Segmentation d'images couleurs et multispectrales de la peau

La délimitation précise du contour des lésions pigmentées sur des images est une première étape importante pour le diagnostic assisté par ordinateur du mélanome. Cette thèse présente une nouvelle approche de la détection automatique du contour des lésions pigmentaires sur des images couleurs ou multispectrales de la peau. Nous présentons d'abord la notion de minimisation d'énergie par coupes de graphes en terme de Maxima A-Posteriori d'un champ de Markov. Après un rapide état de l'art, nous étudions l'influence des paramètres de l'algorithme sur les contours d'images couleurs. Dans ce cadre, nous proposons une fonction d'énergie basée sur des classifieurs performants (Machines à support de vecteurs et Forêts aléatoires) et sur un vecteur de caractéristiques calculé sur un voisinage local. Pour la segmentation de mélanomes, nous estimons une carte de concentration des chromophores de la peau, indices discriminants du mélanomes, à partir d'images couleurs ou multispectrales, et intégrons ces caractéristiques au vecteur. Enfin, nous détaillons le schéma global de la segmentation automatique de mélanomes, comportant une étape de sélection automatique des "graines" utiles à la coupure de graphes ainsi que la sélection des caractéristiques discriminantes. Cet outil est comparé favorablement aux méthodes classiques à base de coupure de graphes en terme de précision et de robustesse.Accurate border delineation of pigmented skin lesion (PSL) images is a vital first step in computer-aided diagnosis (CAD) of melanoma. This thesis presents a novel approach of automatic PSL border detection on color and multispectral skin images. We first introduce the concept of energy minimization by graph cuts in terms of maximum a posteriori estimation of a Markov random field (MAP-MRF framework). After a brief state of the art in interactive graph-cut based segmentation methods, we study the influence of parameters of the segmentation algorithm on color images. Under this framework, we propose an energy function based on efficient classifiers (support vector machines and random forests) and a feature vector calculated on a local neighborhood. For the segmentation of melanoma, we estimate the concentration maps of skin chromophores, discriminating indices of melanomas from color and multispectral images, and integrate these features in a vector. Finally, we detail an global framework of automatic segmentation of melanoma, which comprises two main stages: automatic selection of "seeds" useful for graph cuts and the selection of discriminating features. This tool is compared favorably to classic graph-cut based segmentation methods in terms of accuracy and robustness.SAVOIE-SCD - Bib.électronique (730659901) / SudocGRENOBLE1/INP-Bib.électronique (384210012) / SudocGRENOBLE2/3-Bib.électronique (384219901) / SudocSudocFranceF

Incorporating Colour Information for Computer-Aided Diagnosis of Melanoma from Dermoscopy Images: A Retrospective Survey and Critical Analysis

Cutaneous melanoma is the most life-threatening form of skin cancer. Although advanced melanoma is often considered as incurable, if detected and excised early, the prognosis is promising. Today, clinicians use computer vision in an increasing number of applications to aid early detection of melanoma through dermatological image analysis (dermoscopy images, in particular). Colour assessment is essential for the clinical diagnosis of skin cancers. Due to this diagnostic importance, many studies have either focused on or employed colour features as a constituent part of their skin lesion analysis systems. These studies range from using low-level colour features, such as simple statistical measures of colours occurring in the lesion, to availing themselves of high-level semantic features such as the presence of blue-white veil, globules, or colour variegation in the lesion. This paper provides a retrospective survey and critical analysis of contributions in this research direction

Photonics simulation and modelling of skin for design of spectrocutometer

fi=vertaisarvioitu|en=peerReviewed

Using Domain-Specific Information in Image Processing

With the increasing availability of high resolution imaging tools, even in our pockets (i.e. smartphones), everyday users can do far more than simply digitally capturing a family moment. The ease of new applications available in these portable forms, linked with users who have expert knowledge about the images and tasks, opens the door to new possibilities. With this in mind we propose two new approaches that utilize the user's knowledge for improved results. We apply these approaches to real life problems in medical and scientific image applications. In the first approach, we introduce a class of linear and nonlinear methods which we call Domain-Specific Grayscale (DSGS) methods. A DSGS method transforms a color image into an image analogous to a grayscale image, where user-specified information is used to optimize a specified image processing task and reduce the computational complexity. We introduce new methods based on projection into the space of single-coordinate images, and we adapt support vector machines by using their scores to create a DSGS image. We apply these methods to applications in dermatology, analyzing images of skin tests and skin lesions, and demonstrate their usefulness. In the second approach, we introduce a tool for improved image deblurring that safeguards against bias that can easily be introduced by a user favoring a particular result. This is particularly important in scientific and medical applications used for discovery or diagnosis. We provide real-time results of choices of regularization methods and parameter selection, and we check the statistical plausibility of the results, using three statistical diagnostics, allowing a user to see the results of the choices. Our work demonstrates the utility of domain-specific information, supplied by the user, in improving the results of image processing algorithms

Optical Methods in Sensing and Imaging for Medical and Biological Applications

The recent advances in optical sources and detectors have opened up new opportunities for sensing and imaging techniques which can be successfully used in biomedical and healthcare applications. This book, entitled ‘Optical Methods in Sensing and Imaging for Medical and Biological Applications’, focuses on various aspects of the research and development related to these areas. The book will be a valuable source of information presenting the recent advances in optical methods and novel techniques, as well as their applications in the fields of biomedicine and healthcare, to anyone interested in this subject

Under the skin : Monte Carlo radiation transfer modelling of photodynamic therapy

Photodynamic therapy (PDT) is a non-invasive treatment method used for treating superficial skin lesions such as non-melanoma skin cancer (NMSC). The combination of light, a photo- sensitive molecule and oxygen results in selective tissue destruction. Even though PDT has resulted in many successful treatment outcomes, the treatment parameters such as required light dose and preferred light source have not yet been optimised. Since monitoring of the treatment progress is limited to surface observations, it is difficult to observe what is happening under the surface of the skin. In this thesis, the development of complex numerical modelling techniques is considered with the aim of increasing the understanding of how PDT works within the living skin tis- sue. In particular, the potential of using daylight as an alternative therapeutic light source is explored. Daylight PDT is associated with lower experienced pain and has the potential of reducing pressure on the clinics as well as the number of treatment occasions. A Monte Carlo radiation transfer (MCRT) model was developed to track photon propagation during treatment. The first theoretical investigation of daylight PDT is presented where the results indicate a potential treatment depth of over 2 mm, which is sufficient for treating superficial skin cancer lesions. Additional models are developed, which consider the drug interaction and the diffusion of the drug. To include different patient characteristics and more detailed skin models, multi-layered tissue as well as complex three dimensional tumour tissues are included within the MCRT model framework. There is no such thing as a generic patient, making it difficult to generate standardised treatment protocols. The research performed in this thesis provides further insights into light interaction with skin tissue for different patient and treatment characteristics, which is a vital step towards achieving more individualised treatment regimes

Microscopy and Analysis

Microscopes represent tools of the utmost importance for a wide range of disciplines. Without them, it would have been impossible to stand where we stand today in terms of understanding the structure and functions of organelles and cells, tissue composition and metabolism, or the causes behind various pathologies and their progression. Our knowledge on basic and advanced materials is also intimately intertwined to the realm of microscopy, and progress in key fields of micro- and nanotechnologies critically depends on high-resolution imaging systems. This volume includes a series of chapters that address highly significant scientific subjects from diverse areas of microscopy and analysis. Authoritative voices in their fields present in this volume their work or review recent trends, concepts, and applications, in a manner that is accessible to a broad readership audience from both within and outside their specialist area