General Iteration graphs and Boolean automata circuits

This article is set in the field of regulation networks modeled by discrete dynamical systems. It focuses on Boolean automata networks. In such networks, there are many ways to update the states of every element. When this is done deterministically, at each time step of a discretised time flow and according to a predefined order, we say that the network is updated according to block-sequential update schedule (blocks of elements are updated sequentially while, within each block, the elements are updated synchronously). Many studies, for the sake of simplicity and with some biologically motivated reasons, have concentrated on networks updated with one particular block-sequential update schedule (more often the synchronous/parallel update schedule or the sequential update schedules). The aim of this paper is to give an argument formally proven and inspired by biological considerations in favour of the fact that the choice of a particular update schedule does not matter so much in terms of the possible and likely dynamical behaviours that networks may display

Discrete time piecewise affine models of genetic regulatory networks

We introduce simple models of genetic regulatory networks and we proceed to the mathematical analysis of their dynamics. The models are discrete time dynamical systems generated by piecewise affine contracting mappings whose variables represent gene expression levels. When compared to other models of regulatory networks, these models have an additional parameter which is identified as quantifying interaction delays. In spite of their simplicity, their dynamics presents a rich variety of behaviours. This phenomenology is not limited to piecewise affine model but extends to smooth nonlinear discrete time models of regulatory networks. In a first step, our analysis concerns general properties of networks on arbitrary graphs (characterisation of the attractor, symbolic dynamics, Lyapunov stability, structural stability, symmetries, etc). In a second step, focus is made on simple circuits for which the attractor and its changes with parameters are described. In the negative circuit of 2 genes, a thorough study is presented which concern stable (quasi-)periodic oscillations governed by rotations on the unit circle -- with a rotation number depending continuously and monotonically on threshold parameters. These regular oscillations exist in negative circuits with arbitrary number of genes where they are most likely to be observed in genetic systems with non-negligible delay effects.Comment: 34 page

Boolean networks synchronism sensitivity and XOR circulant networks convergence time

In this paper are presented first results of a theoretical study on the role of non-monotone interactions in Boolean automata networks. We propose to analyse the contribution of non-monotony to the diversity and complexity in their dynamical behaviours according to two axes. The first one consists in supporting the idea that non-monotony has a peculiar influence on the sensitivity to synchronism of such networks. It leads us to the second axis that presents preliminary results and builds an understanding of the dynamical behaviours, in particular concerning convergence times, of specific non-monotone Boolean automata networks called XOR circulant networks.Comment: In Proceedings AUTOMATA&JAC 2012, arXiv:1208.249

Positive circuits and maximal number of fixed points in discrete dynamical systems

We consider the Cartesian product X of n finite intervals of integers and a map F from X to itself. As main result, we establish an upper bound on the number of fixed points for F which only depends on X and on the topology of the positive circuits of the interaction graph associated with F. The proof uses and strongly generalizes a theorem of Richard and Comet which corresponds to a discrete version of the Thomas' conjecture: if the interaction graph associated with F has no positive circuit, then F has at most one fixed point. The obtained upper bound on the number of fixed points also strongly generalizes the one established by Aracena et al for a particular class of Boolean networks.Comment: 13 page