An interval-based temporal logic in a multivalued setting

We describe the embedding of the semantic notions and modal operators of a first-order temporal logic based on time intervals in a multivalued setting. Truth values will be realized as functions from time intervals to "ordinary" truth values like t and f. The main emphasis lies on the realization of the various modal operators contained in the temporal logic as operations on the functional truth values. We show that it is possible to obtain an efficient system sufficient for tasks in the area of diagnostic reasoning

Monotone Logic Programming

We propose a notion of an abstract logic. Based on this notion, we define abstract logic programs to be sets of sentences of an abstract logic. When these abstract logics possess certain logical properties (some properties considered are compactness, finitariness, and monotone consequence relations) we show how to develop a fixed-point, model-state-theoretic and proof theoretic semantics for such programs. The work of Melvin Fitting on developing a generalized semantics for multivalued logic programming is extended here to arbitrary abstract logics. We present examples to show how our semantics is robust enough to be applicable to various non-classical logics like temporal logic and multivalued logics, as well as to extensions of classical logic programming such as disjunctive logic programming. We also show how some aspects of the declarative semantics of distributed logic programming, particularly work of Ramanujam, can be incorporated into our framework

TEMPOS: A Platform for Developing Temporal Applications on Top of Object DBMS

This paper presents TEMPOS: a set of models and languages supporting the manipulation of temporal data on top of object DBMS. The proposed models exploit object-oriented technology to meet some important, yet traditionally neglected design criteria related to legacy code migration and representation independence. Two complementary ways for accessing temporal data are offered: a query language and a visual browser. The query language, namely TempOQL, is an extension of OQL supporting the manipulation of histories regardless of their representations, through fully composable functional operators. The visual browser offers operators that facilitate several time-related interactive navigation tasks, such as studying a snapshot of a collection of objects at a given instant, or detecting and examining changes within temporal attributes and relationships. TEMPOS models and languages have been formalized both at the syntactical and the semantical level and have been implemented on top of an object DBMS. The suitability of the proposals with regard to applications' requirements has been validated through concrete case studies

A Dempster-Shafer theory inspired logic.

Issues of formalising and interpreting epistemic uncertainty have always played a prominent role in Artificial Intelligence. The Dempster-Shafer (DS) theory of partial beliefs is one of the most-well known formalisms to address the partial knowledge. Similarly to the DS theory, which is a generalisation of the classical probability theory, fuzzy logic provides an alternative reasoning apparatus as compared to Boolean logic. Both theories are featured prominently within the Artificial Intelligence domain, but the unified framework accounting for all the aspects of imprecise knowledge is yet to be developed. Fuzzy logic apparatus is often used for reasoning based on vague information, and the beliefs are often processed with the aid of Boolean logic. The situation clearly calls for the development of a logic formalism targeted specifically for the needs of the theory of beliefs. Several frameworks exist based on interpreting epistemic uncertainty through an appropriately defined modal operator. There is an epistemic problem with this kind of frameworks: while addressing uncertain information, they also allow for non-constructive proofs, and in this sense the number of true statements within these frameworks is too large. In this work, it is argued that an inferential apparatus for the theory of beliefs should follow premises of Brouwer's intuitionism. A logic refuting tertium non daturìs constructed by defining a correspondence between the support functions representing beliefs in the DS theory and semantic models based on intuitionistic Kripke models with weighted nodes. Without addional constraints on the semantic models and without modal operators, the constructed logic is equivalent to the minimal intuitionistic logic. A number of possible constraints is considered resulting in additional axioms and making the proposed logic intermediate. Further analysis of the properties of the created framework shows that the approach preserves the Dempster-Shafer belief assignments and thus expresses modality through the belief assignments of the formulae within the developed logic

Model Checking to Assess T-Helper Cell Plasticity

Computational modeling constitutes a crucial step toward the functional understanding of complex cellular networks. In particular, logical modeling has proven suitable for the dynamical analysis of large signaling and transcriptional regulatory networks. In this context, signaling input components are generally meant to convey external stimuli, or environmental cues. In response to such external signals, cells acquire specific gene expression patterns modeled in terms of attractors (e.g., stable states). The capacity for cells to alter or reprogram their differentiated states upon changes in environmental conditions is referred to as cell plasticity. In this article, we present a multivalued logical framework along with computational methods recently developed to efficiently analyze large models. We mainly focus on a symbolic model checking approach to investigate switches between attractors subsequent to changes of input conditions. As a case study, we consider the cellular network regulating the differentiation of T-helper (Th) cells, which orchestrate many physiological and pathological immune responses. To account for novel cellular subtypes, we present an extended version of a published model of Th cell differentiation. We then use symbolic model checking to analyze reachability properties between Th subtypes upon changes of environmental cues. This allows for the construction of a synthetic view of Th cell plasticity in terms of a graph connecting subtypes with arcs labeled by input conditions. Finally, we explore novel strategies enabling specific Th cell polarizing or reprograming events.LabEx MemoLife, Ecole Normale Supérieure, FCT grants: (PEst-OE/EEI/LA0021/2013, IF/01333/2013), Ph.D.program of the Agence National de Recherche sur Le Sida (ANRS), European Research Council consolidator grant