Social media mental health analysis framework through applied computational approaches

Studies have shown that mental illness burdens not only public health and productivity but also established market economies throughout the world. However, mental disorders are difficult to diagnose and monitor through traditional methods, which heavily rely on interviews, questionnaires and surveys, resulting in high under-diagnosis and under-treatment rates. The increasing use of online social media, such as Facebook and Twitter, is now a common part of people’s everyday life. The continuous and real-time user-generated content often reflects feelings, opinions, social status and behaviours of individuals, creating an unprecedented wealth of person-specific information. With advances in data science, social media has already been increasingly employed in population health monitoring and more recently mental health applications to understand mental disorders as well as to develop online screening and intervention tools. However, existing research efforts are still in their infancy, primarily aimed at highlighting the potential of employing social media in mental health research. The majority of work is developed on ad hoc datasets and lacks a systematic research pipeline. [Continues.]</div

Leveraging a machine learning based predictive framework to study brain-phenotype relationships

An immense collective effort has been put towards the development of methods forquantifying brain activity and structure. In parallel, a similar effort has focused on collecting experimental data, resulting in ever-growing data banks of complex human in vivo neuroimaging data. Machine learning, a broad set of powerful and effective tools for identifying multivariate relationships in high-dimensional problem spaces, has proven to be a promising approach toward better understanding the relationships between the brain and different phenotypes of interest. However, applied machine learning within a predictive framework for the study of neuroimaging data introduces several domain-specific problems and considerations, leaving the overarching question of how to best structure and run experiments ambiguous. In this work, I cover two explicit pieces of this larger question, the relationship between data representation and predictive performance and a case study on issues related to data collected from disparate sites and cohorts. I then present the Brain Predictability toolbox, a soft- ware package to explicitly codify and make more broadly accessible to researchers the recommended steps in performing a predictive experiment, everything from framing a question to reporting results. This unique perspective ultimately offers recommen- dations, explicit analytical strategies, and example applications for using machine learning to study the brain

Supervised machine learning in psychiatry:towards application in clinical practice

In recent years, the field of machine learning (often named with the more general term artificial intelligence) has literally exploded and its application has been proposed in basically all fields, including psychiatry and mental health. This has been motivated by the promise of using machine learning to develop new clinical tools that could help perform personalized predictions and recommendations, ultimately improving the results achievable in the psychiatric clinical practice that still faces only a limited success in the fight against mental diseases. However, despite this huge interest, there is still a substantial lack of tools in psychiatry that are based on machine learning algorithms. Massimiliano Grassi, in his Ph.D. thesis, investigates the challenges of translating machine learning algorithms into clinical practice and proposes innovative solutions to these challenges. The thesis presents the development and validation of new algorithms for the prediction of the onset of Alzheimer’s disease, the remission of obsessive-compulsive disorder, and the automatization of sleep staging in polysomnography, a method to diagnose sleep disorders. The results from these studies demonstrate that the use of machine learning in psychiatric clinical practice is not just a promise, and it is possible to develop machine learning algorithms that achieve clinically relevant performance even if based solely on information that can be easily accessible in the daily clinical routine

Exploring a Generalizable Machine Learned Solution for Early Prediction of Student At-Risk Status

Determining which students are at-risk of poorer outcomes -- such as dropping out, failing classes, or decreasing standardized examination scores -- has become an important area of both research and practice in K-12 education. The models produced from this type of predictive modeling research are increasingly used by high schools in Early Warning Systems to identify which students are at risk and intervene to support better outcomes. It has become common practice to re-build and validate these detectors, district-by-district, due to different data semantics and various risk factors for students in different districts. As these detectors become more widely used, however, a new challenge emerges in applying these detectors across a broad spectrum of school districts with varying availability of past student data. Some districts have insufficient high-quality past data for building an effective detector. Novel approaches that can address the complex data challenges a new district presents are critical for advancing the field. Using an ensemble-based algorithm, I develop a modeling approach that can generate a useful model for a previously unseen district. During the ensembling process, my approach, District Similarity Ensemble Extrapolation (DSEE), weights districts that are more similar to the Target district more strongly during ensembling than less similar districts. Using this approach, I can predict student-at-risk status effectively for unseen districts, across a range of grade ranges, and achieve prediction goodness but ultimately fails to perform better than the previously published Knowles (2015) and Bowers (2012) EWS models proposed for use across districts

Big Data Analytics and Information Science for Business and Biomedical Applications

The analysis of Big Data in biomedical as well as business and financial research has drawn much attention from researchers worldwide. This book provides a platform for the deep discussion of state-of-the-art statistical methods developed for the analysis of Big Data in these areas. Both applied and theoretical contributions are showcased