The admission experience survey italian version (I-AES). a factor analytic study on a sample of 156 acute psychiatric in-patients

Coercive treatments are often regarded as an inevitable and yet highly debated feature of psychiatric care. Perceived coercion is often reported by patients involuntarily committed as well as their voluntary counterparts. The Admission Experience Survey (AES) is a reliable tool for measuring perceived coercion in mental hospital admission. We developed the Italian AES (I-AES) through translation back-translation and administered it to 156 acutely hospitalized patients (48% women, 69% voluntarily committed) in two university hospitals in Rome (Policlinico Umberto I, Sant'Andrea Hospital). A principal component analysis (PCA) with equamax rotation was conducted. The I-AES showed good internal consistency (Cronbach's alpha = 0.90); Guttmann split-half relia- bility coefficient was 0.90. AES total score significantly differed between voluntary and involuntary committed patients (5.08 ± 4.1 vs. 8.1 ± 4.9, p < .05). PCA disclosed a three-factor solution explaining 59.3 of the variance. Some discrepancies were found between the factor structure of the I-AES and the original version. I- AES total score was positively associated with numbers of previous involuntarily hospitalization (r = 0.20, p < .05) and psychiatric symptoms' severity (r = 0.22, p < .02). I-AES and its proposed new factor structure proved to be reliable to assess perceived coercion in mental hospital admission. Consequently, it may represent a helpful instrument for the study and reduction of patients' levels of perceived coercion

The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network

Background: Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients. Treatment algorithms for the management of common ipilimumab-induced AEs have lead to a reduction of morbidity, e.g. due to bowel perforations. However, the spectrum of less common AEs is expanding as ipilimumab is increasingly applied. Stringent recognition and management of AEs will reduce drug-induced morbidity and costs, and thus, positively impact the cost-benefit ratio of the drug. To facilitate timely identification and adequate management data on rare AEs were analyzed at 19 skin cancer centers. Methods and Findings: Patient files (n = 752) were screened for rare ipilimumab-associated AEs. A total of 120 AEs, some of which were life-threatening or even fatal, were reported and summarized by organ system describing the most instructive cases in detail. Previously unreported AEs like drug rash with eosinophilia and systemic symptoms (DRESS), granulomatous inflammation of the central nervous system, and aseptic meningitis, were documented. Obstacles included patientś delay in reporting symptoms and the differentiation of steroid-induced from ipilimumab-induced AEs under steroid treatment. Importantly, response rate was high in this patient population with tumor regression in 30.9% and a tumor control rate of 61.8% in stage IV melanoma patients despite the fact that some patients received only two of four recommended ipilimumab infusions. This suggests that ipilimumab-induced antitumor responses can have an early onset and that severe autoimmune reactions may reflect overtreatment. Conclusion: The wide spectrum of ipilimumab-induced AEs demands doctor and patient awareness to reduce morbidity and treatment costs and true ipilimumab success is dictated by both objective tumor responses and controlling severe side effects

Poly-substance use and sexual risk behaviours: a cross-sectional comparison of adolescents in mainstream and alternative education settings

Background: Surveys of young people under-represent those in alternative education settings (AES), potentially disguising health inequalities. We present the first quantitative UK evidence of health inequalities between AES and mainstream education school (MES) pupils, assessing whether observed inequalities are attributable to socioeconomic, familial, educational and peer factors. Methods: Cross-sectional, self-reported data on individual- and poly-substance use (PSU: combined tobacco, alcohol and cannabis use) and sexual risk-taking from 219 pupils in AES (mean age 15.9 years) were compared with data from 4024 pupils in MES (mean age 15.5 years). Data were collected from 2008 to 2009 as part of the quasi-experimental evaluation of Healthy Respect 2 (HR2). Results: AES pupils reported higher levels of substance use, including tobacco use, weekly drunkenness, using cannabis at least once a week and engaging in PSU at least once a week. AES pupils also reported higher levels of sexual health risk behaviours than their MES counterparts, including: earlier sexual activity; less protection against sexually transmitted infections (STIs); and having 3+ lifetime sexual partners. In multivariate analyses, inequalities in sexual risk-taking were fully explained after adjusting for higher deprivation, lower parental monitoring, lower parent-child connectedness, school disengagement and heightened intentions towards early parenthood among AES vs MES pupils. However, an increased risk (OR = 1.73, 95% CI 1.15, 2.60) of weekly PSU was found for AES vs MES pupils after adjusting for these factors and the influence of peer behaviours. Conclusion: AES pupils are more likely to engage in health risk behaviours, including PSU and sexual risk-taking, compared with MES pupils. AES pupils are a vulnerable group who may not be easily targeted by conventional population-level public health programmes. Health promotion interventions need to be tailored and contextualised for AES pupils, in particular for sexual health and PSU. These could be included within interventions designed to promote broader outcomes such as mental wellbeing, educational engagement, raise future aspirations and promote resilience

Empirical evaluation of an adaptive e-learning system and the effects of knowledge, learning styles and multimedia mode on student achievement

This paper presents an empirical evaluation of an adaptive e-learning system (AES). The system was evaluated in an experimental research. During the 9 weeks of experimentation, the students studied the learning material in two randomly allocated groups, an experimental group using the AES and a control group using the non-AES. Research findings are described as follows. Students who learned using the AES performed better significantly than those who learned using the non-AES. The implementation of test repetition as a function of knowledge adaptation in the AES increased student achievement significantly. When the effect of test repetition was removed, the implementation of learning style and multimedia mode adaptation in the AES was still found to have significant effect upon student performance. Students whose learning style and multimedia preferences were matched with the system achieved better results

Chromoelectric fields and quarkonium-hadron interactions at high energies

We develop a simple model to study the heavy quarkonium-hadron cross section in the high energy limit. The hadron is represented by an external electric color field (capacitor) and the heavy quarkonium is represented by a small color dipole. Using high energy approximations we compute the relevant cross sections, which are then compared with results obtained with other methods. Our calculations are presented in a pedagogical way accessible to undergraduate students.Comment: To appear in Physical Review C, 24 pages, 10 eps figure

The price of tumor control

Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients. Treatment algorithms for the management of common ipilimumab-induced AEs have lead to a reduction of morbidity, e.g. due to bowel perforations. However, the spectrum of less common AEs is expanding as ipilimumab is increasingly applied. Stringent recognition and management of AEs will reduce drug-induced morbidity and costs, and thus, positively impact the cost-benefit ratio of the drug. To facilitate timely identification and adequate management data on rare AEs were analyzed at 19 skin cancer centers. Patient files (n = 752) were screened for rare ipilimumab-associated AEs. A total of 120 AEs, some of which were life-threatening or even fatal, were reported and summarized by organ system describing the most instructive cases in detail. Previously unreported AEs like drug rash with eosinophilia and systemic symptoms (DRESS), granulomatous inflammation of the central nervous system, and aseptic meningitis, were documented. Obstacles included patientś delay in reporting symptoms and the differentiation of steroid-induced from ipilimumab-induced AEs under steroid treatment. Importantly, response rate was high in this patient population with tumor regression in 30.9% and a tumor control rate of 61.8% in stage IV melanoma patients despite the fact that some patients received only two of four recommended ipilimumab infusions. This suggests that ipilimumab-induced antitumor responses can have an early onset and that severe autoimmune reactions may reflect overtreatment. The wide spectrum of ipilimumab-induced AEs demands doctor and patient awareness to reduce morbidity and treatment costs and true ipilimumab success is dictated by both objective tumor responses and controlling severe side effects

AES-CBC Software Execution Optimization

With the proliferation of high-speed wireless networking, the necessity for efficient, robust and secure encryption modes is ever increasing. But, cryptography is primarily a computationally intensive process. This paper investigates the performance and efficiency of IEEE 802.11i approved Advanced Encryption Standard (AES)-Rijndael ciphering/deciphering software in Cipher Block Chaining (CBC) mode. Simulations are used to analyse the speed, resource consumption and robustness of AES-CBC to investigate its viability for image encryption usage on common low power devices. The detailed results presented in this paper provide a basis for performance estimation of AES cryptosystems implemented on wireless devices. The use of optimized AES-CBC software implementation gives a superior encryption speed performance by 12 - 30%, but at the cost of twice more memory for code size.Comment: 8 pages, IEEE 200

Analysing Relations involving small number of Monomials in AES S- Box

In the present day, AES is one the most widely used and most secure Encryption Systems prevailing. So, naturally lots of research work is going on to mount a significant attack on AES. Many different forms of Linear and differential cryptanalysis have been performed on AES. Of late, an active area of research has been Algebraic Cryptanalysis of AES, where although fast progress is being made, there are still numerous scopes for research and improvement. One of the major reasons behind this being that algebraic cryptanalysis mainly depends on I/O relations of the AES S- Box (a major component of the AES). As, already known, that the key recovery algorithm of AES can be broken down as an MQ problem which is itself considered hard. Solving these equations depends on our ability reduce them into linear forms which are easily solvable under our current computational prowess. The lower the degree of these equations, the easier it is for us to linearlize hence the attack complexity reduces. The aim of this paper is to analyze the various relations involving small number of monomials of the AES S- Box and to answer the question whether it is actually possible to have such monomial equations for the S- Box if we restrict the degree of the monomials. In other words this paper aims to study such equations and see if they can be applicable for AES.Comment: 5 pages, 1 tabl