The asexual genome of Drosophila

The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments. Selection under linkage can induce clonal interference, a specific mode of evolution by competition of genetic clades within a population. This mode is well known in asexually evolving microbes, but has not been traced systematically in an obligate sexual organism. Here we show that the Drosophila genome is partitioned into two modes of evolution: a local interference regime with limited effects of genetic linkage, and an interference condensate with clonal competition. We map these modes by differences in mutation frequency spectra, and we show that the transition between them occurs at a threshold recombination rate that is predictable from genomic summary statistics. We find the interference condensate in segments of low-recombining sequence that are located primarily in chromosomal regions flanking the centromeres and cover about 20% of the Drosophila genome. Condensate regions have characteristics of asexual evolution that impact gene function: the efficacy of selection and the speed of evolution are lower and the genetic load is higher than in regions of local interference. Our results suggest that multicellular eukaryotes can harbor heterogeneous modes and tempi of evolution within one genome. We argue that this variation generates selection on genome architecture

Adaptive Multicell 3D Beamforming in Multi-Antenna Cellular Networks

We consider a cellular network with multi-antenna base stations (BSs) and single-antenna users, multicell cooperation, imperfect channel state information, and directional antennas each with a vertically adjustable beam. We investigate the impact of the elevation angle of the BS antenna pattern, denoted as tilt, on the performance of the considered network when employing either a conventional single-cell transmission or a fully cooperative multicell transmission. Using the results of this investigation, we propose a novel hybrid multicell cooperation technique in which the intercell interference is controlled via either cooperative beamforming in the horizontal plane or coordinated beamfroming in the vertical plane of the wireless channel, denoted as adaptive multicell 3D beamforming. The main idea is to divide the coverage area into two disjoint vertical regions and adapt the multicell cooperation strategy at the BSs when serving each region. A fair scheduler is used to share the time-slots between the vertical regions. It is shown that the proposed technique can achieve performance comparable to that of a fully cooperative transmission but with a significantly lower complexity and signaling requirements. To make the performance analysis computationally efficient, analytical expressions for the user ergodic rates under different beamforming strategies are also derived.Comment: Accepted for publication in IEEE Transaction on Vehicular Technolog

A review of RFI mitigation techniques in microwave radiometry

Radio frequency interference (RFI) is a well-known problem in microwave radiometry (MWR). Any undesired signal overlapping the MWR protected frequency bands introduces a bias in the measurements, which can corrupt the retrieved geophysical parameters. This paper presents a literature review of RFI detection and mitigation techniques for microwave radiometry from space. The reviewed techniques are divided between real aperture and aperture synthesis. A discussion and assessment of the application of RFI mitigation techniques is presented for each type of radiometer.Peer ReviewedPostprint (published version

Controlling chaos in the quantum regime using adaptive measurements

The continuous monitoring of a quantum system strongly influences the emergence of chaotic dynamics near the transition from the quantum regime to the classical regime. Here we present a feedback control scheme that uses adaptive measurement techniques to control the degree of chaos in the driven-damped quantum Duffing oscillator. This control relies purely on the measurement backaction on the system, making it a uniquely quantum control, and is only possible due to the sensitivity of chaos to measurement. We quantify the effectiveness of our control by numerically computing the quantum Lyapunov exponent over a wide range of parameters. We demonstrate that adaptive measurement techniques can control the onset of chaos in the system, pushing the quantum-classical boundary further into the quantum regime

Bilinear time-frequency representations of heart rate variability and respiration during stress

Recently, joint time-frequency signal representation has received considerable attention as a powerful tool for analyzing a variety of signals and systems. In particular, if the frequency content is time varying as in signals of biological origin which often do not comply with the stationarity assumptions, then this approach is quite attractive. In this dissertation, we explore the possibility of better representation of two particular biological signals, namely heart rate variability (HRV) and respiration. We propose the use of time-frequency analysis as a new and innovative approach to examine the physical and mental exertion attributed to exercise. Two studies are used for the main investigation, the preliminary and anticipation protocols. In the first phase of this work, the application of five different bilinear representations on modeled HRV test signals and experimental HRV and respiration signals of the preliminary protocol is evaluated. Each distribution: the short time Fourier transform (STFT), the pseudo Wigner-Ville (WVD), the smoothed pseudo Wigner-Ville (SPWVD), The Choi-Williams (CWD), and the Born-Jordan-Cohen (RID) has unique characteristics which is shown to affect the amount of smoothing and the generation of cross-terms differently . The CWD and the SPWVD are chosen for further application because of overcoming the drawbacks of the other distributions by providing higher resolution in time arid frequency while suppressing interferences between the signal components. In the second phase of this research, the SPWVD and CWD are used to investigate the presence of an anticipatory component due to the stressful exercise condition as reflected in the HRV signal from a change in behavior in the autonomic nervous system. By expanding the concept of spectral analysis of heart rate variability (HRV) into time-frequency analysis, we are able to quantitatively assess the parasympathetic (HF) and sympatho-vagal balance (LF:HF) changes as a function of time. As a result, the assessment of the autonomic nervous system during rapid changes is made. A new methodology is also proposed that adaptively uncovers the region of parasympathetic activity. It is well known that parasympathetic activity is highly correlated with the respiration frequency. This technique traces the respiration frequency and extracts the corresponding parasympathetic activity from the heart rate variability signal by adaptive filtering