Digitalisation of Development and Supply Networks: Sequential and Platform-Driven Innovations

We draw from an eight-year dataset of 98 organisational entities involved in pre-competitive innovation networks across the UK pharmaceutical sector. These data map into three networks that are representative of: (i) a product development-led sequential pathway that begins with digitalised product development, followed by digitalisation of supply networks, (ii) a supply network-led sequential pathway that starts with digitalised supply networks, followed by digitalisation of product development, and (iii) a parallel — platform-driven — pathway that enables simultaneous digitalisation of development, production, and supply networks. We draw upon extant literature to assess these network structures along three dimensions — strategic intent, the integrative roles of nodes with high centrality, and innovation performance. We conduct within-case and cross-case analyses to postulate 10 research propositions that compare and contrast modalities for sequential and platform-based digitalisation involving collaborative innovation networks. With sequential development, our propositions are congruent with conventional pathways for mitigating innovation risks through modular moves. On the other hand, we posit that platform-based design rules, rather than modular moves, mitigate the risks for parallel development pathways, and lead to novel development and delivery mechanisms

Gradient Metaphoricity of the Preposition in: A Corpus-based Approach to Chinese Academic Writing in English

In Cognitive Linguistics, a conceptual metaphor is a systematic set of correspondences between two domains of experience (Kövecses 2020: 2). In order to have an extensive understanding of metaphors, metaphoricity (Müller and Tag 2010; Dunn 2011; Jensen and Cuffari 2014; Nacey and Jensen 2017) has been emphasized to address one of the properties of metaphors in language usage: gradience (Hanks 2006; Dunn 2011, 2014), which indicates that metaphorical expressions can be measured. Despite many noteworthy contributions, studies of metaphoricity are often accused of subjectivity (Müller 2008; Jensen and Cuffari 2014; Jensen 2017), this is why this study uses a big corpus as a database. Therefore, the main aim of this dissertation is to measure the gradient senses of the preposition in in an objective way, thus mapping the highly systematic semantic extension. Based on these gradient senses, the semantic and syntactic features of the preposition in produced by advanced Chinese English-major learners are investigated, combining quantitative and qualitative research methods. A quantitative analysis of the literal and other ten metaphorical senses of the preposition in is made at first. In accounting for the five factors influencing image schemata of each sense: “scale of Landmark”, “visibility”, “path”, “inclusion” and “boundary”, the formula of measuring the gradability of metaphorical degree is deduced: Metaphoricity=[[#Visibility] +[#Path] +[#Inclusion] +[#Boundary]]*[#Scale of Landmark]. The result is that the primary sense has the highest value:12, and all other extended senses have values down to zero. The more shared features with proto-scene, the higher the value of the metaphorical sense, and the less metaphorical the sense. EVENT and PERSON are the “least metaphoric” (value = 9-11); SITUATION, NUMBER, CONTENT and FIELD are “weak metaphoric” (value = 6-8); Also included are SEGMENTATION, TIME and MANNER (value = 3-5), and they are “strong metaphoric”; PURPOSE shares the least feature with proto-scene, and it has the lowest value, so it is “most metaphoric” (value = 0-2). Then, a corpus-based approach is employed, which offers a model for employing a corpus-based approach in Cognitive Linguistics. It compares two compiled sub-corpora: Chinese Master Academic Writing Corpus and Chinese Doctorate Academic Writing Corpus. The findings show that, on the semantic level, Chinese English-major students overuse in with a low level of metaphoricity, even advanced learners use the most metaphorical in rarely. In terms of syntactic behaviours, the most frequent nouns in [in+noun] construction are weakly metaphoric, whilst the nouns in the construction [in the noun of] are EVENT sense, which is least metaphorical. Moreover, action verbs tend to be used in the construction [verb+in] and [in doing sth.] in both master and doctorate groups. In the qualitative study, the divergent usages of the preposition in are explored. The preposition in is often substituted with other prepositions, such as on and at. The fundamental reason for the Chinese learners’ weakness is the negative transfer from their mother tongue (Wang 2001; Gong 2007; Zhang 2010). Although in and its Chinese equivalence zai...li (在...里) share the same proto-scene, there are discrepancies: the metaphorical senses of the preposition in are TIME, PURPOSE, NUMBER, CONTENT, FIELD, EVENT, SITUATION, SEGMENTATION, MANNER, PERSON, while those of zai...li (在...里) are only five: TIME, CONTENT, EVENT, SITUATION and PERSON. Thus the image schemata of each sense cannot be correspondingly mapped onto each other in different languages. This study also provides evidence for the universality and variation of spatial metaphors on the ground of cultural models. Philosophically, it supports the standpoint of Embodiment philosophy that abstract concepts are constructed on the basis of spatial metaphors that are grounded in the physical and cultural experience

UAV Model-based Flight Control with Artificial Neural Networks: A Survey

Model-Based Control (MBC) techniques have dominated flight controller designs for Unmanned Aerial Vehicles (UAVs). Despite their success, MBC-based designs rely heavily on the accuracy of the mathematical model of the real plant and they suffer from the explosion of complexity problem. These two challenges may be mitigated by Artificial Neural Networks (ANNs) that have been widely studied due to their unique features and advantages in system identification and controller design. Viewed from this perspective, this survey provides a comprehensive literature review on combined MBC-ANN techniques that are suitable for UAV flight control, i.e., low-level control. The objective is to pave the way and establish a foundation for efficient controller designs with performance guarantees. A reference template is used throughout the survey as a common basis for comparative studies to fairly determine capabilities and limitations of existing research. The end-result offers supported information for advantages, disadvantages and applicability of a family of relevant controllers to UAV prototypes

Measurement, optimisation and control of particle properties in pharmaceutical manufacturing processes

Previously held under moratorium from 2 June 2020 until 6 June 2022.The understanding and optimisation of particle properties connected to their structure and morphology is a common objective for particle engineering applications either to improve materialhandling in the manufacturing process or to influence Critical Quality Attributes (CQAs) linked to product performance. This work aims to demonstrate experimental means to support a rational development approach for pharmaceutical particulate systems with a specific focus on droplet drying platforms such as spray drying. Micro-X-ray tomography (micro-XRT) is widely applied in areas such as geo- and biomedical sciences to enable a three dimensional investigation of the specimens. Chapter 4 elaborates on practical aspects of micro-XRT for a quantitative analysis of pharmaceutical solid products with an emphasis on implemented image processing and analysis methodologies. Potential applications of micro-XRT in the pharmaceutical manufacturing process can range from the characterisation of single crystals to fully formulated oral dosage forms. Extracted quantitative information can be utilised to directly inform product design and production for process development or optimisation. The non-destructive nature of the micro-XRT analysis can be further employed to investigate structure-performance relationships which might provide valuable insights for modelling approaches. Chapter 5 further demonstrates the applicability of micro-XRT for the analysis of ibuprofen capsules as a multi-particulate system each with a population of approximately 300 pellets. The in-depth analysis of collected micro-XRT image data allowed the extraction of more than 200 features quantifying aspects of the pellets’ size, shape, porosity, surface and orientation. Employed feature selection and machine learning methods enabled the detection of broken pellets within a classification model. The classification model has an accuracy of more than 99.55% and a minimum precision of 86.20% validated with a test dataset of 886 pellets from three capsules. The combination of single droplet drying (SDD) experiments with a subsequent micro-XRT analysis was used for a quantitative investigation of the particle design space and is described in Chapter 6. The implemented platform was applied to investigate the solidification of formulated metformin hydrochloride particles using D-mannitol and hydroxypropyl methylcellulose within a selected, pragmatic particle design space. The results indicate a significant impact of hydroxypropyl methylcellulose reducing liquid evaporation rates and particle drying kinetics. The morphology and internal structure of the formulated particles after drying are dominated by a crystalline core of D-mannitol partially suppressed with increasing hydroxypropyl methylcellulose additions. The characterisation of formulated metformin hydrochloride particles with increasing polymer content demonstrated the importance of an early-stage quantitative assessment of formulation-related particle properties. A reliable and rational spray drying development approach needs to assess parameters of the compound system as well as of the process itself in order to define a well-controlled and robust operational design space. Chapter 7 presents strategies for process implementation to produce peptide-based formulations via spray drying demonstrated using s-glucagon as a model peptide. The process implementation was supported by an initial characterisation of the lab-scale spray dryer assessing a range of relevant independent process variables including drying temperature and feed rate. The platform response was captured with available and in-house developed Process Analytical Technology. A B-290 Mini-Spray Dryer was used to verify the development approach and to implement the pre-designed spray drying process. Information on the particle formation mechanism observed in SDD experiments were utilised to interpret the characteristics of the spray dried material.The understanding and optimisation of particle properties connected to their structure and morphology is a common objective for particle engineering applications either to improve materialhandling in the manufacturing process or to influence Critical Quality Attributes (CQAs) linked to product performance. This work aims to demonstrate experimental means to support a rational development approach for pharmaceutical particulate systems with a specific focus on droplet drying platforms such as spray drying. Micro-X-ray tomography (micro-XRT) is widely applied in areas such as geo- and biomedical sciences to enable a three dimensional investigation of the specimens. Chapter 4 elaborates on practical aspects of micro-XRT for a quantitative analysis of pharmaceutical solid products with an emphasis on implemented image processing and analysis methodologies. Potential applications of micro-XRT in the pharmaceutical manufacturing process can range from the characterisation of single crystals to fully formulated oral dosage forms. Extracted quantitative information can be utilised to directly inform product design and production for process development or optimisation. The non-destructive nature of the micro-XRT analysis can be further employed to investigate structure-performance relationships which might provide valuable insights for modelling approaches. Chapter 5 further demonstrates the applicability of micro-XRT for the analysis of ibuprofen capsules as a multi-particulate system each with a population of approximately 300 pellets. The in-depth analysis of collected micro-XRT image data allowed the extraction of more than 200 features quantifying aspects of the pellets’ size, shape, porosity, surface and orientation. Employed feature selection and machine learning methods enabled the detection of broken pellets within a classification model. The classification model has an accuracy of more than 99.55% and a minimum precision of 86.20% validated with a test dataset of 886 pellets from three capsules. The combination of single droplet drying (SDD) experiments with a subsequent micro-XRT analysis was used for a quantitative investigation of the particle design space and is described in Chapter 6. The implemented platform was applied to investigate the solidification of formulated metformin hydrochloride particles using D-mannitol and hydroxypropyl methylcellulose within a selected, pragmatic particle design space. The results indicate a significant impact of hydroxypropyl methylcellulose reducing liquid evaporation rates and particle drying kinetics. The morphology and internal structure of the formulated particles after drying are dominated by a crystalline core of D-mannitol partially suppressed with increasing hydroxypropyl methylcellulose additions. The characterisation of formulated metformin hydrochloride particles with increasing polymer content demonstrated the importance of an early-stage quantitative assessment of formulation-related particle properties. A reliable and rational spray drying development approach needs to assess parameters of the compound system as well as of the process itself in order to define a well-controlled and robust operational design space. Chapter 7 presents strategies for process implementation to produce peptide-based formulations via spray drying demonstrated using s-glucagon as a model peptide. The process implementation was supported by an initial characterisation of the lab-scale spray dryer assessing a range of relevant independent process variables including drying temperature and feed rate. The platform response was captured with available and in-house developed Process Analytical Technology. A B-290 Mini-Spray Dryer was used to verify the development approach and to implement the pre-designed spray drying process. Information on the particle formation mechanism observed in SDD experiments were utilised to interpret the characteristics of the spray dried material

Exploiting Modality-Specific Features For Multi-Modal Manipulation Detection And Grounding

AI-synthesized text and images have gained significant attention, particularly due to the widespread dissemination of multi-modal manipulations on the internet, which has resulted in numerous negative impacts on society. Existing methods for multi-modal manipulation detection and grounding primarily focus on fusing vision-language features to make predictions, while overlooking the importance of modality-specific features, leading to sub-optimal results. In this paper, we construct a simple and novel transformer-based framework for multi-modal manipulation detection and grounding tasks. Our framework simultaneously explores modality-specific features while preserving the capability for multi-modal alignment. To achieve this, we introduce visual/language pre-trained encoders and dual-branch cross-attention (DCA) to extract and fuse modality-unique features. Furthermore, we design decoupled fine-grained classifiers (DFC) to enhance modality-specific feature mining and mitigate modality competition. Moreover, we propose an implicit manipulation query (IMQ) that adaptively aggregates global contextual cues within each modality using learnable queries, thereby improving the discovery of forged details. Extensive experiments on the $\rm DGM^4$ dataset demonstrate the superior performance of our proposed model compared to state-of-the-art approaches.Comment: This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessibl

Error minimising gradients for improving cerebellar model articulation controller performance

In motion control applications where the desired trajectory velocity exceeds an actuator’s maximum velocity limitations, large position errors will occur between the desired and actual trajectory responses. In these situations standard control approaches cannot predict the output saturation of the actuator and thus the associated error summation cannot be minimised.An adaptive feedforward control solution such as the Cerebellar Model Articulation Controller (CMAC) is able to provide an inherent level of prediction for these situations, moving the system output in the direction of the excessive desired velocity before actuator saturation occurs. However the pre-empting level of a CMAC is not adaptive, and thus the optimal point in time to start moving the system output in the direction of the excessive desired velocity remains unsolved. While the CMAC can adaptively minimise an actuator’s position error, the minimisation of the summation of error over time created by the divergence of the desired and actual trajectory responses requires an additional adaptive level of control.This thesis presents an improved method of training CMACs to minimise the summation of error over time created when the desired trajectory velocity exceeds the actuator’s maximum velocity limitations. This improved method called the Error Minimising Gradient Controller (EMGC) is able to adaptively modify a CMAC’s training signal so that the CMAC will start to move the output of the system in the direction of the excessive desired velocity with an optimised pre-empting level.The EMGC was originally created to minimise the loss of linguistic information conveyed through an actuated series of concatenated hand sign gestures reproducing deafblind sign language. The EMGC concept however is able to be implemented on any system where the error summation associated with excessive desired velocities needs to be minimised, with the EMGC producing an improved output approximation over using a CMAC alone.In this thesis, the EMGC was tested and benchmarked against a feedforward / feedback combined controller using a CMAC and PID controller. The EMGC was tested on an air-muscle actuator for a variety of situations comprising of a position discontinuity in a continuous desired trajectory. Tested situations included various discontinuity magnitudes together with varying approach and departure gradient profiles.Testing demonstrated that the addition of an EMGC can reduce a situation’s error summation magnitude if the base CMAC controller has not already provided a prior enough pre-empting output in the direction of the situation. The addition of an EMGC to a CMAC produces an improved approximation of reproduced motion trajectories, not only minimising position error for a single sampling instance, but also over time for periodic signals

Recent Developments on Mobile Ad-Hoc Networks and Vehicular Ad-Hoc Networks

This book presents collective works published in the recent Special Issue (SI) entitled "Recent Developments on Mobile Ad-Hoc Networks and Vehicular Ad-Hoc Networks”. These works expose the readership to the latest solutions and techniques for MANETs and VANETs. They cover interesting topics such as power-aware optimization solutions for MANETs, data dissemination in VANETs, adaptive multi-hop broadcast schemes for VANETs, multi-metric routing protocols for VANETs, and incentive mechanisms to encourage the distribution of information in VANETs. The book demonstrates pioneering work in these fields, investigates novel solutions and methods, and discusses future trends in these field

A path planning control for a vessel dynamic positioning system based on robust adaptive fuzzy strategy

The thrusters and propulsion propellers systems, as well as the operating situations, are all well-known nonlinearities which are caused less accuracy of the dynamic positioning system (DPS) of vessels in the path planning control process. In this study, to enhance the robust performance of the DPS, we proposed a robust adaptive fuzzy control model to reduce the effect of uncertainty problems and disturbances on the DPS. Firstly, the adaptive fuzzy controller with adaptive law is designed to adjust the membership function of the fuzzy controller to minimize the error in path planning control of the vessel. Secondly, the H∞ performance of robust tracking is proved by the Lyapunov theory. Moreover, compared to the other controller, a simulation experiment comprising two case studies confirmed the efficiency of the approach. Finally, the results showed that the proposed controller reaches control quality, performance and stability

Program and Proceedings: The Nebraska Academy of Sciences 1880-2011

PROGRAM FRIDAY, APRIL 15, 2011 REGISTRATION FOR ACADEMY, Lobby of Lecture wing, Olin Hall Aeronautics and Space Science, Session A, Olin 249 Aeronautics and Space Science, Session B, Olin 224 Collegiate Academy, Biology Session A, Olin B Collegiate Academy, Chemistry and Physics, Session A, Olin 324 Chemistry and Physics, Section A, Chemistry, Olin A Biological and Medical Sciences, Session A, Olin 112 Biological and Medical Sciences, Session B, Smith Callen Conference Center Chemistry and Physics, Section B, Physics, Planetarium Junior Academy, Judges Check-In, Olin 219 Junior Academy, Senior High REGISTRATION, Olin Hall Lobby NWU Health and Sciences Graduate School Fair, Olin and Smith Curtiss Halls Junior Academy, Senior High Competition, Olin 124, Olin 131 Teaching of Science and Math, Olin 325 Aeronautics and Space Science, Poster Session, Olin 249 Applied Science and Technology, Olin 325 Aeronautics and Space Science, Poster Session, Olin 249 MAIBEN MEMORIAL LECTURE, OLIN B Dr. Erin Flynn, Nocturnal Manager, Omaha\u27s Henry Doorly Zoo LUNCH, PATIO ROOM, STORY STUDENT CENTER (pay and carry tray through cafeteria line, or pay at NAS registration desk) Aeronautics Group, Conestoga Room Anthropology, Olin 111 Biological and Medical Sciences, Session C, Olin 112 Biological and Medical Sciences, Session D, Smith Callen Conference Center Chemistry and Physics, Section A, Chemistry, Olin A Chemistry and Physics, Section B, Physics, Planetarium Collegiate Academy, Biology Session A, Olin B Collegiate Academy, Biology Session B, Olin 249 Collegiate Academy, Chemistry and Physics, Session B, Olin 324 Collegiate Academy, Chemistry and Physics, Session C, Olin 325 Earth Science, Olin 224 Junior Academy, Judges Check-In, Olin 219 Junior Academy, Junior High REGISTRATION, Olin Hall Lobby Junior Academy, Senior High Competition, (Final), Olin 110 Junior Academy, Junior High Competition, Olin 124, Olin 131 NJAS Board/Teacher Meeting, Olin 219 BUSINESS MEETING, OLIN B AWARDS RECEPTION for NJAS, Scholarships, Members, Spouses, and Guests First United Methodist Church, 2723 N 50th Street, Lincoln, N