured by the mutual information between the
discrete category set and the neural activity. We characterize the properties
of the best estimator of the likelihood of the category, when this estimator
takes its inputs from a large population of stimulus-specific coding cells.
Adopting the diffusion-to-bound approach to model the decisional process, this
allows to relate analytically the bias and variance of the diffusion process
underlying decision making to macroscopic quantities that are behaviorally
measurable. A major consequence is the existence of a quantitative link between
reaction times and discrimination accuracy. The resulting analytical expression
of mean reaction times during an identification task accounts for empirical
facts, both qualitatively (e.g. more time is needed to identify a category from
a stimulus at the boundary compared to a stimulus lying within a category), and
quantitatively (working on published experimental data on phoneme
identification tasks)
Information transmission in oscillatory neural activity
Periodic neural activity not locked to the stimulus or to motor responses is
usually ignored. Here, we present new tools for modeling and quantifying the
information transmission based on periodic neural activity that occurs with
quasi-random phase relative to the stimulus. We propose a model to reproduce
characteristic features of oscillatory spike trains, such as histograms of
inter-spike intervals and phase locking of spikes to an oscillatory influence.
The proposed model is based on an inhomogeneous Gamma process governed by a
density function that is a product of the usual stimulus-dependent rate and a
quasi-periodic function. Further, we present an analysis method generalizing
the direct method (Rieke et al, 1999; Brenner et al, 2000) to assess the
information content in such data. We demonstrate these tools on recordings from
relay cells in the lateral geniculate nucleus of the cat.Comment: 18 pages, 8 figures, to appear in Biological Cybernetic
Layered Steered SpaceāTime-Spreading-Aided Generalized MC DS-CDMA
AbstractāWe present a novel trifunctional multiple-inputā multiple-output (MIMO) scheme that intrinsically amalgamates spaceātime spreading (STS) to achieve a diversity gain and a Vertical Bell Labs layered spaceātime (V-BLAST) scheme to attain a multiplexing gain in the context of generalized multicarrier direct-sequence code-division multiple access (MC DS-CDMA), as well as beamforming. Furthermore, the proposed system employs both time- and frequency-domain spreading to increase the number of users, which is also combined with a user-grouping technique to reduce the effects of multiuser interference
Evidence of an Off-resonant Electronic Transport Mechanism in Helicenes
Helical molecules have been identified as potential candidates for
investigating electronic transport, spin filtering, or even piezoelectricity.
However, the description of the transport mechanism is not straightforward in
single molecular junctions. In this work, we study the electronic transport in
break junctions of a series of three helical molecules: dithia[]helicenes,
with molecular units, and detail the synthesis of two kinds of
dithia[11]helicenes, varying the location of the sulfur atoms. Our experimental
study demonstrates low conductance values that remain similar across different
biases and molecules. Additionally, we assess the length dependence of the
conductance for each helicene, revealing an exponential decay characteristic of
off-resonant transport. This behaviour is primarily attributed to the
misalignment between the energy levels of the molecule-electrodes system. The
length dependence trend described above is supported by \textit{ab initio}
calculations, further confirming the off-resonant transport mechanism
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