5,215 research outputs found

    A pattern-based approach to a cell tracking ontology

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    Time-lapse microscopy has thoroughly transformed our understanding of biological motion and developmental dynamics from single cells to entire organisms. The increasing amount of cell tracking data demands the creation of tools to make extracted data searchable and interoperable between experiment and data types. In order to address that problem, the current paper reports on the progress in building the Cell Tracking Ontology (CTO): An ontology framework for describing, querying and integrating data from complementary experimental techniques in the domain of cell tracking experiments. CTO is based on a basic knowledge structure: the cellular genealogy serving as a backbone model to integrate specific biological ontologies into tracking data. As a first step we integrate the Phenotype and Trait Ontology (PATO) as one of the most relevant ontologies to annotate cell tracking experiments. The CTO requires both the integration of data on various levels of generality as well as the proper structuring of collected information. Therefore, in order to provide a sound foundation of the ontology, we have built on the rich body of work on top-level ontologies and established three generic ontology design patterns addressing three modeling challenges for properly representing cellular genealogies, i.e. representing entities existing in time, undergoing changes over time and their organization into more complex structures such as situations

    Ontology-based Classification and Analysis of non- emergency Smart-city Events

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    Several challenges are faced by citizens of urban centers while dealing with day-to-day events, and the absence of a centralised reporting mechanism makes event-reporting and redressal a daunting task. With the push on information technology to adapt to the needs of smart-cities and integrate urban civic services, the use of Open311 architecture presents an interesting solution. In this paper, we present a novel approach that uses an existing Open311 ontology to classify and report non-emergency city-events, as well as to guide the citizen to the points of redressal. The use of linked open data and the semantic model serves to provide contextual meaning and make vast amounts of content hyper-connected and easily-searchable. Such a one-size-fits-all model also ensures reusability and effective visualisation and analysis of data across several cities. By integrating urban services across various civic bodies, the proposed approach provides a single endpoint to the citizen, which is imperative for smooth functioning of smart cities

    Exploring manuscripts: sharing ancient wisdoms across the semantic web

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    Recent work in digital humanities has seen researchers in-creasingly producing online editions of texts and manuscripts, particularly in adoption of the TEI XML format for online publishing. The benefits of semantic web techniques are un-derexplored in such research, however, with a lack of sharing and communication of research information. The Sharing Ancient Wisdoms (SAWS) project applies linked data prac-tices to enhance and expand on what is possible with these digital text editions. Focussing on Greek and Arabic col-lections of ancient wise sayings, which are often related to each other, we use RDF to annotate and extract seman-tic information from the TEI documents as RDF triples. This allows researchers to explore the conceptual networks that arise from these interconnected sayings. The SAWS project advocates a semantic-web-based methodology, en-hancing rather than replacing current workflow processes, for digital humanities researchers to share their findings and collectively benefit from each other’s work

    Expressing OWL axioms by English sentences: dubious in theory, feasible in practice

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    With OWL (Web Ontology Language) established as a standard for encoding ontologies on the Semantic Web, interest has begun to focus on the task of verbalising OWL code in controlled English (or other natural language). Current approaches to this task assume that axioms in OWL can be mapped to sentences in English. We examine three potential problems with this approach (concerning logical sophistication, information structure, and size), and show that although these could in theory lead to insuperable difficulties, in practice they seldom arise, because ontology developers use OWL in ways that favour a transparent mapping. This result is evidenced by an analysis of patterns from a corpus of over 600,000 axioms in about 200 ontologies

    ImmPort, toward repurposing of open access immunological assay data for translational and clinical research

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    Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging studies for meta-analysis, or generating new hypotheses. To promote these goals, the ImmPort data repository was created for the broader research community to explore the wide spectrum of clinical and basic research data and associated findings. The ImmPort ecosystem consists of four components–Private Data, Shared Data, Data Analysis, and Resources—for data archiving, dissemination, analyses, and reuse. To date, more than 300 studies have been made freely available through the ImmPort Shared Data portal , which allows research data to be repurposed to accelerate the translation of new insights into discoveries
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