Geometric Path Integrals. A Language for Multiscale Biology and Systems Robustness

In this paper we suggest that, under suitable conditions, supervised learning can provide the basis to formulate at the microscopic level quantitative questions on the phenotype structure of multicellular organisms. The problem of explaining the robustness of the phenotype structure is rephrased as a real geometrical problem on a fixed domain. We further suggest a generalization of path integrals that reduces the problem of deciding whether a given molecular network can generate specific phenotypes to a numerical property of a robustness function with complex output, for which we give heuristic justification. Finally, we use our formalism to interpret a pointedly quantitative developmental biology problem on the allowed number of pairs of legs in centipedes

Multiple phases in stochastic dynamics: geometry and probabilities

Stochastic dynamics is generated by a matrix of transition probabilities. Certain eigenvectors of this matrix provide observables, and when these are plotted in the appropriate multi-dimensional space the phases (in the sense of phase transitions) of the underlying system become manifest as extremal points. This geometrical construction, which we call an \textit{observable-representation of state space}, can allow hierarchical structure to be observed. It also provides a method for the calculation of the probability that an initial points ends in one or another asymptotic state

Image processing as state reconstruction in optics

The image reconstruction of partially coherent light is interpreted as the quantum state reconstruction. The efficient method based on maximum-likelihood estimation is proposed to acquire information from registered intensity measurements affected by noise. The connection with totally incoherent image restoration is pointed out. The feasibility of the method is demonstrated numerically. Spatial and correlation details significantly smaller than the diffraction limit are revealed in the reconstructed pattern.Comment: 10 pages, 5 figure

Extreme-Value Copulas

Being the limits of copulas of componentwise maxima in independent random samples, extreme-value copulas can be considered to provide appropriate models for the dependence structure between rare events. Extreme-value copulas not only arise naturally in the domain of extreme-value theory, they can also be a convenient choice to model general positive dependence structures. The aim of this survey is to present the reader with the state-of-the-art in dependence modeling via extreme-value copulas. Both probabilistic and statistical issues are reviewed, in a nonparametric as well as a parametric context.Comment: 20 pages, 3 figures. Minor revision, typos corrected. To appear in F. Durante, W. Haerdle, P. Jaworski, and T. Rychlik (editors) "Workshop on Copula Theory and its Applications", Lecture Notes in Statistics -- Proceedings, Springer 201