Volume and shape in feature space on adaptive FCM in MRI segmentation.

Intensity non-uniformity (bias field) correction, contextual constraints over spatial intensity distribution and non-spherical cluster\u27s shape in the feature space are incorporated into the fuzzy c-means (FCM) for segmentation of three-dimensional multi-spectral MR images. The bias field is modeled by a linear combination of smooth polynomial basis functions for fast computation in the clustering iterations. Regularization terms for the neighborhood continuity of either intensity or membership are added into the FCM cost functions. Since the feature space is not isotropic, distance measures, other than the Euclidean distance, are used to account for the shape and volumetric effects of clusters in the feature space. The performance of segmentation is improved by combining the adaptive FCM scheme with the criteria used in Gustafson-Kessel (G-K) and Gath-Geva (G-G) algorithms through the inclusion of the cluster scatter measure. The performance of this integrated approach is quantitatively evaluated on normal MR brain images using the similarity measures. The improvement in the quality of segmentation obtained with our method is also demonstrated by comparing our results with those produced by FSL (FMRIB Software Library), a software package that is commonly used for tissue classification

STOCHASTIC SEASONAL MODELS FOR GLUCOSE PREDICTION IN TYPE 1 DIABETES

[ES] La diabetes es un importante problema de salud mundial, siendo una de las enfermedades no transmisibles más graves después de las enfermedades cardiovasculares, el cáncer y las enfermedades respiratorias crónicas. La prevalencia de la diabetes ha aumentado constantemente en las últimas décadas, especialmente en países de ingresos bajos y medios. Se estima que 425 millones de personas en todo el mundo tenían diabetes en 2017, y para 2045 este número puede aumentar a 629 millones. Alrededor del 10% de las personas con diabetes padecen diabetes tipo 1, caracterizada por una destrucción autoinmune de las células beta en el páncreas, responsables de la secreción de la hormona insulina. Sin insulina, la glucosa plasmática aumenta a niveles nocivos, provocando complicaciones vasculares a largo plazo. Hasta que se encuentre una cura, el manejo de la diabetes depende de los avances tecnológicos para terapias de reemplazo de insulina. Con la llegada de los monitores continuos de glucosa, la tecnología ha evolucionado hacia sistemas automatizados. Acuñados como "páncreas artificial", los dispositivos de control de glucosa en lazo cerrado suponen hoy en día un cambio de juego en el manejo de la diabetes. La investigación en las últimas décadas ha sido intensa, dando lugar al primer sistema comercial a fines de 2017, y muchos más están siendo desarrollados por las principales industrias de dispositivos médicos. Sin embargo, como dispositivo de primera generación, muchos problemas aún permanecen abiertos y nuevos avances tecnológicos conducirán a mejoras del sistema para obtener mejores resultados de control glucémico y reducir la carga del paciente, mejorando significativamente la calidad de vida de las personas con diabetes tipo 1. En el centro de cualquier sistema de páncreas artificial se encuentra la predicción de glucosa, tema abordado en esta tesis. La capacidad de predecir la glucosa a lo largo de un horizonte de predicción dado, y la estimación de las tendencias futuras de glucosa, es la característica más importante de cualquier sistema de páncreas artificial, para poder tomar medidas preventivas que eviten por completo el riesgo para el paciente. La predicción de glucosa puede aparecer como parte del algoritmo de control en sí, como en sistemas basados en técnicas de control predictivo basado en modelo (MPC), o como parte de un sistema de supervisión para evitar episodios de hipoglucemia. Sin embargo, predecir la glucosa es un problema muy desafiante debido a la gran variabilidad inter e intra-sujeto que sufren los pacientes, cuyas fuentes solo se entienden parcialmente. Esto limita las prestaciones predictivas de los modelos, imponiendo horizontes de predicción relativamente cortos, independientemente de la técnica de modelado utilizada (modelos fisiológicos, basados en datos o híbridos). La hipótesis de partida de esta tesis es que la complejidad de la dinámica de la glucosa requiere la capacidad de caracterizar grupos de comportamientos en los datos históricos del paciente que llevan naturalmente al concepto de modelado local. Además, la similitud de las respuestas en un grupo puede aprovecharse aún más para introducir el concepto clásico de estacionalidad en la predicción de glucosa. Como resultado, los modelos locales estacionales están en el centro de esta tesis. Se utilizan varias bases de datos clínicas que incluyen comidas mixtas y ejercicio para demostrar la viabilidad y superioridad de las prestaciones de este enfoque.[CA] La diabetisés un important problema de salut mundial, sent una de les malalties no transmissibles més greus després de les malalties cardiovasculars, el càncer i les malalties respiratòries cròniques. La prevalença de la diabetis ha augmentat constantment en les últimes dècades, especialment en països d'ingressos baixos i mitjans. S'estima que 425 milions de persones a tot el món tenien diabetis en 2017, i per 2045 aquest nombre pot augmentar a 629 milions. Al voltant del 10% de les persones amb diabetis pateixen diabetis tipus 1, caracteritzada per una destrucció autoimmune de les cèl·lules beta en el pàncrees, responsables de la secreció de l'hormona insulina. Sense insulina, la glucosa plasmàtica augmenta a nivells nocius, provocant complicacions vasculars a llarg termini. Fins que es trobi una cura, el maneig de la diabetis depén dels avenços tecnològics per a teràpies de reemplaçament d'insulina. Amb l'arribada dels monitors continus de glucosa, la tecnologia ha evolucionat cap a sistemes automatitzats. Encunyats com "pàncrees artificial", els dispositius de control de glucosa en llaç tancat suposen avui dia un canvi de joc en el maneig de la diabetis. La investigació en les últimes dècades ha estat intensa, donant lloc al primer sistema comercial a finals de 2017, i molts més estan sent desenvolupats per les principals indústries de dispositius mèdics. No obstant això, com a dispositiu de primera generació, molts problemes encara romanen oberts i nous avenços tecnològics conduiran a millores del sistema per obtenir millors resultats de control glucèmic i reduir la càrrega del pacient, millorant significativament la qualitat de vida de les persones amb diabetis tipus 1. Al centre de qualsevol sistema de pàncrees artificial es troba la predicció de glucosa, tema abordat en aquesta tesi. La capacitat de predir la glucosa al llarg d'un horitzó de predicció donat, i l'estimació de les tendències futures de glucosa, és la característica més important de qualsevol sistema de pàncrees artificial, per poder prendre mesures preventives que evitin completament el risc per el pacient. La predicció de glucosa pot aparèixer com a part de l'algoritme de control en si, com en sistemes basats en técniques de control predictiu basat en model (MPC), o com a part d'un sistema de supervisió per evitar episodis d'hipoglucèmia. No obstant això, predir la glucosa és un problema molt desafiant degut a la gran variabilitat inter i intra-subjecte que pateixen els pacients, les fonts només s'entenen parcialment. Això limita les prestacions predictives dels models, imposant horitzons de predicció relativament curts, independentment de la tècnica de modelatge utilitzada (models fisiològics, basats en dades o híbrids). La hipòtesi de partida d'aquesta tesi és que la complexitat de la dinàmica de la glucosa requereix la capacitat de caracteritzar grups de comportaments en les dades històriques del pacient que porten naturalment al concepte de modelatge local. A més, la similitud de les respostes en un grup pot aprofitar-se encara més per introduir el concepte clàssic d'estacionalitat en la predicció de glucosa. Com a resultat, els models locals estacionals estan al centre d'aquesta tesi. S'utilitzen diverses bases de dades clíniques que inclouen menjars mixtes i exercici per demostrar la viabilitat i superioritat de les prestacions d'aquest enfocament.[EN] Diabetes is a significant global health problem, one of the most serious noncommunicable diseases after cardiovascular diseases, cancer and chronic respiratory diseases. Diabetes prevalence has been steadily increasing over the past decades, especially in low- and middle-income countries. It is estimated that 425 million people worldwide had diabetes in 2017, and by 2045 this number may rise to 629 million. About 10% of people with diabetes suffer from type 1 diabetes, characterized by autoimmune destruction of the beta-cells in the pancreas, responsible for the secretion of the hormone insulin. Without insulin, plasma glucose rises to deleterious levels, provoking long-term vascular complications. Until a cure is found, the management of diabetes relies on technological developments for insulin replacement therapies. With the advent of continuous glucose monitors, technology has been evolving towards automated systems. Coined as "artificial pancreas", closed-loop glucose control devices are nowadays a game-changer in diabetes management. Research in the last decades has been intense, yielding a first commercial system in late 2017 and many more are in the pipeline of the main medical devices industry. However, as a first-generation device, many issues still remain open and new technological advancements will lead to system improvements for better glycemic control outputs and reduced patient's burden, improving significantly the quality of life of people with type 1 diabetes. At the core of any artificial pancreas system is glucose prediction, the topic addressed in this thesis. The ability to predict glucose along a given prediction horizon, and estimation of future glucose trends, is the most important feature of any artificial pancreas system, in order to be able to take preventive actions to entirely avoid risk to the patient. Glucose prediction can appear as part of the control algorithm itself, such as in systems based on model predictive control (MPC) techniques, or as part of a monitoring system to avoid hypoglycemic episodes. However, predicting glucose is a very challenging problem due to the large inter- and intra-subject variability that patients suffer, whose sources are only partially understood. These limits models forecasting performance, imposing relatively short prediction horizons, despite the modeling technique used (physiological, data-driven or hybrid approaches). The starting hypothesis of this thesis is that the complexity of glucose dynamics requires the ability to characterize clusters of behaviors in the patient's historical data naturally yielding to the concept of local modeling. Besides, the similarity of responses in a cluster can be further exploited to introduce the classical concept of seasonality into glucose prediction. As a result, seasonal local models are at the core of this thesis. Several clinical databases including mixed meals and exercise are used to demonstrate the feasibility and superiority of the performance of this approach.This work has been supported by the Spanish Ministry of Economy and Competitiveness (MINECO) under the FPI grant BES-2014-069253 and projects DPI2013-46982-C2-1-R and DPI2016-78831-C2-1-R. Moreover, with relation to this grant, a short stay was done at the end of 2017 at the Illinois Institute of Technology, Chicago, United States of America, under the supervision of Prof. Ali Cinar, for four months from 01/09/2017 to 29/12/2017.Montaser Roushdi Ali, E. (2020). STOCHASTIC SEASONAL MODELS FOR GLUCOSE PREDICTION IN TYPE 1 DIABETES [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/136574TESI

Dynamic non-linear system modelling using wavelet-based soft computing techniques

The enormous number of complex systems results in the necessity of high-level and cost-efficient modelling structures for the operators and system designers. Model-based approaches offer a very challenging way to integrate a priori knowledge into the procedure. Soft computing based models in particular, can successfully be applied in cases of highly nonlinear problems. A further reason for dealing with so called soft computational model based techniques is that in real-world cases, many times only partial, uncertain and/or inaccurate data is available. Wavelet-Based soft computing techniques are considered, as one of the latest trends in system identification/modelling. This thesis provides a comprehensive synopsis of the main wavelet-based approaches to model the non-linear dynamical systems in real world problems in conjunction with possible twists and novelties aiming for more accurate and less complex modelling structure. Initially, an on-line structure and parameter design has been considered in an adaptive Neuro- Fuzzy (NF) scheme. The problem of redundant membership functions and consequently fuzzy rules is circumvented by applying an adaptive structure. The growth of a special type of Fungus (Monascus ruber van Tieghem) is examined against several other approaches for further justification of the proposed methodology. By extending the line of research, two Morlet Wavelet Neural Network (WNN) structures have been introduced. Increasing the accuracy and decreasing the computational cost are both the primary targets of proposed novelties. Modifying the synoptic weights by replacing them with Linear Combination Weights (LCW) and also imposing a Hybrid Learning Algorithm (HLA) comprising of Gradient Descent (GD) and Recursive Least Square (RLS), are the tools utilised for the above challenges. These two models differ from the point of view of structure while they share the same HLA scheme. The second approach contains an additional Multiplication layer, plus its hidden layer contains several sub-WNNs for each input dimension. The practical superiority of these extensions is demonstrated by simulation and experimental results on real non-linear dynamic system; Listeria Monocytogenes survival curves in Ultra-High Temperature (UHT) whole milk, and consolidated with comprehensive comparison with other suggested schemes. At the next stage, the extended clustering-based fuzzy version of the proposed WNN schemes, is presented as the ultimate structure in this thesis. The proposed Fuzzy Wavelet Neural network (FWNN) benefitted from Gaussian Mixture Models (GMMs) clustering feature, updated by a modified Expectation-Maximization (EM) algorithm. One of the main aims of this thesis is to illustrate how the GMM-EM scheme could be used not only for detecting useful knowledge from the data by building accurate regression, but also for the identification of complex systems. The structure of FWNN is based on the basis of fuzzy rules including wavelet functions in the consequent parts of rules. In order to improve the function approximation accuracy and general capability of the FWNN system, an efficient hybrid learning approach is used to adjust the parameters of dilation, translation, weights, and membership. Extended Kalman Filter (EKF) is employed for wavelet parameters adjustment together with Weighted Least Square (WLS) which is dedicated for the Linear Combination Weights fine-tuning. The results of a real-world application of Short Time Load Forecasting (STLF) further re-enforced the plausibility of the above technique

Parametric Optimization of Taper Cutting Process using Wire Electrical Discharge Machining (WEDM)

Significant technological advancement of wire electrical discharge machining (WEDM) process has been observed in recent times in order to meet the requirements of various manufacturing fields especially in the production of parts with complex geometry in precision die industry. Taper cutting is an important application of WEDM process aiming at generating complex parts with tapered profiles. Wire deformation and breakage are more pronounced in taper cutting as compared with straight cutting resulting in adverse effect on desired taper angle and surface integrity. The reasons for associated problems may be attributed to certain stiffness of the wire. However, controlling the process parameters can somewhat reduce these problems. Extensive literature review reveals that effect of process parameters on various performance measures in taper cutting using WEDM is also not adequately addressed. Hence, study on effect of process parameters on performance measures using various advanced metals and metal matrix composites (MMC) has become the predominant research area in this field. In this context, the present work attempts to experimentally investigate the machining performance of various alloys, super alloys and metal matrix composite during taper cutting using WEDM process. The effect of process parameters such as part thickness, taper angle, pulse duration, discharge current, wire speed and wire tension on various performance measures such as angular error, surface roughness, cutting rate and white layer thickness are studied using Taguchi’s analysis. The functional relationship between the input parameters and performance measures has been developed by using non-linear regression analysis. Simultaneous optimization of the performance measures has been carried out using latest nature inspired algorithms such as multi-objective particle swarm optimization (MOPSO) and bat algorithm. Although MOPSO develops a set of non-dominated solutions, the best ranked solution is identified from a large number of solutions through application of maximum deviation method rather than resorting to human judgement. Deep cryogenic treatment of both wire and work material has been carried out to enhance the machining efficiency of the low conductive work material like Inconel 718. Finally, artificial intelligent models are proposed to predict the various performance measures prior to machining. The study offers useful insight into controlling the parameters to improve the machining efficiency

Prototype based clustering in high-dimensional feature spaces

...In dieser Arbeit untersuche ich den ”Fluch der Dimensionen” mittels dem Begriff der Distanzkonzentration. Ich zeige, dass dieser Effekt im Datenmodell mittels der paarweisen Kovarianzkoeffizienten der Randverteilungen beschrieben werden kann. Zusätzlich vergleiche ich 10 prototypbasierte Clusteralgorithmen mittels 800.000 Clusterergebnissen von künstlich erzeugten Datensätzen. Ich erforsche, wie und warum Clusteralgorithmen von der Anzahl der Merkmale beeinflusst werden. Mit den Clusterergebnissen untersuche ich außerdem, wie gut 5 der populärsten Clusterqualitätsmaße die tatsächliche Clusterqualität schätzen.Magdeburg, Univ., Fak. für Informatik, Diss., 2015von Roland Winkle

Parametric Optimization of Taper Cutting Process using Wire Electrical Discharge Machining (WEDM)

Significant technological advancement of wire electrical discharge machining (WEDM) process has been observed in recent times in order to meet the requirements of various manufacturing fields especially in the production of parts with complex geometry in precision die industry. Taper cutting is an important application of WEDM process aiming at generating complex parts with tapered profiles. Wire deformation and breakage are more pronounced in taper cutting as compared with straight cutting resulting in adverse effect on desired taper angle and surface integrity. The reasons for associated problems may be attributed to certain stiffness of the wire. However, controlling the process parameters can somewhat reduce these problems. Extensive literature review reveals that effect of process parameters on various performance measures in taper cutting using WEDM is also not adequately addressed. Hence, study on effect of process parameters on performance measures using various advanced metals and metal matrix composites (MMC) has become the predominant research area in this field. In this context, the present work attempts to experimentally investigate the machining performance of various alloys, super alloys and metal matrix composite during taper cutting using WEDM process. The effect of process parameters such as part thickness, taper angle, pulse duration, discharge current, wire speed and wire tension on various performance measures such as angular error, surface roughness, cutting rate and white layer thickness are studied using Taguchi’s analysis. The functional relationship between the input parameters and performance measures has been developed by using non-linear regression analysis. Simultaneous optimization of the performance measures has been carried out using latest nature inspired algorithms such as multi-objective particle swarm optimization (MOPSO) and bat algorithm. Although MOPSO develops a set of non-dominated solutions, the best ranked solution is identified from a large number of solutions through application of maximum deviation method rather than resorting to human judgement. Deep cryogenic treatment of both wire and work material has been carried out to enhance the machining efficiency of the low conductive work material like Inconel 718. Finally, artificial intelligent models are proposed to predict the various performance measures prior to machining. The study offers useful insight into controlling the parameters to improve the machining efficiency

Fuzzy Transfer Learning

The use of machine learning to predict output from data, using a model, is a well studied area. There are, however, a number of real-world applications that require a model to be produced but have little or no data available of the specific environment. These situations are prominent in Intelligent Environments (IEs). The sparsity of the data can be a result of the physical nature of the implementation, such as sensors placed into disaster recovery scenarios, or where the focus of the data acquisition is on very defined user groups, in the case of disabled individuals. Standard machine learning approaches focus on a need for training data to come from the same domain. The restrictions of the physical nature of these environments can severely reduce data acquisition making it extremely costly, or in certain situations, impossible. This impedes the ability of these approaches to model the environments. It is this problem, in the area of IEs, that this thesis is focussed. To address complex and uncertain environments, humans have learnt to use previously acquired information to reason and understand their surroundings. Knowledge from different but related domains can be used to aid the ability to learn. For example, the ability to ride a road bicycle can help when acquiring the more sophisticated skills of mountain biking. This humanistic approach to learning can be used to tackle real-world problems where a-priori labelled training data is either difficult or not possible to gain. The transferral of knowledge from a related, but differing context can allow for the reuse and repurpose of known information. In this thesis, a novel composition of methods are brought together that are broadly based on a humanist approach to learning. Two concepts, Transfer Learning (TL) and Fuzzy Logic (FL) are combined in a framework, Fuzzy Transfer Learning (FuzzyTL), to address the problem of learning tasks that have no prior direct contextual knowledge. Through the use of a FL based learning method, uncertainty that is evident in dynamic environments is represented. By combining labelled data from a contextually related source task, and little or no unlabelled data from a target task, the framework is shown to be able to accomplish predictive tasks using models learned from contextually different data. The framework incorporates an additional novel five stage online adaptation process. By adapting the underlying fuzzy structure through the use of previous labelled knowledge and new unlabelled information, an increase in predictive performance is shown. The framework outlined is applied to two differing real-world IEs to demonstrate its ability to predict in uncertain and dynamic environments. Through a series of experiments, it is shown that the framework is capable of predicting output using differing contextual data