Minimum energy configurations of the 2-dimensional HP-model of proteins by self-organizing networks

We use self-organizing maps (SOM) as an efficient tool to find the minimum energy configurations of the 2-dimensional HP-models of proteins. The usage of the SOM for the protein folding problem is similar to that for the Traveling Salesman Problem. The lattice nodes represent the cities whereas the neurons in the network represent the amino acids moving towards the closest cities, subject to the HH interactions. The valid path that maximizes the HH contacts corresponds to the minimum energy configuration of the protein. We report promising results for the cases when the protein completely fills a lattice and discuss the current problems and possible extensions. In all the test sequences up to 36 amino acids, the algorithm was able to find the global minimum and its degeneracies

Traveling Salesman Problem

This book is a collection of current research in the application of evolutionary algorithms and other optimal algorithms to solving the TSP problem. It brings together researchers with applications in Artificial Immune Systems, Genetic Algorithms, Neural Networks and Differential Evolution Algorithm. Hybrid systems, like Fuzzy Maps, Chaotic Maps and Parallelized TSP are also presented. Most importantly, this book presents both theoretical as well as practical applications of TSP, which will be a vital tool for researchers and graduate entry students in the field of applied Mathematics, Computing Science and Engineering

Traveling Salesman Problem

The idea behind TSP was conceived by Austrian mathematician Karl Menger in mid 1930s who invited the research community to consider a problem from the everyday life from a mathematical point of view. A traveling salesman has to visit exactly once each one of a list of m cities and then return to the home city. He knows the cost of traveling from any city i to any other city j. Thus, which is the tour of least possible cost the salesman can take? In this book the problem of finding algorithmic technique leading to good/optimal solutions for TSP (or for some other strictly related problems) is considered. TSP is a very attractive problem for the research community because it arises as a natural subproblem in many applications concerning the every day life. Indeed, each application, in which an optimal ordering of a number of items has to be chosen in a way that the total cost of a solution is determined by adding up the costs arising from two successively items, can be modelled as a TSP instance. Thus, studying TSP can never be considered as an abstract research with no real importance