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Advancing Artificial Intelligence in Sensors, Signals, and Imaging Informatics.
ObjectiveTo identify research works that exemplify recent developments in the field of sensors, signals, and imaging informatics.MethodA broad literature search was conducted using PubMed and Web of Science, supplemented with individual papers that were nominated by section editors. A predefined query made from a combination of Medical Subject Heading (MeSH) terms and keywords were used to search both sources. Section editors then filtered the entire set of retrieved papers with each paper having been reviewed by two section editors. Papers were assessed on a three-point Likert scale by two section editors, rated from 0 (do not include) to 2 (should be included). Only papers with a combined score of 2 or above were considered.ResultsA search for papers was executed at the start of January 2019, resulting in a combined set of 1,459 records published in 2018 in 119 unique journals. Section editors jointly filtered the list of candidates down to 14 nominations. The 14 candidate best papers were then ranked by a group of eight external reviewers. Four papers, representing different international groups and journals, were selected as the best papers by consensus of the International Medical Informatics Association (IMIA) Yearbook editorial board.ConclusionsThe fields of sensors, signals, and imaging informatics have rapidly evolved with the application of novel artificial intelligence/machine learning techniques. Studies have been able to discover hidden patterns and integrate different types of data towards improving diagnostic accuracy and patient outcomes. However, the quality of papers varied widely without clear reporting standards for these types of models. Nevertheless, a number of papers have demonstrated useful techniques to improve the generalizability, interpretability, and reproducibility of increasingly sophisticated models
New Models for Wolf-Rayet and O Star Populations in Young Starbursts
Using the latest stellar evolution models, theoretical stellar spectra, and a
compilation of observed emission line strengths from Wolf-Rayet (WR) stars, we
construct evolutionary synthesis models for young starbursts. We explicitly
distinguish between the various WR subtypes (WN, WC, WO), and we treat O and Of
stars separately. We provide detailed predictions of UV and optical emission
line strengths for both the WR stellar lines and the major nebular hydrogen and
helium emission lines, as a function of several input parameters related to the
starburst episode. We also derive the theoretical frequency of WR-rich
starbursts. We then discuss: nebular HeII 4686 emission, the contribution of WR
stars to broad Balmer line emission, techniques used to derive the WR and O
star content from integrated spectra, and explore the implications of the
formation of WR stars through mass transfer in close binary systems in
instantaneous bursts. The observational features predicted by our models allow
a detailed quantitative determination of the massive star population in a
starburst region (particularly in so-called "WR galaxies") from its integrated
spectrum and provide a means of deriving the burst properties (e.g., duration,
age) and the parameters of the initial mass function of young starbursts.
(Abridged abstract)Comment: Accepted by ApJ Supplements. LaTeX using aasmp4, psfigs macros. 49
pages including 23 figures. Paper (full, or text/figures separated) and
detailed model results available at
http://www.stsci.edu/ftp/science/starburst/sv97.htm
Wearable sensors system for an improved analysis of freezing of gait in Parkinson's disease using electromyography and inertial signals
We propose a wearable sensor system for automatic, continuous and ubiquitous analysis of Freezing of Gait (FOG), in patients affected by Parkinson's disease. FOG is an unpredictable gait disorder with different clinical manifestations, as the trembling and the shuffling-like phenotypes, whose underlying pathophysiology is not fully understood yet. Typical trembling-like subtype features are lack of postural adaptation and abrupt trunk inclination, which in general can increase the fall probability. The targets of this work are detecting the FOG episodes, distinguishing the phenotype and analyzing the muscle activity during and outside FOG, toward a deeper insight in the disorder pathophysiology and the assessment of the fall risk associated to the FOG subtype. To this aim, gyroscopes and surface electromyography integrated in wearable devices sense simultaneously movements and action potentials of antagonist leg muscles. Dedicated algorithms allow the timely detection of the FOG episode and, for the first time, the automatic distinction of the FOG phenotypes, which can enable associating a fall risk to the subtype. Thanks to the possibility of detecting muscles contractions and stretching exactly during FOG, a deeper insight into the pathophysiological underpinnings of the different phenotypes can be achieved, which is an innovative approach with respect to the state of art
Survey on solar X-ray flares and associated coherent radio emissions
The radio emission during 201 X-ray selected solar flares was surveyed from
100 MHz to 4 GHz with the Phoenix-2 spectrometer of ETH Zurich. The selection
includes all RHESSI flares larger than C5.0 jointly observed from launch until
June 30, 2003. Detailed association rates of radio emission during X-ray flares
are reported. In the decimeter wavelength range, type III bursts and the
genuinely decimetric emissions (pulsations, continua, and narrowband spikes)
were found equally frequently. Both occur predominantly in the peak phase of
hard X-ray (HXR) emission, but are less in tune with HXRs than the
high-frequency continuum exceeding 4 GHz, attributed to gyrosynchrotron
radiation. In 10% of the HXR flares, an intense radiation of the above genuine
decimetric types followed in the decay phase or later. Classic meter-wave type
III bursts are associated in 33% of all HXR flares, but only in 4% they are the
exclusive radio emission. Noise storms were the only radio emission in 5% of
the HXR flares, some of them with extended duration. Despite the spatial
association (same active region), the noise storm variations are found to be
only loosely correlated in time with the X-ray flux. In a surprising 17% of the
HXR flares, no coherent radio emission was found in the extremely broad band
surveyed. The association but loose correlation between HXR and coherent radio
emission is interpreted by multiple reconnection sites connected by common
field lines.Comment: Solar Physics, in pres
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images
of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL
maps are derived through computational staining using a convolutional neural network trained to
classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and
correlation with overall survival. TIL map structural patterns were grouped using standard
histopathological parameters. These patterns are enriched in particular T cell subpopulations
derived from molecular measures. TIL densities and spatial structure were differentially enriched
among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial
infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic
patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for
the TCGA image archives with insights into the tumor-immune microenvironment
VICARED: A Neural Network Based System for the Detection of Electrical Disturbances in Real Time
The study of the quality of electric power lines is usually known as
Power Quality. Power quality problems are increasingly due to a proliferation
of equipment that is sensitive and polluting at the same time. The detection and
classification of the different disturbances which cause power quality problems
is a difficult task which requires a high level of engineering knowledge. Thus,
neural networks are usually a good choice for the detection and classification of
these disturbances. This paper describes a powerful system for detection of
electrical disturbances by means of neural networks
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