16 research outputs found

    Jornadas Nacionales de Investigación en Ciberseguridad: actas de las VIII Jornadas Nacionales de Investigación en ciberseguridad: Vigo, 21 a 23 de junio de 2023

    Get PDF
    Jornadas Nacionales de Investigación en Ciberseguridad (8ª. 2023. Vigo)atlanTTicAMTEGA: Axencia para a modernización tecnolóxica de GaliciaINCIBE: Instituto Nacional de Cibersegurida

    Advances in Forensic Genetics

    Get PDF
    The book has 25 articles about the status and new directions in forensic genetics. Approximately half of the articles are invited reviews, and the remaining articles deal with new forensic genetic methods. The articles cover aspects such as sampling DNA evidence at the scene of a crime; DNA transfer when handling evidence material and how to avoid DNA contamination of items, laboratory, etc.; identification of body fluids and tissues with RNA; forensic microbiome analysis with molecular biology methods as a supplement to the examination of human DNA; forensic DNA phenotyping for predicting visible traits such as eye, hair, and skin colour; new ancestry informative DNA markers for estimating ethnic origin; new genetic genealogy methods for identifying distant relatives that cannot be identified with conventional forensic DNA typing; sensitive DNA methods, including single-cell DNA analysis and other highly specialised and sensitive methods to examine ancient DNA from unidentified victims of war; forensic animal genetics; genetics of visible traits in dogs; statistical tools for interpreting forensic DNA analyses, including the most used IT tools for forensic STR-typing and DNA sequencing; haploid markers (Y-chromosome and mitochondria DNA); inference of ethnic origin; a comprehensive logical framework for the interpretation of forensic genetic DNA data; and an overview of the ethical aspects of modern forensic genetics

    Enhancing Reaction-based de novo Design using Machine Learning

    Get PDF
    De novo design is a branch of chemoinformatics that is concerned with the rational design of molecular structures with desired properties, which specifically aims at achieving suitable pharmacological and safety profiles when applied to drug design. Scoring, construction, and search methods are the main components that are exploited by de novo design programs to explore the chemical space to encourage the cost-effective design of new chemical entities. In particular, construction methods are concerned with providing strategies for compound generation to address issues such as drug-likeness and synthetic accessibility. Reaction-based de novo design consists of combining building blocks according to transformation rules that are extracted from collections of known reactions, intending to restrict the enumerated chemical space into a manageable number of synthetically accessible structures. The reaction vector is an example of a representation that encodes topological changes occurring in reactions, which has been integrated within a structure generation algorithm to increase the chances of generating molecules that are synthesisable. The general aim of this study was to enhance reaction-based de novo design by developing machine learning approaches that exploit publicly available data on reactions. A series of algorithms for reaction standardisation, fingerprinting, and reaction vector database validation were introduced and applied to generate new data on which the entirety of this work relies. First, these collections were applied to the validation of a new ligand-based design tool. The tool was then used in a case study to design compounds which were eventually synthesised using very similar procedures to those suggested by the structure generator. A reaction classification model and a novel hierarchical labelling system were then developed to introduce the possibility of applying transformations by class. The model was augmented with an algorithm for confidence estimation, and was used to classify two datasets from industry and the literature. Results from the classification suggest that the model can be used effectively to gain insights on the nature of reaction collections. Classified reactions were further processed to build a reaction class recommendation model capable of suggesting appropriate reaction classes to apply to molecules according to their fingerprints. The model was validated, then integrated within the reaction vector-based design framework, which was assessed on its performance against the baseline algorithm. Results from the de novo design experiments indicate that the use of the recommendation model leads to a higher synthetic accessibility and a more efficient management of computational resources

    Chair a session/Integration of theory and practice in the learning and teaching process

    Get PDF
    The theme for AAEE-2017 is “Integrated Engineering”, which covers a range of sub-themes, such as: Integration of theory and practice in the learning and teaching process Interdisciplinary and cross-disciplinary engineering programs and learning environments Integration of teaching and research in the engineering training process The role and impact of engineering students and educators in the wider community Systems perspectives on engineering education. Integration is also about connections, e.g. between students and teachers, between students in learning together, and between educational institutions and industry and wider society in the engineering education process

    A new strategy for active learning to maximise performance in intensive courses

    Get PDF
    This paper describes an innovation in the delivery of an introductory thermodynamics course offered to students studying towards an engineering qualification. The course was delivered in intensive format, across three weeks of study. Students find it challenging to engage with complex engineering topics in a short period of time, and there is no sizeable study break for pre-exam study. This means that students cannot afford to delay in learning and applying content. Every class must be an opportunity to interact with the content immediately. The innovation described here involved implementing a new daily structure for the course that attempted to mimic the standard process by which students learn material, apply it, study it and practice it in across a traditional-length semester. The new structure involved integrating the lecture and recitation components to the course to increasing the active learning during material delivery, then allowing students to engage in guided study and open-book formative assessment. This paper describes the implementation of this innovation. A brief review of the literature on intensive courses is provided, followed by a description of the approach used in this particular class. The results are then presented, and evaluated in the context of the research and the instructor’s own critical reflection

    Student Expectations: The effect of student background and experience

    Get PDF
    CONTEXT The perspectives and previous experiences that students bring to their programs of study can affect their approaches to study and the depth of learning that they achieve Prosser & Trigwell, 1999; Ramsden, 2003). Graduate outcomes assume the attainment of welldeveloped independent learning skills which can be transferred to the work-place. PURPOSE This 5-year longitudinal study investigates factors influencing students’ approaches to learning in the fields of Engineering, Software Engineering, and Computer Science, at two higher education institutes delivering programs of various levels in Australia and New Zealand. The study aims to track the development of student approaches to learning as they progress through their program. Through increased understanding of students’ approaches, faculty will be better able to design teaching and learning strategies to meet the needs of an increasingly diverse student body. This paper reports on the first stage of the project. APPROACH In August 2017, we ran a pilot of our survey using the Revised Study Process Questionnaire(Biggs, Kember, & Leung, 2001) and including some additional questions related to student demographics and motivation for undertaking their current program of study. Data were analysed to evaluate the usefulness of data collected and to understand the demographics of the student cohort. Over the period of the research, data will be collected using the questionnaire and through focus groups and interviews. RESULTS Participants provided a representative sample, and the data collected was reasonable, allowing the questionnaire design to be confirmed. CONCLUSIONS At this preliminary stage, the study has provided insight into the student demographics at both institutes and identified aspects of students’ modes of engagement with learning. Some areas for improvement of the questionnaire have been identified, which will be implemented for the main body of the study

    Ramon Llull's Ars Magna

    Get PDF
    corecore