EDMON - Electronic Disease Surveillance and Monitoring Network: A Personalized Health Model-based Digital Infectious Disease Detection Mechanism using Self-Recorded Data from People with Type 1 Diabetes

Through time, we as a society have been tested with infectious disease outbreaks of different magnitude, which often pose major public health challenges. To mitigate the challenges, research endeavors have been focused on early detection mechanisms through identifying potential data sources, mode of data collection and transmission, case and outbreak detection methods. Driven by the ubiquitous nature of smartphones and wearables, the current endeavor is targeted towards individualizing the surveillance effort through a personalized health model, where the case detection is realized by exploiting self-collected physiological data from wearables and smartphones. This dissertation aims to demonstrate the concept of a personalized health model as a case detector for outbreak detection by utilizing self-recorded data from people with type 1 diabetes. The results have shown that infection onset triggers substantial deviations, i.e. prolonged hyperglycemia regardless of higher insulin injections and fewer carbohydrate consumptions. Per the findings, key parameters such as blood glucose level, insulin, carbohydrate, and insulin-to-carbohydrate ratio are found to carry high discriminative power. A personalized health model devised based on a one-class classifier and unsupervised method using selected parameters achieved promising detection performance. Experimental results show the superior performance of the one-class classifier and, models such as one-class support vector machine, k-nearest neighbor and, k-means achieved better performance. Further, the result also revealed the effect of input parameters, data granularity, and sample sizes on model performances. The presented results have practical significance for understanding the effect of infection episodes amongst people with type 1 diabetes, and the potential of a personalized health model in outbreak detection settings. The added benefit of the personalized health model concept introduced in this dissertation lies in its usefulness beyond the surveillance purpose, i.e. to devise decision support tools and learning platforms for the patient to manage infection-induced crises

K-CUSUM: Cluster Detection Mechanism in EDMON

Source at https://www.ep.liu.se/ecp/contents.asp?issue=161. The main goal of the EDMON (Electronic Disease Monitoring Network) project is to detect the spread of contagious diseases at the earliest possible moment, and potentially before people know that they have been infected. The results shall be visualized on real-time maps as well as presented in digital communication. In this paper, a hybrid of K-nearness Neighbor (KNN) and cumulative sum (CUSUM), known as K-CUSUM, were explored and implemented with a prototype approach. The KNN algorithm, which was implemented in the K- CUSUM, recorded 99.52% accuracy when it was tested with simulated dataset containing geolocation coordinates among other features and SckitLearn KNN algorithm achieved an accuracy of 93.81% when it was tested with the same dataset. After injection of spikes of known outbreaks in the simulated data, the CUSUM module was totally specific and sensitive by correctly identifying all outbreaks and non-outbreak clusters. Suitable methods for obtaining a balance point of anonymizing geolocation attributes towards obscuring the privacy and confidentiality of diabetes subjects’ trajectories while maintaining the data requirements for public good, in terms of disease surveillance, remains a challenge

A systematic review of cluster detection mechanisms in syndromic surveillance: Towards developing a framework of cluster detection mechanisms for EDMON system

Source at http://www.ep.liu.se/ecp/151/011/ecp18151011.pdf.Time lag in detecting disease outbreaks remains a threat to global health security. Currently, our research team is working towards a system called EDMON, which uses blood glucose level and other supporting parameters from people with type 1 diabetes, as indicator variables for outbreak detection. Therefore, this paper aims to pinpoint the state of the art cluster detection mechanism towards developing an efficient framework to be used in EDMON and other similar syndromic surveillance systems. Various challenges such as user mobility, privacy and confidentiality, geographical location estimation and other factors have been considered. To this end, we conducted a systematic review exploring different online scholarly databases. Considering peer reviewed journals and articles, literatures search was conducted between January and March 2018. Relevant literatures were identified using the title, keywords, and abstracts as a preliminary filter with the inclusion criteria and a full text review were done for literatures that were found to be relevant. A total of 28 articles were included in the study. The result indicates that various clustering and aberration detection algorithms have been developed and tested up to the task. In this regard, privacy preserving policies and high computational power requirement were found challenging since it restrict usage of specific locations for syndromic surveillance

Graph Matching Based Decision Support Tools For Mitigating Spread Of Infectious Diseases Like H1N1

Diseases like H1N1 can be prevented from becoming a wide spread epidemic through timely detection and containment measures. Similarity of H1N1 symptoms to any common flu and its alarming rate of spread through animals and humans complicate the deployment of such strategies. We use dynamic implementation of graph matching methods to overcome these challenges. Specifically, we formulate a mixed integer programming model (MIP) that analyzes patient symptom data available at hospitals to generate patient graph match scores. Successful matches are then used to update counters that generate alerts to the Public Health Department when the counters surpass the threshold values. Since multiple factors like age, health status, etc., influence vulnerability of exposed population and severity of those already infected, a heuristic that dynamically updates patient graph match scores based on the values of these factors is developed. To better understand the gravity of the situation at hand and achieve timely containment, the rate of infection and size of infected population in a specific region needs to be estimated. To this effect, we propose an algorithm that clusters the hospitals in a region based on the population they serve. Hospitals grouped together affect counters that are local to the population they serve. Analysis of graph match scores and counter values specific to the cluster helps identify the region that needs containment attention and determine the size and severity of infection in that region. We demonstrate the application of our models via a case study on emergency department patients arriving at hospitals in Buffalo, NY

Current Perspectives on Viral Disease Outbreaks

The COVID-19 pandemic has reminded the world that infectious diseases are still important. The last 40 years have experienced the emergence of new or resurging viral diseases such as AIDS, ebola, MERS, SARS, Zika, and others. These diseases display diverse epidemiologies ranging from sexual transmission to vector-borne transmission (or both, in the case of Zika). This book provides an overview of recent developments in the detection, monitoring, treatment, and control of several viral diseases that have caused recent epidemics or pandemics

Biotechnology to Combat COVID-19

This book provides an inclusive and comprehensive discussion of the transmission, science, biology, genome sequencing, diagnostics, and therapeutics of COVID-19. It also discusses public and government health measures and the roles of media as well as the impact of society on the ongoing efforts to combat the global pandemic. It addresses almost every topic that has been studied so far in the research on SARS-CoV-2 to gain insights into the fundamentals of the disease and mitigation strategies. This volume is a useful resource for virologists, epidemiologists, biologists, medical professionals, public health and government professionals, and all global citizens who have endured and battled against the pandemic

Surveillance and Response to Infectious Diseases and Comorbidities: An African and German Perspective

Cite: Academy of Science of South Africa (ASSAf), (2019). Surveillance and Response to Infectious Diseases and Comorbidities: An African and German Perspective [Available online] DOI http://dx.doi.org/10.17159/assaf.2019/0042The conference explored various topics pertaining to Infectious Diseases and Comorbidities. These included: antimicrobial resistance; one health; HIV; TB; Malaria; and HCV. The objectives of the symposium were to scientifically analyse challenges pertaining to infectious diseases and comorbidities as they relate to surveillance, responses and diagnostics; identify current and future research needs that can be employed to tacle emrging scientific challenges; Assess possible solutions to current challenges as they relate to surveillance and response to infectious diseases and morbidities and how these can be used to provide science advice to governments; and, exchange scientific information between young and senior scientists from the sub-Saharan Africa and Germany.Academy of Science of South Africa (ASSAf

COVID19: Current Challenges and Future Perspectives

This Special Issue focuses on recent global research on the current coronavirus (COVID-19) pandemic. The disease is caused by a novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The International Committee on Taxonomy of Viruses (ICTV) named the virus SARS-CoV-2, as it is genetically related to the coronavirus responsible for the SARS outbreak of 2003. While related, the two viruses are quite different in their behaviour. At the time of submission for publication (7 January 2022), COVID-19, named by the World Health Organization (WHO) on 11 February 2020, had caused more than 296.5 million cases and over 5.5 million deaths with over 2.6 million new cases in the past 24 h. The COVID-19 pandemic has greatly affected the capacity of health systems providing essential health care, but more than 9.195 billion vaccine doses have been administered as of 10 January 2021. There have been 22 papers published upon peer review acceptance in this Special Issue, including one editorial, twelve research papers, three review papers and seven other papers, including one perspective, two case reports, one brief report, two viewpoints and one commentary. They each contribute to a much better understanding of COVID-19