Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines

possible anticancer mechanism of action against breast cancer cell lines: non-hormone-dependent MDA-MB-231 and hormonedependent MCF-7. -e leaves of E. longifolia were processed into unfermented and fermented batches before drying using freeze and microwave-oven drying techniques. Obtained extracts were tested for cytotoxicity effect using MTT assay and phenolic determination using HPLC-DAD technique. -e most toxic sample was analyzed for its apoptotic cell quantification, cell cycle distribution, and the expression of caspases and apoptotic protein using flow cytometry technique. Fragmentation of DNA was tested using an agarose gel electrophoresis system. -e results determined that the unfermented freeze-dried leaf extract was the most toxic towards MDA-MB-231 and MCF-7 cells, in a dose-dependent manner. -is extract contains the highest phenolics of gallic acid, chlorogenic acid, ECG, and EGCG. -e DNA fragmentation was observed in both cell lines, where cell cycle was arrested at the G2/M phase in MCF-7 cells and S phase in MDA-MB-231 cells. -e number of apoptotic cells for MDA-MB-231 was increased when the treatment was prolonged from 24 h to 48 h but slightly decreased at 72 h, whereas apoptosis in MCF-7 cells occurred in a time-dependent manner. -ere were significant activities of cytochrome c, caspase-3, Bax, and Bcl-2 apoptotic protein in MDA-MB-231 cells, whereas MCF-7 cells showed significant activities for caspase-8, cytochrome c, Bax, p53, and Bcl-2 apoptotic protein. -ese results indicate the ability of unfermented freeze-dried leaf extract of E. longifolia to induce apoptosis cell death on MDA-MB-231 and MCF-7, as well as real evidence on sample preparation effect towards its cytotoxicity level

The Design of a 360°-Switched-Beam-Base Station Antenna

The concept of switched-beam antenna (SBA) systems covering an area of 360° for wireless base station applications is presented. First, a reconfigurable pattern antenna (RPA), which is composed of an omnidirectional slot-antenna array surrounded by an active cylindrical frequency selective surface (FSS), is studied. The behavior of FSS is controlled by PIN diodes which are able to divide the Azimuth plane into six sectors from one common source. Unfortunately for a sector antenna, a huge number of diodes are required which complicates the structure in terms of efficiency and complexity. However, a simple and an efficient SBA configuration based on a hexagonal Fabry-Pérot cavity leaky wave antenna (FPC LWA) arrays is proposed as a solution for RPA problems. A sector-directive beam is generated from a simple patch antenna embedded inside a resonant Fabry-Pérot cavity with specific dimensions which have an influence on beamwidth and radiation efficiency. To increase more sectorization level and channel’s capacity, the proposed sector in FPC LWA arrays can be divided into three subsectors by using an active high-impedance surface (HIS). As a conclusion, SBA based on FPC LWA is the most suitable solution for future wireless communications

Reflectarray Antenna with Radar Cross-Section Reduction

This paper presents the design of a low RCS reflectarray at 8.52 GHz by replacing the solid metal sheet behind the antenna with a band stop frequency selective surface. A 50 element linear array of omni-directional elements was used to simulate the far field pattern of a reflectarray with f/D=0.325 in the plane of the elements to assess the effect of an imperfect aperture distribution on the gain and sidelobe levels. It is found that the reflection loss variation across the aperture does not have a significant effect on the radiation pattern of the antenna, because for the layout that was studied, only a few of resonant loops were predicted to give a significantly different loss than the others in the array. Simulated and measured results show that the ‘in-band’ reflection phase response of the structure with metal ground plane and with a periodic FSS ground plane is very similar, however the periodic ground plane reduces the ‘out of band’ reflectivity by more than 4 dB, thereby decreasing its RCS profile to these signals

Tunable antenna design by metamaterial structures operating at S band

Un “metamaterial” por su definición ampliamente aceptada es una estructura construida artificialmente que obtiene sus propiedades materiales de su estructura en lugar de la composición de su material intrínseco. El ámbito de los materiales ha ganado mucha atención dentro de la comunidad científica en la última década. Con los continuos avances y descubrimientos conducen al camino de las aplicaciones prácticas; los metamateriales han ganado la atención de las empresas de base tecnológica y los organismos de defensa interesados en el uso de dispositivos de próxima generación. Las superficies selectivas en frecuencia (FSS) son una variedad potente de metamateriales que, dependiendo de la geometría de la superficie, se pueden utilizar para diseñar propiedades de radiación específicas tales como la emisión direccional, emisión polarizada circular y lineal, y la selectividad espectral. Los elementos de la FSS pueden ser tanto elementos metálicos sólidos como elementos metálicos con aberturas, y en los diseños tradicionales, la superficie selectiva en frecuencia (FSS) normalmente opera en torno a la resonancia de media longitud de onda de los elementos. En este proyecto se va a utilizar una superficie selectiva de frecuencia (FSS) con el fin de realizar metamateriales sintonizables -una amplia clase de metamateriales controlables diseñados artificialmente, y desarrollar una antena sintonizable que trabaje a 2.4 GHz. La FSS consiste en una serie de elementos rectángulos cargados con varactores y capacitores con una película delgada de material ferroeléctrico sintonizable (BST) para el ajuste externo de los parámetros de medio efectivo. Por lo tanto se diseñan unos varactores BST que son colocados entre los elementos metálicos que conforman la FSS. El efecto de la superficie selectiva en frecuencia es estudiado en dos antenas diferentes – antena ELPOSD (End-Loaded Planar Open-Sleeve Dipole) y una antena de parche microstrip. La antena ELPOSD consiste en un dipolo plano convencional con dos elementos parásitos muy juntos, y una carga en cada extremo del dipolo. Los beneficios principales de este tipo de antenas es que, además del rendimiento similar de la antena POSD (Planar Open-Sleeve Dipole) convencional, las antenas ELPOSD pueden ser miniaturizadas. La antena parche utilizada en este trabajo es un elemento metálico cuadrado plano alimentado a través de una línea microstrip. El material ferroeléctrico Barium Strontium Titanate (BST) es un material muy bien conocido hasta el momento. Para diseñar los varactores se utiliza una película delgada de BST, junto con los capacitores interdigitales (IDCs) que se utilizan en la capa del metal. La antena general consiste en un sustrato de múltiples capas donde en una capa se encuentra la Superficie selectiva en frecuencia (FSS) sintonizable y en otra la antena dipolo o antena de parche. La capacidad de la FSS completa varía introduciendo el material ferroeléctrico BST en el varactor. Como puede verse en los resultados, variando la permitividad del material BST de 200 a 300 se consigue una variación en frecuencia de 4.15 GHz a 3.5 GHz con una distancia alrededor de 100 MHz entre frecuencias resonantes. Esto equivale a una variación de la frecuencia alrededor del 8% entre los valores de permitividad adyacentes.A “metamaterial” by its widely accepted definition is an artificially engineered structure that gains its material properties from its structure as opposed to its intrinsic material composition. The field of metamaterials has gained much attention within the scientific community over the past decade. With continuing advances and discoveries leading the way to practical applications, metamaterials have earned the attention of technology-based corporations and defense agencies interested in their use for next generation devices. Frequency Selective Surfaces (FSS) are a potent variety of metamaterials that, depending on the surface geometry, can be used to engineer specific radiation properties such as directional emission, linear and circular polarized emission, and spectral selectivity. The elements of the FSS can either be patches or apertures, and in traditional designs, the FSS usually operates around the half-wavelength resonance of the elements. In this project a Frequency Selective Surface (FSS) is used in order to realize tunable metamaterials –a broad class of controllable artificially engineered metamaterials, and develop a tunable antenna operating at 2.4 GHz. The FSS consist of an array of square patches loaded with varactors and tunable ferroelectric thin film capacitors (BST) for external tuning of the effective medium parameters. Therefore a BST varactor is designed and located between the patches of the FSS. The effect of the Frequency Selective Surface is studied in two different antennas –an End-Loaded Planar Open-Sleeve Dipole (ELPOSD) and a Square Patch. An End-Loaded Planar Open-Sleeve Dipole consist of a conventional planar dipole with two closely spaced parasitic elements, or sleeves, and loaded stubs at the end of the dipole. The main benefits of this type of antennas is that in addition to retaining similar performance to that of conventional planar open-sleeve dipole, end-loaded planar opensleeve dipole (ELPOSD) antennas can be miniaturized. The Square Patch antenna used in this work is a conventional planar square patch feed with a microstrip line. Barium Strontium Titanate (BST) is a well-known ferroelectric material and up to now. A BST thin film is used to design the varactors, along with the Interdigital Capacitors (IDCs) geometry used in the metal layer. The overall antenna consists of a multilayer substrate with tunable FSS layer and dipole or patch antenna. The capacitance of the whole FSS changes introducing the BST ferroelectric material into the varactor. As can be seen in the results, by varying the BST permittivity from 200 to 300, a variation in frequency is achieved from 1.98 GHz to 1.717 GHz with a distance around 100 MHz between resonance frequencies, which equals a variation of the frequency about 8% in the adjacent permittivity values.Ingeniería de TelecomunicaciónTelekomunikazio Ingeniaritz

2009 Index IEEE Antennas and Wireless Propagation Letters Vol. 8

This index covers all technical items - papers, correspondence, reviews, etc. - that appeared in this periodical during the year, and items from previous years that were commented upon or corrected in this year. Departments and other items may also be covered if they have been judged to have archival value. The Author Index contains the primary entry for each item, listed under the first author\u27s name. The primary entry includes the coauthors\u27 names, the title of the paper or other item, and its location, specified by the publication abbreviation, year, month, and inclusive pagination. The Subject Index contains entries describing the item under all appropriate subject headings, plus the first author\u27s name, the publication abbreviation, month, and year, and inclusive pages. Note that the item title is found only under the primary entry in the Author Index

2008 Index IEEE Transactions on Control Systems Technology Vol. 16

This index covers all technical items - papers, correspondence, reviews, etc. - that appeared in this periodical during the year, and items from previous years that were commented upon or corrected in this year. Departments and other items may also be covered if they have been judged to have archival value. The Author Index contains the primary entry for each item, listed under the first author\u27s name. The primary entry includes the coauthors\u27 names, the title of the paper or other item, and its location, specified by the publication abbreviation, year, month, and inclusive pagination. The Subject Index contains entries describing the item under all appropriate subject headings, plus the first author\u27s name, the publication abbreviation, month, and year, and inclusive pages. Note that the item title is found only under the primary entry in the Author Index

A metasurfaces review: Definitions and applications

This paper is a critical review of metasurfaces, which are planar metamaterials. Metamaterials offer bespoke electromagnetic applications and novel properties which are not found in naturally occurring materials. However, owing to their 3D-nature and resonant characteristics, they suffer from manufacturing complexity, losses and are highly dispersive. The 2-dimensional nature of metasurfaces allows ease of fabrication and integration into devices. The phase discontinuity across the metasurface offers anomalous refraction, thereby conserving the good metamaterial properties while still offering the low-loss characteristics. The paper discusses salient features and applications of metasurfaces; wavefront shaping; phase jumps; non-linear metasurfaces; and their use as frequency selective surfaces (FSS)

Analysis and Review of Fabry Perot Resonator Antennas (FPRA)

A Fabry-Perot Resonator (FPR) antenna has found wide applications in microwave and millimetre waves and recently attracted considerable interest. In this paper, research progress on FPR antenna, a literature review on FPR antenna has been discussed. Further paper describes introduction, basics of Fabry perot cavity and PRS(Partially Reflective surface)& its applications, structure of FP cavity (FPC) model &finally improvement of gain bandwidthusing various methods are illustrated