Next generation automotive embedded systems-on-chip and their applications

It is a well known fact in the automotive industry that critical and costly delays in the development cycle of powertrain1 controllers are unavoidable due to the complex nature of the systems-on-chip used in them. The primary goal of this portfolio is to show the development of new methodologies for the fast and efficient implementation of next generation powertrain applications and the associated automotive qualified systems-on-chip. A general guideline for rapid automotive applications development, promoting the integration of state-of-the-art tools and techniques necessary, is presented. The methods developed in this portfolio demonstrate a new and better approach to co-design of automotive systems that also raises the level of design abstraction.An integrated business plan for the development of a camless engine controller platform is presented. The plan provides details for the marketing plan, management and financial data.A comprehensive real-time system level development methodology for the implementation of an electromagnetic actuator based camless internal combustion engine is developed. The proposed development platform enables developers to complete complex software and hardware development before moving to silicon, significantly shortening the development cycle and improving confidence in the design.A novel high performance internal combustion engine knock processing strategy using the next generation automotive system-on-chip, particularly highlighting the capabilities of the first-of-its-kind single-instruction-multiple-data micro-architecture is presented. A patent application has been filed for the methodology and the details of the invention are also presented.Enhancements required for the performance optimisation of several resource properties such as memory accesses, energy consumption and execution time of embedded powertrain applications running on the developed system-on-chip and its next generation of devices is proposed. The approach used allows the replacement of various software segments by hardware units to speed up processing.1 Powertrain: A name applied to the group of components used to transmit engine power to the driving wheels. It can consist of engine, clutch, transmission, universal joints, drive shaft, differential gear, and axle shafts

Fault-tolerant satellite computing with modern semiconductors

Miniaturized satellites enable a variety space missions which were in the past infeasible, impractical or uneconomical with traditionally-designed heavier spacecraft. Especially CubeSats can be launched and manufactured rapidly at low cost from commercial components, even in academic environments. However, due to their low reliability and brief lifetime, they are usually not considered suitable for life- and safety-critical services, complex multi-phased solar-system-exploration missions, and missions with a longer duration. Commercial electronics are key to satellite miniaturization, but also responsible for their low reliability: Until 2019, there existed no reliable or fault-tolerant computer architectures suitable for very small satellites. To overcome this deficit, a novel on-board-computer architecture is described in this thesis.Robustness is assured without resorting to radiation hardening, but through software measures implemented within a robust-by-design multiprocessor-system-on-chip. This fault-tolerant architecture is component-wise simple and can dynamically adapt to changing performance requirements throughout a mission. It can support graceful aging by exploiting FPGA-reconfiguration and mixed-criticality.  Experimentally, we achieve 1.94W power consumption at 300Mhz with a Xilinx Kintex Ultrascale+ proof-of-concept, which is well within the powerbudget range of current 2U CubeSats. To our knowledge, this is the first COTS-based, reproducible on-board-computer architecture that can offer strong fault coverage even for small CubeSats.European Space AgencyComputer Systems, Imagery and Medi

Immunoediting and angiogenesis in ovarian cancer

Advances in the treatment of ovarian cancer have had a limited impact on prognosis over recent decades. Alternatives to the traditional surgical and chemotherapeutic approach are being sought. Many novel therapies relate to a greater understanding of the molecular changes which occur during carcinogenesis and the development of targeted therapies to exploit these abnormalities. The aim of this thesis was to investigate the prognostic significance of markers relating to tumour immunology, angiogenesis and apoptosis, through the use of Tissue Microarray Technology. 339 cases of ovarian cancers diagnosed between 1982 and 1997 were assessed. Tumours were analysed immunohistochemically for expression of components of the IFNy (IFNGR1, STAT1, p27, caspase 1), TRAIL (DR4 and DR5) and angiogenic (VEGF) pathways. Loss of expression of IFNGR1 was an independent predictor of poor prognosis, although STAT 1 was not. High levels of cytoplasmic and nuclear p27 expression were associated with a reduced survival; cytoplasmic was independently prognostic. Tumours with reduced levels of caspase 1 had improved survival. These results suggest that only patients expressing IFNGR1 may benefit from IFNy therapy and provides evidence of immunoediting in ovarian cancer. DR4 and DR5 did not predict prognosis suggesting that the TRAIL pathway may not be significant in ovarian cancer apoptosis with implications for TRAIL-related therapy. High levels of VEGF occurred infrequently, being an independent marker of poor prognosis. This may identify a group of patients who may preferentially benefit from anti-angiogenic therapy. The thesis illustrates that ovarian cancers are heterogeneous and variations in expression of protein markers can predict tumour behaviour and stratify for therapy. Future targeted therapies may be selected on the basis of an immunohistochemical profile which predicts the pathways that are still functioning. New therapies as they arise should be trialed and targeted to tumours expressing the appropriate molecular markers

Immunoediting and angiogenesis in ovarian cancer

Advances in the treatment of ovarian cancer have had a limited impact on prognosis over recent decades. Alternatives to the traditional surgical and chemotherapeutic approach are being sought. Many novel therapies relate to a greater understanding of the molecular changes which occur during carcinogenesis and the development of targeted therapies to exploit these abnormalities. The aim of this thesis was to investigate the prognostic significance of markers relating to tumour immunology, angiogenesis and apoptosis, through the use of Tissue Microarray Technology. 339 cases of ovarian cancers diagnosed between 1982 and 1997 were assessed. Tumours were analysed immunohistochemically for expression of components of the IFNy (IFNGR1, STAT1, p27, caspase 1), TRAIL (DR4 and DR5) and angiogenic (VEGF) pathways. Loss of expression of IFNGR1 was an independent predictor of poor prognosis, although STAT 1 was not. High levels of cytoplasmic and nuclear p27 expression were associated with a reduced survival; cytoplasmic was independently prognostic. Tumours with reduced levels of caspase 1 had improved survival. These results suggest that only patients expressing IFNGR1 may benefit from IFNy therapy and provides evidence of immunoediting in ovarian cancer. DR4 and DR5 did not predict prognosis suggesting that the TRAIL pathway may not be significant in ovarian cancer apoptosis with implications for TRAIL-related therapy. High levels of VEGF occurred infrequently, being an independent marker of poor prognosis. This may identify a group of patients who may preferentially benefit from anti-angiogenic therapy. The thesis illustrates that ovarian cancers are heterogeneous and variations in expression of protein markers can predict tumour behaviour and stratify for therapy. Future targeted therapies may be selected on the basis of an immunohistochemical profile which predicts the pathways that are still functioning. New therapies as they arise should be trialed and targeted to tumours expressing the appropriate molecular markers

A system wide study on the hypertrophic response to salbutamol in skeletal muscle cells

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Empirical models of emissions and energy efficiencies of coal-fired fluidized bed power plants

Mass and energy balances of fluidized bed energy technologies are to a significant degree dependent upon the specific design being investigated. It is difficult to make any generally accurate comments. about these balances. This study attempts to solve this difficulty by displaying a large amount of available data, especially on parametric experiments, for the specific designs. To the extent that generalizations about the efficiencies and emissions of these cycles are.possible empirical correlation models have been developed, along with measures of the predictive quality of these models over existing data bases. These empirical correlations consist of probabilistic models that have been fit to published experimental data. In several instances, there have been comparison of these empirical models with available analytic models. In the cases of unavailable experimental data, such as for the potassium topping cycles, models have been fit to analytic data. Although the overall scale of this effort was very small compared to other fluidized bed reviews, such as those performed at Babcock and Wilcox, Burns and Roe, and Battelle-Columbus, the empirical models are new and in the narrow scope of this study some of-the literature reviews are more comprehensive than others available at this time. Extensive bibliographic research and identification-of on-going projects is also included in this report.Work performed on a subcontract to Exxon Research and Engineering Co., as part of a program sponsored by the U.S. Environmental Protection Agency

Federal Register

Daily publication of the U.S. Office of the Federal Register contains rules and regulations, proposed legislation and rule changes, and other notices, including "Presidential proclamations and Executive Orders, Federal agency documents having general applicability and legal effect, documents required to be published by act of Congress, and other Federal agency documents of public interest" (p. ii). Table of Contents starts on page iii

Federal Register

Daily publication of the U.S. Office of the Federal Register contains rules and regulations, proposed legislation and rule changes, and other notices, including "Presidential proclamations and Executive Orders, Federal agency documents having general applicability and legal effect, documents required to be published by act of Congress, and other Federal agency documents of public interest" (p. ii). Table of Contents starts on page iii

Air Traffic Management Abbreviation Compendium

As in all fields of work, an unmanageable number of abbreviations are used today in aviation for terms, definitions, commands, standards and technical descriptions. This applies in general to the areas of aeronautical communication, navigation and surveillance, cockpit and air traffic control working positions, passenger and cargo transport, and all other areas of flight planning, organization and guidance. In addition, many abbreviations are used more than once or have different meanings in different languages. In order to obtain an overview of the most common abbreviations used in air traffic management, organizations like EUROCONTROL, FAA, DWD and DLR have published lists of abbreviations in the past, which have also been enclosed in this document. In addition, abbreviations from some larger international projects related to aviation have been included to provide users with a directory as complete as possible. This means that the second edition of the Air Traffic Management Abbreviation Compendium includes now around 16,500 abbreviations and acronyms from the field of aviation