At the Biological Modeling and Simulation Frontier

We provide a rationale for and describe examples of synthetic modeling and simulation (M&S) of biological systems. We explain how synthetic methods are distinct from familiar inductive methods. Synthetic M&S is a means to better understand the mechanisms that generate normal and disease-related phenomena observed in research, and how compounds of interest interact with them to alter phenomena. An objective is to build better, working hypotheses of plausible mechanisms. A synthetic model is an extant hypothesis: execution produces an observable mechanism and phenomena. Mobile objects representing compounds carry information enabling components to distinguish between them and react accordingly when different compounds are studied simultaneously. We argue that the familiar inductive approaches contribute to the general inefficiencies being experienced by pharmaceutical R&D, and that use of synthetic approaches accelerates and improves R&D decision-making and thus the drug development process. A reason is that synthetic models encourage and facilitate abductive scientific reasoning, a primary means of knowledge creation and creative cognition. When synthetic models are executed, we observe different aspects of knowledge in action from different perspectives. These models can be tuned to reflect differences in experimental conditions and individuals, making translational research more concrete while moving us closer to personalized medicine

Inventing Philosophy

It is often suggested that Americans do not have a culture of their own, or a philosophy of their own. However, this charge assumes a European model of culture and philosophy, which Americans need not imitate. By contrast, this paper suggests an alternative, distinctly American model of philosophy. American philosophical practice is a kind of perpetual rebirth, a continuing innocence. It amounts to starting over, always, every time, and taking nothing for granted

Journal of the National Collegiate Honors Council, Vol. 17, No. 2 (Fall/Winter 2016) [complete issue]

In This Issue Forum Articles AP, Dual Enrollment, and the Survival of Honors Education •Annmarie Guzy Rethinking Honors Curriculum in Light of the AP/IB/Dual Enrollment Challenge: Innovation and Curricular Flexibility •David Coleman and Katie Patton Using Hybrid Courses to Enhance Honors Offerings in the Disciplines •Karen D. Youmans A Dual Perspective on AP, Dual Enrollment, and Honors •Heather C. Camp and Giovanna E. Walters Got AP? •Joan Digby AP: Not a Replacement for Challenging College Coursework •Margaret Walsh Research Essays The ICSS and the Development of Black Collegiate Honors Education in the U.S. •Traci L. M. Dula Reading Place, Reading Landscape: A Consideration of City as Text™ and Geography •Ellen Hostetter Demography of Honors: Comparing NCHC Members and Non-Members •Patricia J. Smith and Richard I. Scott The Effect of Honors Courses on Grade Point Averages •Art L. Spisak and Suzanne Carter Squires Honors Thesis Preparation: Evidence of the Benefits of Structured Curricula •Steven Engel A Digital Literacy Initiative in Honors: Perceptions of Students and Instructors about its Impact on Learning and Pedagogy • Jacob Alan English Helping the Me Generation Decenter: Service Learning with Refugees •LouAnne B. Hawkins and Leslie G. Kaplan The Honors College Experience Reconsidered: Exploring the Student Perspective •James H. Young, III, Lachel Story, Samantha Tarver, Ellen Weinauer, Julia Keeler, and Allison McQuirte

2017-2018 Undergraduate Bulletin

https://soundideas.pugetsound.edu/bulletins/1073/thumbnail.jp

2016-2017 Undergraduate Bulletin

https://soundideas.pugetsound.edu/bulletins/1071/thumbnail.jp